Formulation optimization and characterization of transdermal film of curcumin by response surface methodology

Kriplani, Priyanka; Guarve, Kumar; Baghel, Uttam Singh

doi:10.1016/j.chmed.2020.12.001

Cited by 14 publications

(15 citation statements)

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“…Thus, DES can be employed for topical formulations for enhanced delivery by a non-invasive technique to deliver various poorly water-soluble bioactive molecules [106]. For transdermal delivery of curcumin, various drug delivery systems were employed [115][116][117][118]. These delivery systems were checked for drug permeation using Franz diffusion cell, utilizing animal skins (rat, pig) [114][115][116][117].…”

Section: Therapeutic Deep Eutectic Solvents (Thedes)mentioning

confidence: 99%

“…These delivery systems were checked for drug permeation using Franz diffusion cell, utilizing animal skins (rat, pig) [114][115][116][117]. The drug delivery systems were based on microemulsion, nanocrystals, and smart films [115][116][117][118][119]. The drug permeation was studied over periods of time ranging from minutes to hours [115][116][117][118][119].…”

Section: Therapeutic Deep Eutectic Solvents (Thedes)mentioning

confidence: 99%

“…The drug delivery systems were based on microemulsion, nanocrystals, and smart films [115][116][117][118][119]. The drug permeation was studied over periods of time ranging from minutes to hours [115][116][117][118][119]. The permeation enhancers or lipophilicities were also used for enhanced drug permeation.…”

Section: Therapeutic Deep Eutectic Solvents (Thedes)mentioning

confidence: 99%

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Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents

2022

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Recently, deep eutectic solvent (DES) or ionic liquid (IL) analogues have been considered as the newest green solvent, demonstrating the potential to replace harsh volatile organic solvents. DESs are mainly a combination of two compounds: hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD), which have the ability to interact through extensive hydrogen bonds. A thorough understanding of their physicochemical properties is essential, given their successful applications on an industrial scale. The appropriate blend of HBA to HBD can easily fine-tune DES properties for desired applications. In this context, we have reviewed the basic information related to DESs, the two most studied physicochemical properties (density and viscosity), and their performance as a solvent in (i) drug delivery and (ii) extraction of biomolecules. A broader approach of various factors affecting their performance has been considered, giving a detailed picture of the current status of DESs in research and development.

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Section: Therapeutic Deep Eutectic Solvents (Thedes)mentioning

confidence: 99%

Section: Therapeutic Deep Eutectic Solvents (Thedes)mentioning

confidence: 99%

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Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents

2022

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“…Compared with OFAT, DoE exerts the advantage of acquiring the maximum amount of experimental data with least experiment times, shortest experiment period, and lowest experiment cost. DoE has been successfully applied in different fields and industries, such as the food [4], energy [5], pharmaceutical [6], biology [7], environment [8], and engineering [9]. In recent years, the application of DoE for the chromatographic parameter optimization has developed vigorously.…”

Section: Introductionmentioning

confidence: 99%

Design of experiment techniques for the optimization of chromatographic analysis conditions: A review

et al. 2022

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Design of experiment (DoE) techniques have been widely used in the field of chromatographic parameters optimization as a valuable tool. A systematic literature review of the available DoE techniques applied to the development of a chromatographic analysis method is presented in this paper. First, the most common available designs and the implementation steps of DoE are comprehensively introduced. Then the studies in recent 10 years for the application of DoE techniques in various chromatographic techniques are discussed, such as capillary electrophoresis, liquid chromatography, gas chromatography, thin‐layer chromatography, and high‐speed countercurrent chromatography. Current problems and future outlooks are finally given to provide a certain inspiration of research in the application of DoE techniques to the different chromatographic techniques field. This review contributes to a better understanding of the DoE techniques for the efficient optimization of chromatographic analysis conditions, especially for the analysis of complex systems, such as multicomponent drugs and natural products.

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“…Chances of overdose or under dose can be reduced by removing the patch from the target site at any time that will end the treatment. [5][6][7] Based on literature survey, we have chosen quercetin, curcuminoids, and berberine HCl for herbal patch formulation since they have anti-inflammatory, anti-acne, antibacterial, and antioxidant characteristics. 5,[8][9][10][11] So the development of herbal patch formulation was the goal of the present work to enhance patient compliance and to control the drug release from patches to enhance bioavailability.…”

mentioning

confidence: 99%

Development, Optimization and Evaluation of Herbal Patch Formulation for Acne Treatment

Patel

Zaveri³

2022

Int J. Pharm. Investigation

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efficacy because of poor solubility, poor stability in highly acidic pH, first pass hepatic metabolism, risk of toxicity, and poor stability that lowers drug level below therapeutic concentration in blood, resulting in minimal or no therapeutic effect. 5 Among the many advantages of transdermal drug delivery are the avoidance of hepatic first pass metabolism and the maintenance of steady blood levels over an extended period of time, hence dosing frequency is reduced that decreases gastrointestinal irritation and improved the patient compliance for long term treatment. Chances of overdose or under dose can be reduced by removing the patch from the target site at any time that will end the treatment. [5][6][7] Based on literature survey, we have chosen quercetin, curcuminoids, and berberine HCl for herbal patch formulation since they have anti-inflammatory, anti-acne, antibacterial, and antioxidant characteristics. 5,[8][9][10][11] So the development of herbal patch formulation was the goal of the present work to enhance patient compliance and to control the drug release from patches to enhance bioavailability. For that preliminary screening was done for screening of polymers and plasticizers. The effect of ABSTRACT Background: More than 85% of young people around the world suffer from acne vulgaris, which is the most prevalent chronic inflammatory skin illness. The study's objective was to develop a herbal patch formulation contained quercetin, curcuminoids, and berberine HCl for the treatment of acne that utilizing ethyl cellulose and HPMC K4M as polymers and propylene glycol as a plasticizer. Materials and Methods: Drug excipient compatibility study was performed using FT-IR. Preliminary trial was done for screening of polymers and plasticizer concentrations. The combined influence of the two independent variables, namely the concentration of HPMC K4M and ethyl cellulose, on the dependent variables, tensile strength and cumulative % drug release at 24 hr, was examined using a 3 2 full factorial design. Patches were evaluated for physicochemical parameters. Results: Drug excipient compatibility study revealed that drug and excipients are compatible with each other. The optimized formulation (C0) showed tensile strength 2.56 kg/cm 2 , cumulative percentage drug release of quercetin, berberine HCl, and curcuminoids at 24 hr were 94.02%, 64.66%, and 94.21%, respectively. Tensile strength increased with an amount of HPMC K4M and Ethyl cellulose increases, the cumulative percentage of drug release decreased as HPMC K4M and ethyl cellulose concentrations were raised. Conclusion: Optimized herbal patch formulation had shown good physico-chemical and mechanical properties. The research shows that the developed formulation has the potential to be a useful replacement for the present medications in the market.

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Formulation optimization and characterization of transdermal film of curcumin by response surface methodology

Cited by 14 publications

References 45 publications

Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents

Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents

Design of experiment techniques for the optimization of chromatographic analysis conditions: A review

Development, Optimization and Evaluation of Herbal Patch Formulation for Acne Treatment

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