Four-Dimensional Measurement of the Displacement of Internal Fiducial Markers During 320-Multislice Computed Tomography Scanning of Thoracic Esophageal Cancer

Yamashita, Hideomi; Kida, Sigeo; Sakumi, A.; Haga, Akihiro; Ito, Shin; Onoe, Tsuyoshi; Okuma, Kae; Ino, Kenji; Akahane, Masaaki; Ohtomo, Kuni; Nakagawa, Keiichi

doi:10.1016/j.ijrobp.2010.03.045

Cited by 55 publications

(47 citation statements)

References 24 publications

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“…Other studies have reported that tumors in the distal esophagus had higher mobility compared with those in the middle and upper esophagus (9,10,15,17). The aim of the present study was to investigate the displacement differences between the superior and inferior ends of tumors located in the upper-middle thoracic esophagus in three directions.…”

Section: Discussionmentioning

confidence: 85%

“…Our results demonstrated that no significant differences in displacement were found between the upper and lower clips in the LR, SI and AP directions and, thus, differential ITV margins based on different parts of the tumor are not recommended. Previous studies have investigated the displacement of tumors in various parts of the esophagus with conflicting results (9,10,(15)(16)(17). For example, in a study by Lorchel et al (16), 8 patients that presented with esophageal malignancies underwent two conventional spiral CT scans during breath-hold procedure under spirometric control, and no association of tumor motion with anatomical location was observed.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the accuracy of the calculation of the marker centroids was limited, considering that the use of 3-mm CT slices affected the accuracy of the position of the markers by 1.0 cm. These errors may be reduced by acquiring CT images with a lower axial slice thickness or by volumetric acquisition (17,19).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, tumors located at the upper and middle thoracic esophagus were assessed, while it has been previously confirmed that tumors located in the distal esophagus are more mobile (9,10,(15)(16)(17). Therefore, a further exploratory study was performed by placing a third clip at the lower thoracic esophagus at 2 cm above the non-neoplastic GEJ to preliminarily determine whether displacement differences between the upper and lower ends of the tumor may also occur if the distal end of the tumor is located near the GEJ.…”

Section: Introductionmentioning

confidence: 92%

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Differences in displacement of the proximal and distal ends of mid-upper thoracic esophageal squamous cell carcinoma

Qiu

Wen

et al. 2016

Molecular and Clinical Oncology

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Abstract. In the present study, clips were used as markers to evaluate displacement differences between proximal and distal ends of esophageal tumors and to test whether their internal target volume (ITV) margins should be determined separately. A total of 23 patients with mid-upper thoracic esophageal squamous-cell carcinoma, a tumor length of ≤8 cm and an esophageal lumen suitable for endoscopic ultrasonography were recruited for the present study. Clips were implanted endoscopically at the proximal and distal ends of the esophageal tumor (upper and lower clips). In a further exploratory study on 16 of the patients, a third clip was placed at the distal esophagus 2 cm above the gastro-esophageal junction (GEJ) (cardiac clip). The clips were contoured for all 10 phases of the four-dimensional computed tomography and the maximum displacements of the clip centroids among different breathing phases in left-right (LR), superior-inferior (SI) and anterior-posterior (AP) directions were marked as x, y and z, respectively. The ITV margins that covered 95% of the LR, SI and AP motion were 2.89, 5.00 and 2.36 mm, respectively. Axial displacement (y) was greater than radial displacement (x, z; P<0.05). It was also revealed that LR(x), SI(y) and AP(z) displacement of cardiac clips was greater than that of upper or lower clips (P<0.05). Differences in the axial and radial displacement of the upper and lower clips indicated that axial and radial ITV margins should be determined separately. However, further study is required on patients in whom the distal tumor end is located in proximity to the GEJ.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

See 2 more Smart Citations

Differences in displacement of the proximal and distal ends of mid-upper thoracic esophageal squamous cell carcinoma

Qiu

Wen

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…It is likely that the respiratory-induced movement of the oesophagus influenced the analysis and affected comparability of the different imaging modalities [43,44]. Fast spiral CT and slow PET imaging are additionally different in displaying breathing motion during very different image acquisition times.…”

Section: Discussionmentioning

confidence: 99%