Four Examples of Anti‐TSEN and Three of TSEN‐Positive Erythrocytes

Story, Jill R.; Lindsay, Gwenn; Rolih, Susan; Co, Asuncion; Rodberg, Karen; Harris, T.; Reid, Marion E.

doi:10.1046/j.1423-0410.2000.7930175.x

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…1,4 TSEN+ RBCs are usually found because of a discrepant S typing or by detection of an antibody to a low-prevalence antigen. 2,5,6 Extremely rare people have RBCs with a double dose of TSEN and have made an antibody to a high-prevalence MNS antigen. 7,8 We report a person who is heterozygous for GYP.JL and M k (the null allele in the MNS system).…”

mentioning

confidence: 99%

An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/M^k phenotype

Ratliff¹,

Veneman²,

Ward³

et al. 2007

Immunohematology

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The low-prevalence MNS blood group antigen TSEN is located at the junction of glycophorin A (GPA) to glycophorin B (GPB) in several hybrid glycophorin molecules. Extremely rare people have RBCs with a double dose of the TSEN antigen and have made an antibody to a high-prevalence MNS antigen. We report the first patient who is heterozygous for GYP.JL and M k . During prenatal tests, an alloantibody to a high-prevalence antigen was detected in the serum of a 21-year-old Hispanic woman. The antibody detected an antigen resistant to treatment by papain, trypsin, α-chymotrypsin, or DTT. The antibody was strongly reactive by the IAT with all RBCs tested except those having the M k M k , GP.Hil/GP.Hil, or GP.JL/GP.JL phenotypes. The patient's RBCs typed M+N-S+/-s-U+, En(a+/-), Hut-, Mi(a-), Mur-, Vw-, Wr(a-b-), and were TSEN+, MINY+. Reactivity with Glycine soja suggested that her RBCs had a decreased level of sialic acid. Immunoblotting showed the presence of monomer and dimer forms of a GP(A-B) hybrid and an absence of GPA and GPB. Sequencing of DNA and PCR-RFLP using the restriction enzyme RsaI confirmed the presence of a hybrid GYP(A-B). The patient's antibody was determined to be anti-En a FR. She is the first person reported with the GP.JL phenotype associated with a deletion of GYPA and GYPB in trans to GYP.JL.

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confidence: 99%

An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/M^k phenotype

Ratliff¹,

Veneman²,

Ward³

et al. 2007

Immunohematology

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“…One other example has been reported [371] and a few more examples are now known. Five examples of anti -TSEN have been reported, four of them by screening sera from 80 000 donors [301,311] .Only a single example anti -MINY is reported [302] .…”

Section: Anti-hil -Tsen and -Minymentioning

confidence: 99%

MNS Blood Group System

Daniels

2013

Human Blood Groups

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MNS Blood Group System

Reid

2012

The Blood Group Antigen FactsBook

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Four Examples of Anti‐TSEN and Three of TSEN‐Positive Erythrocytes

Cited by 5 publications

References 13 publications

An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/M^k phenotype

An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/M^k phenotype

MNS Blood Group System

MNS Blood Group System

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Four Examples of Anti‐TSEN and Three of TSEN‐Positive Erythrocytes

Cited by 5 publications

References 13 publications

An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/Mk phenotype

An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/Mk phenotype

MNS Blood Group System

MNS Blood Group System

Contact Info

Product

Resources

About

An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/M^k phenotype

An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/M^k phenotype