Fosinopril ameliorates exogenous cholesterol-induced incipient glomerular lesions in obese Zucker rats. Effects on eicosanoid secretion

Higueruelo, S; Vaquero, Manuel; C, Pastor; Galimany, R.; Romero, R.

doi:10.1093/ndt/13.9.2227

Cited by 7 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Angiotensin-converting enzyme inhibitors (ACEIs) have uniformly been shown to prevent the development of both proteinuria and GLS in diabetic rats and humans [9,10]. Calcium entry blockers (CCB) are being extensively used to treat systemic hypertension, and to prevent renal damage.…”

Section: Discussionmentioning

confidence: 99%

ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis

Blanco¹,

Bonet²,

López³

et al. 2005

Kidney International

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis

Blanco¹,

Bonet²,

López³

et al. 2005

Kidney International

View full text Add to dashboard Cite

show abstract

“…MPS (group 4, Table 2). Both of the dietary plant sterol formulations reduced serum cholesterol levels in the genetically obese Zucker rats used in studies measuring the effects of a cholesterol-rich diet (Higueruelo et al 1998;Vaskonen et al 1999Vaskonen et al , 2001. The cholesterol-lowering effect of the studied plant sterol preparations are in accordance with earlier studies on different animal models (Gould 1955;Bhattacharayya & LopeÂ z 1979) as well as in Explanations for groups 1±5 are given in Table 2. humans (Pollak 1952;Pollak & Kritchevsky 1981;Howard & Kritchevsky 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Other metabolic changes such as peripheral insulin resistance, hyperinsulinaemia and impaired glucose tolerance are observed, and hyperglycaemia also occurs (Kasiske et al 1985;McCaleb & Sredy 1992;Phillips et al 1996). Recent studies have shown that a cholesterol-rich diet significantly increases serum cholesterol in obese Zucker rats (Higueruelo et al 1998;Vaskonen et al 1999Vaskonen et al , 2001). In the present study, -sitosterol supplements were administered concurrently with a high cholesterol/high fat diet.…”

Section: Introductionmentioning

confidence: 99%

Effects of microcrystalline plant sterol suspension and a powdered plant sterol supplement on hypercholesterolemia in genetically obese Zucker rats

Summanen

Yrjönen

Christiansen

et al. 2003

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Because dietary fat appears to be an effective vehicle for dispensing plant sterols into the diet, a special plant-sterol-containing ingredient has recently been developed. This ingredient is a plant sterol suspension in oil in which the sterols are in microcrystalline form. The objective of the present study was to analyse the cholesterol-lowering effects and safety of two different plant sterol preparations, an orally administered microcrystalline plant sterol suspension (MPS) in rapeseed oil and a powdered plant sterol supplement, in obese Zucker rats. Dietary plant sterol supplements (0.5%, w/w) were given concurrently with a high cholesterol diet (HCD, 1% cholesterol and 18% fat, w/w). No significant changes in serum triglyceride, blood glucose, serum glutamate oxaloacetic transaminase and glutamic pyruvic transaminase values or body and liver weights were observed. The powdered plant sterol supplement lowered the serum cholesterol by 25% (P < 0.05) and the MPS diet by 35% (P < 0.001) compared with HCD by the end of the 12-week experiment. Interestingly, the plant sterol supplements also produced a marked reduction in serum ubiquinone levels, suggesting a possible effect on isoprene synthesis. Unlike the powdered plant sterol, both MPS and plain rapeseed oil decreased the serum baseline diene conjugation values, suggesting that they protect against oxidative stress-induced lipid peroxidation in rats. This lipid peroxidation diminishing effect is probably due to some antioxidative components in rapeseed oil. These findings indicate that an unesterified plant sterol, such as the microcrystalline suspension in oil, effectively prevents cholesterol absorption in obese Zucker rats.

show abstract

Potential role of angiotensin-converting enzyme inhibitors and statins on early podocyte damage in a model of type 2 diabetes mellitus, obesity, and mild hypertension

Blanco

Vaquero

Gómez-Guerrero

et al. 2005

American Journal of Hypertension

View full text Add to dashboard Cite

In the OZR, cholesterol was an important determinant of renal injury. Most notably, glomerulosclerosis in the OZR Is characterized by early podocyte damage and tubulointerstitial injury. In addition, our findings showed that quinapril primarily normalized podocyte morphology, whereas atorvastatin ameliorated renal lesions through the diminution of lipids and by its lipid-independent pleiotropic effect.

show abstract

Fosinopril ameliorates exogenous cholesterol-induced incipient glomerular lesions in obese Zucker rats. Effects on eicosanoid secretion

Abstract: In conclusion, exogenous cholesterol per se may contribute to nephropathy by increasing eicosanoid secretion, serum lipid profile, urinary protein excretion and the development of glomerular lesions. Fosinopril reduced all these parameters probably by its effects on Ang II.

Cited by 7 publications

References 1 publication

ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis

ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis

Effects of microcrystalline plant sterol suspension and a powdered plant sterol supplement on hypercholesterolemia in genetically obese Zucker rats

Potential role of angiotensin-converting enzyme inhibitors and statins on early podocyte damage in a model of type 2 diabetes mellitus, obesity, and mild hypertension

Contact Info

Product

Resources

About