Formulation of roselle extract water-in-oil nanoemulsion for controlled pulmonary delivery

Shekh, Adil Omer Baba; Wahab, Roswanira Abdul; Yahya, Nur Azzanizawaty

doi:10.1080/01932691.2022.2046044

Cited by 7 publications

(5 citation statements)

References 71 publications

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“…Average DS of the prepared NEs ranged from 251 ± 16 nm to 385 ± 20 nm, while the PDI ranged from 0.38 ± 0.1 to 0.45 ± 0.1 and ZP values ranged from -20 ± 3.6 mv to -70 ± 10.4 mv as showed in table 2. The droplet size appeared to be high in all formulations this may be due to higher solubility of PVS in oleic acid which increases PVS amount in the oil phase and thus increased the size of the droplet similar nding was previously reported [51,52]. Also, the angular structure of oleic acid could cause larger particles [53].…”

Section: 42-analysis Of Ds Pdi and Zpsupporting

confidence: 70%

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Pharmacodynamic studies of Pravastatin Sodium Nano emulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia.

Ibrahim

Dahan

Girgis

2023

Preprint

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Pravastatin sodium (PVS) is a hypolipidemic drug with poor oral bioavailability as a result of the first pass effect. This study aims to formulate and evaluate transdermal patch containing PVS loaded nanoemulsions (PVS-NEs) in order to increase PVS's hypolipidemic and hepatoprotective activities. PVS-NEs were prepared using the aqueous titration method. Oleic acid was chosen as an oil phase, span 80 and tween 80 were used as surfactant and cosurfactant respectively. Droplet size (DS), polydispersity index (PDI), zeta potential (ZP), clarity, Fourier-infrared spectroscopy (FT-IR) and thermodynamic stability of NEs were all characterized. PVS-NEs (NE2) with 50% oil phase, 40% SC mix 2:1 and 10% water was selected as an optimum formula based on the results of DS (251 ± 16), PDI (0.4 ± 0.16), and ZP (-70 ±10.4) to be incorporated into transdermal patch. PVS-NE2 loaded transdermal patches (PVS-NE2-TDPs) F1 were prepared by solvent evaporation method. F1 patch with HPMC E15 and PVP K30 in a ratio of 3:1 represented satisfactory patch properties with good drug-excipients compatibility thus, it was selected as an optimum patch formula. The optimized formula (F1) was prepared using hydroxypropyl methylcellulose E15 (HPMC, 15MPa.s), Polyvinylpyrrolidone (PVP) K30, polyethylene glycol 400 (PEG) and dimethyl sulfoxide (DMSO). F1 patch was characterized for thickness, moisture content, weight variation and drug- excipients incompatibility. F1 patch was subjected to ex vivo skin permeation and finally pharmacodynamic studies. Ex vivo permeation studies of F1 revealed that, the cumulative amount of PVS permeated across rat skin was (271.66 ± 19 µg/cm2) in 72h. Pharmacodynamic studies demonstrated that, F1 patch was more effective in treating hyperlipidemia than PVS-TDP (control patch) based on both blood analysis and histopathological examination.

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Section: 42-analysis Of Ds Pdi and Zpsupporting

confidence: 70%

“…The decrease in DS may be due to the nature of PVS that must be stored at lower temperature [56] and the oil droplets have been fully solubilized in tween 80 micelles for extended period [51,57,58]. This indicated that, lower temperature had better effect on NE2 stability [20,52].…”

Section: 5-stability Studies Of Ne2mentioning

confidence: 99%

Pharmacodynamic studies of Pravastatin Sodium Nano emulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia.

Ibrahim

Dahan

Girgis

2023

Preprint

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“…The anthocyanin release rate was relatively slow, demonstrating its applicability as a nanocarrier for pulmonary delivery. 114 Pangeni et al 115 formulated W/O/W multiphase NEs for the simultaneous administration of Pemetrexed (PTX) and QT. This formulation had synergistic anticancer effects and improved oral absorption, as it increased the PTX's permeation through the intestinal membrane and also enhanced the solubility of QT.…”

Section: Flavonoids-loaded Nanoemulsion In Cancer Therapymentioning

confidence: 99%

“…This study created a stable roselle extract NE without them. The anthocyanin release rate was relatively slow, demonstrating its applicability as a nanocarrier for pulmonary delivery …”

Section: Polyphenols-loaded Nanoemulsion In Cancer Therapymentioning

confidence: 99%

Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy

Tomar,

Das,

Balaga

et al. 2024

ACS Appl. Bio Mater.

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Cancer is one of the major causes of death worldwide, even the second foremost cause related to non-communicable diseases. Cancer cells typically possess several cellular and biological processes including, persistence, propagation, differentiation, cellular death, and expression of cellular-type specific functions. The molecular picture of carcinogenesis and progression is unwinding, and it appears to be a tangled combination of processes occurring within and between cancer cells and their surrounding tissue matrix. Polyphenols are plant secondary metabolites abundant in fruits, vegetables, cereals, and other natural plant sources. Natural polyphenols have implicated potential anticancer activity by various mechanisms involved in their antitumor action, including modulation of signaling pathways majorly related to cellular proliferation, differentiation, relocation, angiogenesis, metastatic processes, and cell death. The applications of polyphenols have been limited due to the hydrophobic nature and lower oral bioavailability that could be possibly overcome through encapsulating them into nanocarrier-mediated delivery systems, leading to improved anticancer activity. Nanoemulsions (NEs) possess diverse feasible properties, including greater surface area, modifiable surficial charge, higher half-life, site-specific targeting, and formulation imaging capability necessary to create a practical therapeutic impact, and have drawn increased attention in cancer therapy research. This review has summarized and discussed the basic concepts, classification, delivery approaches, and anticancer mechanism of various polyphenols and polyphenols-encapsulated nanoemulsions with improved cancer therapy.

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“…Emulsion-based systems are intended to overcome the low stability and bioavailability of anthocyanins. Among the most used systems are nanoemulsions and microemulsions that have been studied in vivo and in vitro as anthocyanin delivery systems [ 51 , 52 , 53 , 54 ].…”

Section: Anthocyanin-loaded Polymers: Preparation and Characterizatio...mentioning

confidence: 99%

Anthocyanin-Loaded Polymers as Promising Nature-Based, Responsive, and Bioactive Materials

Rosales-Murillo,

Sánchez-Bodón,

Hernández Olmos

et al. 2024

Polymers

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Anthocyanins are a specific group of molecules found in nature that have recently received increasing attention due to their interesting biological and colorimetric properties that have been successfully applied in several fields such as food preservation and biomedicine. Consequently, reviews devoted to a general overview of these flavonoids have proliferated in recent years. Meanwhile, the incorporation of anthocyanins into polymeric systems has become an interesting strategy to widen the applicability of these molecules and develop new smart and functional polymers in the above cited areas. However, anthocyanin-based polymers have been scarcely reviewed in the literature. Accordingly, this review aims to be a systematic summary of the most recent approaches for the incorporation of anthocyanins into macro-, micro-, or nanostructured polymers. Moreover, this work describes the fundamentals of the applicability of smart anthocyanin-based polymers and offers an updated review of their most interesting applications as sensors, biological regulators, and active materials.

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Formulation of roselle extract water-in-oil nanoemulsion for controlled pulmonary delivery

Cited by 7 publications

References 71 publications

Pharmacodynamic studies of Pravastatin Sodium Nano emulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia.

Pharmacodynamic studies of Pravastatin Sodium Nano emulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia.

Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy

Anthocyanin-Loaded Polymers as Promising Nature-Based, Responsive, and Bioactive Materials

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