Formulation of Thermosensitive Hydrogel Containing Cyclodextrin for Controlled Drug Delivery of Camptothecin

Kushwaha, Swatantra Kumar Singh; Kumar, Awani; Singh, Surjit

doi:10.4314/tjpr.v13i7.1

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…In a study conducted by Kushwaha et al , camptothecin (CPT) was incorporated in a chitosan polymer matrix that had glycerol-2-phosphate (β-GP) added to the base structure. In addition, cyclodextrin was added as a cosolvent in order to increase solubility and facilitated the delivery of CPT by complexing with the drug using guest-host interactions [41]. By creating a complex, a chitosan polymer could remain a liquid at cool to room temperature and form a gel at 37 °C, remain stable at a physiological pH, and sufficiently hold the CPT-cyclodextrin payload, allowing for a slow release of the drug locally at the injection site.…”

Section: Preparation Of Hydrogels Carrying Hydrophobic Drugsmentioning

confidence: 99%

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Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

et al. 2015

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Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery. Much effort has been made to incorporate hydrophilic molecules in hydrogels in the field of drug delivery, while loading of hydrophobic drugs has not been vastly studied. However, in recent years, research has also been conducted on incorporating hydrophobic molecules within hydrogel matrices for achieving a steady release of drugs to treat various ailments. Here, we summarize the types of hydrogels used as drug delivery vehicles, various methods to incorporate hydrophobic molecules in hydrogel matrices, and the potential therapeutic applications of hydrogels in cancer.

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Section: Preparation Of Hydrogels Carrying Hydrophobic Drugsmentioning

confidence: 99%

“…Once the base vehicle was made, β-cyclodextrin was slowly added at room temperature to the chitosan β-GP solution. Once that solution was homogenized, CPT was added to the solution [41].…”

Section: Preparation Of Hydrogels Carrying Hydrophobic Drugsmentioning

confidence: 99%

Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

et al. 2015

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“…Cs-GP system has a great potential as scaffold material in tissue engineering and regenerative medicine due to its good biocompatibility, minimal immune reaction, high antibacterial nature, good adhesion to cells and the possibility to be moulded in various geometries [18][19][20][21][22][23][24][25][26]. For similar reasons, the other key pharmaceutical application of this material is a smart-controlled release system [4,18,20,[27][28][29][30][31][32][33][34][35][36][37][38], because the hydrogel is able to keep the drug level within the therapeutic window during extended periods of time, thus avoiding frequent low doses and undesirable secondary effects in patients. Important and interesting patents of biomedical applications of this system have been revised recently [39].…”

Section: Applicationsmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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“…Accordingly, the injectable biodegradable targeted drug delivery systems have been investigated by research scientists [ 9 , 10 ]. Different chemotherapeutic agents, including paclitaxel [ 11 ] camptothecin [ 12 ], doxorubicin [ 13 ], and methotrexate [ 14 ] have been prepared in biodegradable polymeric microspheres, hydrogels, surgical pastes, and implants to reduce their cytotoxicity and adverse effects. Thermosensitive hydrogels have a critical solution temperature at which they undergo a transition from a solution phase to a gel phase [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer

et al. 2022

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The treatment of breast cancer requires long chemotherapy management, which is accompanied by severe side effects. Localized delivery of anticancer drugs helps to increase the drug concentration at the site of action and overcome such a problem. In the present study, chitosan hydrogel was prepared for local delivery of 5-Fluorouracil. The in vitro release behavior was investigated and the anticancer activity was evaluated against MCF-7 cells using MTT assay. The in vivo studies were investigated via intra-tumoral injection of a 5-FU loaded hydrogel into breast cancer of female rats. The results indicated that the modified hydrogel has excellent physicochemical properties with a sustained in vitro release profile matching a zero-order kinetic for one month. In addition, the hydrogel showed superior inhibition of cell viability compared with the untreated control group. Moreover, the in vivo studies resulted in antitumor activity with minor side effects. The tumor volume and level of tumor markers in blood were inhibited significantly by applying the hydrogel compared with the untreated control group. In conclusion, the designed injectable hydrogels are potential drug delivery systems for the treatment of breast cancer with a controlled drug release profile, which could be suitable for decreasing the side effects of chemotherapy agents.

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Formulation of Thermosensitive Hydrogel Containing Cyclodextrin for Controlled Drug Delivery of Camptothecin

Cited by 7 publications

References 12 publications

Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

Chitosan-Based Thermosensitive Materials

Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer

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