Formulations of Staphylococcus aureus bacteriophage in biodegradable beta-glucan and arabinogalactan-based matrices

Veverka, Miroslav; Dubaj, Tibor; Gallovič, Ján; Veverková, Eva; Šimon, Peter; Lokaj, J.; Jorı́k, Vladimı́r

doi:10.1016/j.jddst.2020.101909

Cited by 8 publications

(4 citation statements)

References 44 publications

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“…(P. vulgaris, P. mirabilis), Klebsiella spp. (K. pneumoniae, K. oxytoca), Pseudomonas aeruginosa and Escherichia coli Polyvinyl alcohol (PVA), aqueous solution of bacteriophages "Complex Pyobacteriophage" and succinic acid; Polyvinyl alcohol (PVA) and aqueous solution of bacteriophages "Complex Pyobacteriophage" and lidocaine; Polyvinyl alcohol (PVA) and aqueous solution of bacteriophages "Complex Pyobacteriophage" and succinic acid and lidocaine [103] Escherichia coli Polyvinyl alcohol (PVA) hydrogel and bacteriophage [112] Acinetobacter baumannii Sodium alginate, choline oleate and lytic bacteriophages [105] Escherichia coli Sodium alginate, gelatin, and hyaluronic acid for encapsulating acid fibroblast growth factor (aFGF) and bacteriophages [113] Pseudomonas aeruginosa Polycaprolactone (PCL) nanofibers (non-woven textile) and bacteriophages [110] Staphylococcus aureus Beta-glucan (BG), arabinogalactan, gums, and bacteriophages [114] Enterococcus faecalis Alginate-nanohydroxyapatite hydrogel and phages [115]…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Phage Delivery Strategies for Biocontrolling Human, Animal, and Plant Bacterial Infections: State of the Art

Vila,

Balcão,

Balcão

2024

Pharmaceutics

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This review aims at presenting the main strategies that are currently available for the delivery of bacteriophages to combat bacterial infections in humans, animals, and plants. It can be seen that the main routes for phage delivery are topical, oral, systemic, and airways for humans. In animals, the topical and oral routes are the most used. To combat infections in plant species, spraying the plant’s phyllosphere or drenching the soil are the most commonly used methods. In both phage therapy and biocontrol using phages, very promising results have been obtained so far. However, more experiments are needed to establish forms of treatment and phage doses, among other parameters. Furthermore, in general, there is a lack of specific standards for the use of phages to combat bacterial infections.

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Section: Staphylococcus Aureusmentioning

confidence: 99%

Phage Delivery Strategies for Biocontrolling Human, Animal, and Plant Bacterial Infections: State of the Art

Vila,

Balcão,

Balcão

2024

Pharmaceutics

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“…They ensure successful encapsulation, protection, and controlled release of quercetin for colon-targeted drug delivery [ 217 ]. Moreover, arabinogalactan-based nanoparticles are also suitable as carriers for various therapeutic agents, such as recombinant human thrombin [ 218 ].…”

Section: Plant-based Biopolymeric Nanoparticles Used For Healthcare A...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.

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“…A single type of phage can be incorporated into hydrogel matrices. 90 However, resistant bacterial variants may emerge as a side effect. Therefore, various strategies are employed, such as loading multiple phages in a cocktail or combining phages with antibiotics.…”

Section: Hydrogels Against Infectionsmentioning

confidence: 99%

Functional hydrogels for diabetic wound management

et al. 2021

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Diabetic wounds often have a slow healing process and become easily infected owing to hyperglycemia in wound beds. Once planktonic bacterial cells develop into biofilms, the diabetic wound becomes more resistant to treatment. Although it remains challenging to accelerate healing in a diabetic wound due to complex pathology, including bacterial infection, high reactive oxygen species, chronic inflammation, and impaired angiogenesis, the development of multifunctional hydrogels is a promising strategy. Multiple functions, including antibacterial, pro-angiogenesis, and overall pro-healing, are high priorities. Here, design strategies, mechanisms of action, performance, and application of functional hydrogels are systematically discussed. The unique properties of hydrogels, including bactericidal and wound healing promotive effects, are reviewed. Considering the clinical need, stimuli-responsive and multifunctional hydrogels that can accelerate diabetic wound healing are likely to form an important part of future diabetic wound management.

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Formulations of Staphylococcus aureus bacteriophage in biodegradable beta-glucan and arabinogalactan-based matrices

Cited by 8 publications

References 44 publications

Phage Delivery Strategies for Biocontrolling Human, Animal, and Plant Bacterial Infections: State of the Art

Phage Delivery Strategies for Biocontrolling Human, Animal, and Plant Bacterial Infections: State of the Art

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Functional hydrogels for diabetic wound management

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