Formulation of olanzapine nanosuspension based orally disintegrating tablets (ODT); comparative evaluation of lyophilization and electrospraying process as solidification techniques

Anup, Neelima; Thakkar, Shreya; Misra, Manju

doi:10.1016/j.apt.2018.05.003

Cited by 19 publications

(6 citation statements)

References 35 publications

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“…It is one of the most appropriate 2 nd generation atypical antipsychotic drug approved by US FDA as first line therapy for the treatment of psychotic disorders schizophrenia, anxiety, depression, and acute mania with bipolar disorder [31][32][33][34]. OLP binds and antagonizes many receptors (serotonin, dopamine, histamine, and alpha-1 adrenergic receptors) [35,36]. Even though olanzapine (OLP) is a poorly soluble drug (0.0942 mg/mL) which is an impediment to the schizophrenia treatment and leads to poor absorption and unreliable pharmacokinetic profile [37,38], for this purpose, in the current study, we developed the nanogel drug delivery system to improve the solubility and bioavailability profile of olanzapine.…”

Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement

Minhas

Khan

Sarfraz

et al. 2022

BioMed Research International

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Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately dosage increase. Current study is aimed at developing a polyvinylpyrrolidone- (PVP-K30-) based nanogel delivery system for solubility enhancement of poorly soluble drug olanzapine (OLP), as solubilization enhancement is the most noteworthy application of nanosystems. Crosslinking polymerization with subsequent condensation technique was used for the synthesis of nanogels, a highly responsive polymeric networks in drug’s solubility. Developed nanogels were characterized by percent entrapment efficiency, sol-gel, percent swelling, percent drug loaded content (%DLC), percent porosity, stability, solubility, in vitro dissolution studies, FTIR, XRD, and SEM analysis. Furthermore, cytotoxicity study was conducted on rabbits to check the biocompatibility of the system. Particle size of nanogels was found with 178.99 ± 15.32 nm , and in vitro dissolution study exhibited that drug release properties were considerably enhanced as compared to the marketed formulation OLANZIA. The solubility studies indicated that solubility of OLP was noticeably improved up to 36.7-fold in phosphate buffer of pH 6.8. In vivo cytotoxicity study indicated that prepared PVP-K30-based formulation was biocompatible. On the basis of results obtained, the developed PVP-K30-co-poly (AMPS) nanogel delivery system is expected to be safe, effective, and cost-effective for solubility improvement of poorly soluble drugs.

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Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement

Minhas

Khan

Sarfraz

et al. 2022

BioMed Research International

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“…The optimized PVA-mannitol based tablets exhibited disintegration time (∼14 s), friability (∼0.59), and 90% drug release time (∼8.9 min). Anup et al 83 developed electrosprayed and lyophilized olanzapine nanosuspensions for orally disintegrating tablet evaluation. The Electrospray method confirms hollow and porous particles with increased surface area and pore radius compared to the physical mixture.…”

Section: Nanoparticle-based Tablets a Tablet Incorporating Gold Nanop...mentioning

confidence: 99%

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of integrating nanomedicine within a tablet formulation, which facilitates the controlled release of drugs, biomolecules, and agent(s) from the formulation to achieve a better therapeutic response. Finally, an attempt was made to explore current trends in nanomedicine technology such as bacteriophage, probiotic, and oligonucleotide tabletized nanomedicine and the combination of nanomedicine with imaging agents, i.e., nanotheranostics.

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“…Drug nanosuspensions can be further converted to not only tablets (Mori et al., 2016; Anup et al., 2018), capsules (Bonhoeffer et al., 2018), creams (Lai et al., 2015), injectables (Lu et al., 2016; Yang et al., 2017; Sigfridsson et al., 2019) or other traditional formulations (Pailla et al., 2019), but it can be also loaded in carrier such as human erythrocytes (Staedtke et al., 2010) or be combined with fluorescent dyes (Zhao et al., 2011) with the development of modern pharmaceutical technologies. This review would mainly focus on recently developed novel approaches because the traditional methods have been summarized in many related literature (Van Eerdenbrugh et al., 2008; Malamatari et al., 2016).…”

Section: Tailor-made Drug Delivery Based On Nanocrystalsmentioning

confidence: 99%

Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery

Liu

Yin

et al. 2019

Drug Delivery

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Drug nanosuspensions/nanocrystals have been recognized as one useful and successful approach for drug delivery. Drug nanocrystals could be further decorated to possess extended functions (such as controlled release) and designed for special in vivo applications (such as drug tracking), which make best use of the advantages of drug nanocrystals. A lot of novel and advanced size reduction methods have been invented recently for special drug deliveries. In addition, some novel downstream processes have been combined with nanosuspensions, which have highly broadened its application areas (such as targeting) besides traditional routes. A large number of recent research publication regarding as nanocrystals focuses on above mentioned aspects, which have widely attracted attention. This review will focus on the recent development of nanocrystals and give an overview of regarding modification of nanocrystal by some new approaches for tailor-made drug delivery.

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Formulation of olanzapine nanosuspension based orally disintegrating tablets (ODT); comparative evaluation of lyophilization and electrospraying process as solidification techniques

Cited by 19 publications

References 35 publications

Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement

Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery

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