2014
DOI: 10.1016/j.ijpharm.2014.08.008
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Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants

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Cited by 64 publications
(28 citation statements)
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“…The decrease in particle size is connected with a tremendous increase in surface area. It has been reported that SLN stabilized with surfactant mixtures and SLNs prepared with the combination of surfactants generally tend to have smaller particle size and higher storage stability by preventing particle agglomeration [43][44][45] . In this study, lipid to Flutamide ratio of 20 with 3% Precirol ATO-5 Õ (the final volume of formulation was 50 mL, thus the weight of lipid was 1.5 g), 0.6% Span Õ 80 and 5% Poloxamer Õ 407 at stirring rate of 20 000 rpm and 80 C resulted in the formation of SLNs with particle size of 192 nm.…”
Section: Resultsmentioning
confidence: 99%
“…The decrease in particle size is connected with a tremendous increase in surface area. It has been reported that SLN stabilized with surfactant mixtures and SLNs prepared with the combination of surfactants generally tend to have smaller particle size and higher storage stability by preventing particle agglomeration [43][44][45] . In this study, lipid to Flutamide ratio of 20 with 3% Precirol ATO-5 Õ (the final volume of formulation was 50 mL, thus the weight of lipid was 1.5 g), 0.6% Span Õ 80 and 5% Poloxamer Õ 407 at stirring rate of 20 000 rpm and 80 C resulted in the formation of SLNs with particle size of 192 nm.…”
Section: Resultsmentioning
confidence: 99%
“…The high zeta potential in CLN is considered to be due to the interaction between the hydrophilic parts of the surfactant and the water molecules during the process of nanoemulsion formulation to form potentially negative charges. These negative charges can be absorbed to the emulsifier layer of oil/water interface and electric double layer similar to that of ionic form (21,22).…”
Section: Discussionmentioning
confidence: 99%
“…The length of the alkyl chain is one of the factors which have an important influence on the surfactant properties such as: solubility in water, critical micellar concentration or hydrophilic-lipophilic balance (Geetha and Tyagi 2012;Keck et al 2014 A c c e p t e d M a n u s c r i p t 3 of APG on bacterial cells and biodegradation processes can also be determined by molecular structure of these surfactants. The aim of this study was to investigate changes in cell surface properties of Pseudomonas fluorescens ATCC 14700 in the presence of three alkyl polyglucosides of different alkyl chain length: Glucopon 215 CS UP, Glucopon 600 CS UP and Glucopon 650 EC.…”
Section: Introductionmentioning
confidence: 99%