Use of heparin to lower the incidence of phlebitis induced by anti‐neoplastic agents used in ovarian cancer

Ikeda, Shun‐ichi; Douchi, Tsutomu; Nagata, Yukihiro

doi:10.1111/j.1447-0756.2004.00225.x

Cited by 4 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Trials on topical heparin preparations have employed heparin application three times per day for a maximum of seven days or until the lesions heal for the management of SVT [ 16 ]. Although topical treatments are undoubtedly simpler to give, concurrent use of heparin infusion (5000 U) before and during the administration of antineoplastic drugs for a length of 12 hours reduces the occurrence of phlebitis in patients with ovarian cancer [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

A Multicentric, Prospective, Observational, Single-Arm Registry Study to Assess the Clinical Safety and Effectiveness of Thrombophob Ointment (Heparin Sodium + Benzyl Nicotinate) in Indian Patients With Thrombophlebitis

Somavarapu,

Kamala Kant Rakesh,

Roy

et al. 2024

Cureus

View full text Add to dashboard Cite

Purpose Thrombophlebitis is a frequent intravenous (IV) therapy consequence. Topical heparin for seven days is used as a treatment for thrombophlebitis. This study was performed to evaluate the clinical safety and effectiveness of the combination of heparin sodium & benzyl nicotinate (Thrombophob Ointment, manufactured by Zydus Healthcare Ltd., Ahmedabad, India) in thrombophlebitis patients in India. Methods A study carried out by 118 Indian doctors examined 2002 thrombophlebitis patients from 2016-2023, prescribing ointment containing heparin sodium and benzyl nicotinate. Patients were followed up on day three and day seven after starting the treatment, and safety and effectiveness were recorded, including adverse events. Result A total of 2002 patients were included in the study and males were predominant (58.15%). IV fluids (60.58%) were the leading cause of thrombophlebitis. The study found notable improvements in key markers of venous health over time. Compared to baseline, patients experienced significantly reduced severity of phlebitis, shorter venous lesion lengths, and lower pain and tenderness scores by both day 3 and day 7 (p<0.001 for all comparisons). Furthermore, these improvements continued between day 3 and day 7, indicating sustained positive effects (p<0.001 for all comparisons). After the application of the ointment, very few patients experienced adverse effects (0.25% on day three and 0.05% on day seven). Treatment effectiveness was excellent in 72% of patients, and treatment safety was excellent in 93% of patients. Conclusion The ointment containing heparin sodium and benzyl nicotinate was well tolerated and efficacious in the treatment of thrombophlebitis in Indian patients.

show abstract

Section: Discussionmentioning

confidence: 99%

A Multicentric, Prospective, Observational, Single-Arm Registry Study to Assess the Clinical Safety and Effectiveness of Thrombophob Ointment (Heparin Sodium + Benzyl Nicotinate) in Indian Patients With Thrombophlebitis

Somavarapu,

Kamala Kant Rakesh,

Roy

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Phlebitis is an inflammation of the vein caused by chemical, mechanical, or infectious irritation (Gorski, 2017; Higginson & Parry, 2011). Several pharmacological interventions (e.g., nonsteroidal antiinflammatory drugs (NSAIDs) (Berardi et al, 2003), heparin (Ikeda, Douchi, & Nagata, 2004), steroid ointment (Hamabe et al, 2017), and traditional medicines such as Sesame indicum (Bigdeli Shamloo et al, 2019), Nigella sativa (Behnamfar, Parsa Yekta, Mojab, & Kazem Naeini, 2019), and potato (Zhang, Jin, & Wang, 2018)) have been suggested to help reduce incidence of infusion phlebitis and CIP. However, the number of evidences is limited and it is yet unknown what are the most efficient methods.…”

Section: Discussionmentioning

confidence: 99%

Aloe vera and health outcomes: An umbrella review of systematic reviews and meta‐analyses

Sadoyu

Rungruang

Wattanavijitkul

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

This umbrella review aims to summarize the effects of Aloe vera on health outcomes and assess the strength of evidence. PubMed, Scopus, Embase, Cochrane database of systematic reviews, CINAHL, and AMED were searched from inception to October, 2019 for systematic reviews and meta‐analyses of clinical trials that investigated the effects of Aloe vera on health outcomes. Two independent reviewers extracted data, assessed the methodological quality, and rated the credibility of evidence according to established criteria. Ten articles reporting 71 unique outcomes of Aloe vera were included. Of these, 47 (67%) were nominally statistically significant based on random‐effects model (p ≤ .05). Only 3 outcomes were supported by highly suggestive evidence, whereas 42 outcomes were supported by weak evidence. The highly suggestive evidence supported benefits of Aloe vera in the prevention of second‐degree infusion phlebitis (RR: 0.18, 95% CI: 0.10–0.32, p‐value: 1.75 × 10−9) and chemotherapy‐induced phlebitis based on overall incidence (OR: 0.13, 95% CI: 0.08–0.20, p‐value: 9.68 × 10−20) and incidence of the second degree of severity (OR: 0.10, 95% CI: 0.07–0.14, p‐value: 3.41 × 10−35). However, the majority of the evidence were limited by small sample size and poor methodological quality. Therefore, despite the overall favorable effect of Aloe vera, more robust studies are needed.

show abstract

“…[8] Concomitant use of heparin infusion (5000 U) before and during the administration of antineoplastic agents for a duration of 12 h lowers the incidence of phlebitis in patients with ovarian cancers, but topical applications are definitely more easier to administer. [10]…”

Section: Discussionmentioning

confidence: 99%

A prospective randomized study to evaluate safety and efficacy of heparin topical solution (1000 IU/ml) compared to heparin topical gel (200 IU/g) in prevention of infusion-associated phlebitis

et al. 2018

View full text Add to dashboard Cite

OBJECTIVES:Thrombosis and thrombophlebitis of the superficial venous system are common in hospitalized patients. Efficacy and safety of topical quick penetrating solution (QPS) of heparin were compared to heparin sodium topical gel for the prevention of infusion-associated phlebitis.MATERIALS AND METHODS:Patients aged 18–65 years undergoing intravenous cannulation for at least 72 h were enrolled and randomized to receive 6–8 drops of topical solution of heparin (Group sodium topical solution [QPS]) or1 g of topical gel (Group GEL) over the cannulated vein every 8 hourly for a total of 10 doses. Enrolled patients were monitored every 8 ± 1 h for phlebitis using visual infusion phlebitis scale. The primary aim was to compare the proportion of patients with Grade 0, I, and II phlebitis at the end of 72 h of treatment period.RESULTS:Number of patients assessed for eligibility was 110; 26 excluded and 84 randomized. Analysis was done for 41 administered heparin QPS and 33 administered heparin gel as the rest were lost to follow-up. No phlebitis was reported in 32% of patients in QPS group and 9% in GEL group (P =0.0019). Proportion of patients with Grade I and Grade II phlebitis was 22.9% and 13.5% with QPS and 35.13% and 22.97% with gel, respectively, and the difference was statistically significant. Mean time to develop Grade I (Group QPS = 59.7 h; Group GEL = 58.46 h; P = 0.949) and Grade II (Group QPS = 62.4 h; Group GEL = 61.17 h; P = 0.732) phlebitis was comparable no adverse effects were reported in either group.CONCLUSION:Heparin QPS was more effective in he prevention of infusion-associated phlebitis with similar safety profile as heparin gel.

show abstract

Use of heparin to lower the incidence of phlebitis induced by anti‐neoplastic agents used in ovarian cancer

Abstract: Concurrent infusion of heparin and anti-neoplastic agents in ovarian cancer is a safe and effective method of preventing phlebitis induced by chemotherapy.

Cited by 4 publications

References 8 publications

A Multicentric, Prospective, Observational, Single-Arm Registry Study to Assess the Clinical Safety and Effectiveness of Thrombophob Ointment (Heparin Sodium + Benzyl Nicotinate) in Indian Patients With Thrombophlebitis

A Multicentric, Prospective, Observational, Single-Arm Registry Study to Assess the Clinical Safety and Effectiveness of Thrombophob Ointment (Heparin Sodium + Benzyl Nicotinate) in Indian Patients With Thrombophlebitis

Aloe vera and health outcomes: An umbrella review of systematic reviews and meta‐analyses

A prospective randomized study to evaluate safety and efficacy of heparin topical solution (1000 IU/ml) compared to heparin topical gel (200 IU/g) in prevention of infusion-associated phlebitis

Contact Info

Product

Resources

About