Four-day infusion of fluorouracil plus vinorelbine as salvage treatment of heavily pretreated metastatic breast cancer

Abstract

The combination of FU infusion and VNR i.v. is an effective salvage treatment for heavily pretreated metastatic breast cancer patients, and may represent a valid alternative when other cytotoxic regimens are not feasible.

Biweekly vinorelbine and tegafur/uracil in patients with metastatic breast cancer previously treated with anthracyclines and taxanes: GEICAM 2000–02 phase II study

“…In contrast, our results are quite similar to the results obtained in previous phase II and III trials in which vinorelbine was administered with a continuous infusion of 5-FU to patients with advanced breast cancer pretreated with anthracyclines and/or taxanes [31][32][33]. In these studies, overall response rates ranged from 38% to 61%, time to progression was between 5 and 15 months, and overall survival ranged from 16 to 22 months.…”

A Phase II Study of Combination Chemotherapy with Capecitabine and Intravenous Vinorelbine in Patients with Metastatic Breast Cancer Previously Treated with Anthracyclines and Taxanes: Efficacy and Tolerance

“…Similar results have also been reported in phase II and III trials in which vinorelbine was administered with continuous infusion of 5-FU to patients with advanced breast cancer pretreated with anthracyclines and/or taxanes 32,33 . In these studies, ORRs ranged from 38% to 63%, TTP was between 5.1 months and 15 months and OS ranged from 12.3 months to 22 months.…”

Use of heparin to lower the incidence of phlebitis induced by anti‐neoplastic agents used in ovarian cancer

“…The mean duration from the first administration of anti‐cancer agents to the diagnosis of phlebitis was 11 days (range 5–23 days). Some authors have showed that the duration of drug infusion is associated with the incidence of phlebitis 7,8 . The longer the duration of anti‐cancer drug infusion, the higher the incidence of phlebitis 8 .…”