Fortified hyperbranched PEGylated chitosan-based nano-in-micro composites for treatment of multiple bacterial infections

El-Salam, E. A. Abd; Shabaiek, Hager F.; Abdelaziz, Moustafa M.; Khalil, Islam A.; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.ijbiomac.2019.10.164

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…This trend was similar to the previous research results. [54] For Pal powder, there was an obvious endothermic peak at about 100 C, which was consistent with the mass loss showed by TGA pattern.…”

Section: Resultssupporting

confidence: 83%

Excellent effect of lubrication performance of chitosan/polyethylene glycol/palygorskite as water‐based lubricating additive on 304 stainless steel and polymer pairs

Liu

et al. 2022

Polymer Engineering & Sci

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In this work, Palygorskite (Pal) nanorods, chitosan (CS), and polyethylene glycol (PEG) are used to prepare new composite lubricants in order to improve the lubrication performance of water. The tribological experimental results showed that the composite lubricant composed with 1 wt% Pal, 10 wt% PEG and 2 wt% CS has excellent lubrication performance. The tribological data showed that the friction coefficient reached 0.021, and the composite lubricant lubrication performance was about 4 times higher than that of deionized water. The materials were characterized by scanning electron microscope (SEM), thermogravimetric analyses (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS), which revealed that the composite lubricant contained many oxygen-containing functional groups, and there was no chemical reaction between these functional groups. Instead, a lubricating film that can reduce friction and wear was formed through the hydrogen bond effect between functional groups. In this paper, a general and simple preparation method of new composite lubricant was proposed, which can be wildly used in many fields such as water-based lubrication.

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Section: Resultssupporting

confidence: 83%

Excellent effect of lubrication performance of chitosan/polyethylene glycol/palygorskite as water‐based lubricating additive on 304 stainless steel and polymer pairs

Liu

et al. 2022

Polymer Engineering & Sci

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“…BSA release was also sustained due to the PEGylated chitosan . Hyperbranched PEGylated chitosan-based nano and microcomposites can be a good choice against multiple bacterial infections …”

Section: Biomedical Applications Of Modified Chitosanmentioning

confidence: 97%

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Manna

Seth

Gupta

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past few decades, chitosan (CS) has gained the attention of researchers investigating newer biomaterial-based carriers for drugs in pharmaceutical and biomedical research. Combined with its nontoxic behavior, biodegradability, and biocompatibility, chitosan has found widespread applications in the fields of drug delivery, tissue engineering, and cosmetics. As a novel drug carrier, chitosan is regarded as one of the promising biomaterials in the pharmaceutical industry. The extensive use of this cationic biopolysaccharide in the delivery of therapeutic agents has brought a few limitations of chitosan into the limelight. Various chemical modifications of chitosan can minimize these limitations and improve the efficacy of chitosan as a drug carrier. The effectiveness of several chemically modified chitosan derivatives, including trimethyl chitosan, thiolated chitosan, PEGylated chitosan, and other chitosan derivatives, has been investigated by many researchers for the controlled and target specific delivery of therapeutics. The chemically modified chitosan derivatives exhibited greater importance in the current scenario on drug delivery due to their solubility in wide range of media along with their interaction with pharmaceutically active ingredients. Chitosan derivatives have also attracted attention in several biomedical fields, including wound healing, hyperthermia therapy, tissue engineering, and bioadhesives. The present review narrates the sources and common physicochemical properties of chitosan, including several important synthetic modifications to obtain chemically modified chitosans and their applications in targetspecific drug delivery, along with several biomedical applications.

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“…Animal use. The animal house provided us with female BALB/c mice that were between 5 and 6 weeks old and weighed 25 g each 63 . Animals were randomly divided into two test groups and two control group (n = 7 per group).…”

Section: Vibrating Sample Magnetometer (Vsm)mentioning

confidence: 99%

Targeted delivery of paclitaxel drug using polymer-coated magnetic nanoparticles for fibrosarcoma therapy: in vitro and in vivo studies

Al-Obaidy

Haider

Al-Musawi

et al. 2023

Sci Rep

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Fibrosarcoma is a rare type of cancer that affects cells known as fibroblasts that are malignant, locally recurring, and spreading tumor in fibrous tissue. In this work, an iron plate immersed in an aqueous solution of double added deionized water, supplemented with potassium permanganate solution (KMnO4) was carried out by the pulsed laser ablation in liquid method (PLAIL). Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized using different laser wavelengths (1064, 532, and 266 nm) at a fluence of 28 J/cm2 with 100 shots of the iron plate to control the concentration, shape and size of the prepared high-stability SPIONs. The drug nanocarrier was synthesized by coating SPION with paclitaxel (PTX)-loaded chitosan (Cs) and polyethylene glycol (PEG). This nanosystem was functionalized by receptors that target folate (FA). The physiochemical characteristics of SPION@Cs-PTX-PEG-FA nanoparticles were evaluated and confirmed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-Ray diffraction (XRD), atomic force microscopy (AFM), and dynamic light scattering (DLS) methods. Cell internalization, cytotoxicity assay (MTT), apoptosis induction, and gene expression of SPION@Cs-PTX-PEG-FA were estimated in fibrosarcoma cell lines, respectively. In vivo studies used BALB/c tumor-bearing mice. The results showed that SPION@Cs-PTX-PEG-FA exhibited suitable physical stability, spherical shape, desirable size, and charge. SPION@Cs-PTX-PEG-FA inhibited proliferation and induced apoptosis of cancer cells (P < 0.01). The results of the in vivo study showed that SPION@Cs-PTX-PEG-FA significantly decreased tumor size compared to free PTX and control samples (P < 0.05), leading to longer survival, significantly increased splenocyte proliferation and IFN-γ level, and significantly decreased the level of IL-4. All of these findings indicated the potential of SPION@Cs-PTX-PEG-FA as an antitumor therapeutic agent.

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Fortified hyperbranched PEGylated chitosan-based nano-in-micro composites for treatment of multiple bacterial infections

Cited by 9 publications

References 48 publications

Excellent effect of lubrication performance of chitosan/polyethylene glycol/palygorskite as water‐based lubricating additive on 304 stainless steel and polymer pairs

Excellent effect of lubrication performance of chitosan/polyethylene glycol/palygorskite as water‐based lubricating additive on 304 stainless steel and polymer pairs

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Targeted delivery of paclitaxel drug using polymer-coated magnetic nanoparticles for fibrosarcoma therapy: in vitro and in vivo studies

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