Formylation of porphyrin platinum complexes

Abstract

The formylation reaction of platinum complexes of β -unsubstituted porphyrins was studied. The interaction of deuteroporphyrin IX derivatives with the Vilsmeyer reagent led to the selective formylation of their macrocycles in the β position. The resulting formyl derivatives of the porphyrins are of interest for fluorescent immunoassay.

Selective Vilsmeier–Haack aryl-formylations of tetrathienylporphyrin and its Ni(II) complex

“…On the other hand, the Zn(II) and Mg(II) compounds demetalate and protonate very easily, leading to less reactive porphyrin derivatives [21,22]. Recently, Tan and co-workers reported a selective monoformylation of a meso-triphenyl-monothienylporphyrin, thus containing only one free a-position in the only thienyl moiety [23].…”