Formulation optimization and evaluation of Cefdinir nanosuspension using 23 Factorial design

Abstract

Poor water solubility and slow dissolution rate are the prime issues for the majority of upcoming and existing biologically active compounds. Cefdinir is a poorly water-soluble drug and its bioavailability is very low from its crystalline form. The purpose of the present investigation was to increase the solubility and dissolution rate of Cefdinir by preparation of its nanosuspension by solvent evaporation technique. The prepared formulation of nanosuspension was evaluated for its particle size, total drug content, entrapment efficiency, saturation solubility and in vitro dissolution. The optimized formulation was spray dried to obtain nanoparticles. The prepared nanoparticles were then evaluated for their particle size, saturation solubility and in-vitro drug release and the results were compared with the pure drug. A 2 3 factorial design was employed to study the effect of independent variables, amount of PVPK-30 (X1), Poloxamer-188 (X2) and stirring rate (X3) on the dependent variables, particle size (nm,Y1) and in-vitro drug release (%, Y2). Validity of the developed mathematical equation was assayed by designing to check point. The results indicated the suitability of solvent evaporation method for Cefdinir with improved in vitro dissolution rate and thus perhaps enhance fast onset of action for the drug.

Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell

“…Nanoparticles have been applicable as significant technology to deliver drugs, including peptides and proteins, vaccines and more newly nucleotides. Production of nanoparticles by using Green synthesis technique using plants has become an attractive area of research [ 16 ]. It offers advantages over the chemical and physical methods as they are cheaper, eco friendly and easily scrabbled up for huge scale synthesis and also there is no need of high energy, temperature, and hazardous chemicals.…”

Enhancement of Solubility of Poorly Soluble Drug Lansoprazole

“…The FTIR spectra of lansoprazole showed the functional groups peaks as per reported peaks [1] and DSC thermogram of lansoprazole exhibited at 180.55 °C endothermic peak; this specifies the crystalline nature of lansoprazole and peak at 181.94 °C is exothermic, confirms the decomposition of lansoprazole [16]. The FTIR spectra and DSC thermogram represented in fig.…”

“…The FTIR spectra was scanned in the range of 4000-400 cm-1 [15]. For DSC thermogram scanning rate 10 °C/min was maintained to heat the sample from 30 °C to 350 °C [16]. For Lansoprazole also similar characterization was done.…”

Cefdinir Inclusion in Mesoporous Silica as Effective Dissolution Enhancer with Improved Physical Stability

“…Several approaches have been investigated to improve the dissolution rate and bioavailability of Cefdinir, including nanosuspensions [8,9], amorphization [10], cyclodextrin complexation [7,11], self-emulsification [12], and solid dispersions (SDs) [13][14][15][16][17].…”