Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation

Yu, Shuaixia; Wang, Yan; Tang, Baijie; Liu, Xiang; Li, Song; Xu, Gang; Zhu, Hong; Sun, Huajun

doi:10.1186/s12957-022-02601-6

Cited by 5 publications

(5 citation statements)

References 55 publications

(56 reference statements)

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“…6A). Among them, KEGG analysis further revealed that Atp2a1, Cacna1s, Casq1, Hrc, Ryr1, Tnnc2, Mylk2, Mylk4, and Trdn, which probably participate in regulating intracellular calcium concentration through the calcium signaling pathway to modulate pain sensitivity [50][51][52], might mediate the effect of ErbB4 on inflammatory pain sensation (Fig. 6F).…”

Section: Discussionmentioning

confidence: 99%

Tyrosine kinase receptor ErbB4 in Advillin-positive neurons contributes to inflammatory pain hypersensitivity in mouse DRG

2023

Aging dis

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Inflammatory pain is a common type of pathological pain. Although the dorsal root ganglion (DRG) is key to pathogenesis of inflammatory pain, the underlying specific molecular and cellular mechanisms remain unclear. In this study, we used mouse models of acute or chronic inflammatory pain, induced by formalin or complete Freund' s adjuvant (CFA), respectively, to explore whether tyrosine kinase receptor ErbB4 participates in the pathogenesis of inflammatory pain. Firstly, we found that both the expression of Neuregulin 1 (Nrg1) and phosphorylation of ErbB4 receptor were upregulated in DRG after inflammatory pain, implying the activation of ErbB4 in DRG. Using ErbB4-mutant mice, we found reduced pain sensitivity of mice when ErbB4 gene expression was largely ablated; furthermore, ErbB4 deletion decreased the inflammatory pain hypersensitivity of either formalin-or CFA-induced mouse models. Moreover, the pain sensitivity was reduced in mice with specific deletion of ErbB4 on advillin-positive neurons within DRG. Importantly, pain hypersensitivity also decreased in Advillin-Cre;ErbB4 -/-cKO mice after formalin-or CFA-induced inflammatory pain. Finally, gene quantification differential expression analysis, using RNAseq technology in combination with GO and KEGG enrichment analysis, suggested that calcium signaling pathway possibly mediated the roles of ErbB4 on DRG sensory neurons in inflammatory pain models. Together, these results indicate that ErbB4 on advillin-positive sensory neurons enhances inflammatory pain sensitivity, providing new clues towards the pathogenic mechanisms of inflammatory pain.

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Section: Discussionmentioning

confidence: 99%

Tyrosine kinase receptor ErbB4 in Advillin-positive neurons contributes to inflammatory pain hypersensitivity in mouse DRG

2023

Aging dis

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“…The Food and Drug Administration has authorized one for subgroups of breast cancer patients[ 13 , 14 ]. Yu et al [ 15 ] investigated four calcium signaling pathway genes, including CACNA1S, RYR1, ATP2A1, and MYLK3, that were elevated in MAC at the RNA level and expressed more in MAC than in normal sweat glands and histologic mimics of MAC at the protein level. C-kit has been found in a subgroup of MAC patients, boosting the prospect of future use of imatinib mesylate.…”

Section: Discussionmentioning

confidence: 99%

Microcystic adnexal carcinoma misdiagnosed as a “recurrent epidermal cyst”: A case report

Yang¹,

Mou²,

Wang³

et al. 2022

WJCC

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BACKGROUND Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous adnexal neoplasm, often presenting as a flesh-colored and slow-growing indurated plaque or cystic nodule in the mid-facial region. Its characteristic indolent presentation usually leads to initial misdiagnosis, resulting in tumor mismanagement and added morbidity due to increased propensity for local invasion. CASE SUMMARY A 63-year-old Chinese male patient with a long-term history of excessive ultraviolet irradiation had received two surgeries for an “epidermal cyst” on his glabella and was presented to our hospital’s Dermatology Department for further diagnosis and therapy of the lesion on his glabella. One month ago, his two 7 mm × 7 mm subcutaneous nodules were diagnosed as "recurrent epidermal cysts", and he underwent local excision surgery. Additionally, he has post medical history of surgery for right clear cell renal carcinoma. According to his biopsy, the patient was diagnosed as MAC in our hospital, and a tumor remnant was found on his wound. He then underwent wide local excision to achieve negative margins and reconstruction of full-thickness flap transplantation for tissue coverage. He remained tumor-free after six months of follow-up. CONCLUSION This case highlights the importance of MAC’s possible pathogenic factor of excessive ultraviolet exposure, its differential diagnosis to avoid misdiagnosis and mismanagement to adverse prognosis, the patient’s particular medical history of clear cell renal carcinoma, the alert for any tumor recurrence in older patients, and his uncommon multiple nodules mess consisting of two 7 mm × 7 mm subcutaneous nodules, that will enrich the existing knowledge of MAC’s clinical features.

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“…Chan et al [52] found potential for therapeutic targeting of p53 or the JAK/STAT pathway in advanced microcystic adnexal carcinomas. Yu et al [53] addressed four genes of the calcium signaling pathway as upregulated in microcystic adnexal carcinomas at both RNA and protein levels suggesting that CACNA1S, ATP2A1, RYR1, and MYLK3 may be new diagnostic molecular markers and therapeutic targets in these rare neoplasms.…”

Section: Treatmentmentioning

confidence: 99%

Challenges in the diagnosis and treatment of the malignant adnexal neoplasms of the head and neck

Wierzbicka

Kraiński

Bartochowska

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of reviewThe current review is to present the current knowledge regarding epidemiology, diagnostics, and management of malignant adnexal neoplasms (MANs).Recent findingsImmunotherapy and gene-related therapies are still being developed as the methods of salvage treatment in advanced and disseminated cases: CACNA1S, ATP2A1, RYR1, and MYLK3, as well as p53 or the JAK/STAT pathways, may be therapeutic targets; the efficiency of talimogene laherparepvec and nivolumab is assessed.SummaryMANs are rare tumors, but due to the aging of population their incidence is increasing. Their clinical presentation is unspecific, which makes the diagnosis challenging. Histopathological assessment is difficult even for experienced pathologists. Mohs micrographic surgery or wide local excision are recommended to treat primary lesions. Adjuvant radiotherapy may be beneficial in case of insufficient or positive surgical margins, in nodal metastases, in selected types of MANs like sebaceous, trichilemmal, and pilomatrix carcinomas, and as the induction treatment in large tumors located in medically fragile or cosmetically important regions. The role of chemotherapy is not well defined; however, it is recommended in distant metastases. Immunotherapy can improve the prognosis in advanced stage of the disease.

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Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation

Cited by 5 publications

References 55 publications

Tyrosine kinase receptor ErbB4 in Advillin-positive neurons contributes to inflammatory pain hypersensitivity in mouse DRG

Tyrosine kinase receptor ErbB4 in Advillin-positive neurons contributes to inflammatory pain hypersensitivity in mouse DRG

Microcystic adnexal carcinoma misdiagnosed as a “recurrent epidermal cyst”: A case report

Challenges in the diagnosis and treatment of the malignant adnexal neoplasms of the head and neck

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