Formulation of Drug-Cyclodextrin Complexes

Loftsson, Þorsteinn

doi:10.1007/978-3-662-45013-0_14

Cited by 9 publications

(2 citation statements)

References 86 publications

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“…Sigurdadottir and Loftsson [19] demonstrated that cyclodextrins can act as a drug carrier, delivering lipophilic drugs to the skin surface where they can penetrate into the skin with an increased flux. Various studies have shown that CDs in topical formulations enhance drug penetration into and drug flux through the skin from aqueous vehicles [32]. Indeed, CDs are able to solubilize poorly soluble drugs in the aqueous external medium, increasing the drug concentration gradient over the lipophilic biological membrane [33,34].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Enhanced Skin Permeation and Retention of Imiquimod Loaded in β-Cyclodextrin Nanosponge Hydrogel

et al. 2019

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Imiquimod (IMQ) is an immune response modifier clinically used for the treatment of various topical diseases. However, its poor aqueous solubility and skin penetration capability make the topical delivery of IMQ a challenging task. This work aims at developing a nanomedicine-based topical formulation, carrying IMQ to control the scarring process for the treatment of aberrant wounds. For this purpose, IMQ was loaded in β-cyclodextrin-based nanosponges and dispersed in a hydrogel suitable for dermal application. The formulation was characterized in vitro and compared with IMQ inclusion complexes, with (2-hydroxy)propyl β-cyclodextrin(HPβCD) and carboxymethyl β-cyclodextrin (CMβCD) showing enhanced penetration properties. The hydrogel containing IMQ-loaded nanosponges could act as a drug reservoir and guarantee the sustained release of IMQ through the skin. A greater inhibitory effect on fibroblast proliferation was observed for IMQ loaded in nanosponges compared to the other formulations.

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Section: Resultsmentioning

confidence: 99%

In Vitro Enhanced Skin Permeation and Retention of Imiquimod Loaded in β-Cyclodextrin Nanosponge Hydrogel

et al. 2019

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“…This fact suggests a low risk of systemic toxicity [17]. Furthermore, Loftsson discussed the potential of cyclodextrins to improve the skin penetration of poorly soluble drugs formulated in aqueous carriers [18]. One of the most commonly used cyclodextrins is β-cyclodextrin, which consists of seven glucopyranose residues linked by 1,4-glycosidic linkages.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Resveratrol-Hydroxypropyl-β-Cyclodextrin Complexes into Hydrogel Formulation for Wound Treatment

Radeva,

Yordanov,

Spassova

et al. 2024

Gels

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Resveratrol could be applied in wound healing therapies because of its antioxidant, anti-inflammatory and antibacterial effects. However, the main limitation of resveratrol is its low aqueous solubility. In this study, resveratrol was included in hydroxypropyl-β-cyclodextrin complexes and further formulated in Pluronic F-127 hydrogels for wound treatment therapy. IR-spectroscopy and XRD analysis confirmed the successful incorporation of resveratrol into complexes. The wound-healing ability of these complexes was estimated by a scratch assay on fibroblasts, which showed a tendency for improvement of the effect of resveratrol after complexation. The antimicrobial activity of resveratrol in aqueous dispersion and in the complexes was evaluated on methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Candida albicans strains. The results revealed a twofold decrease in the MIC and stronger inhibition of the metabolic activity of MRSA after treatment with resveratrol in the complexes compared to the suspended drug. Furthermore, the complexes were included in Pluronic hydrogel, which provided efficient drug release and appropriate viscoelastic properties. The formulated hydrogel showed excellent biocompatibility which was confirmed via skin irritation test on rabbits. In conclusion, Pluronic hydrogel containing resveratrol included in hydroxypropyl-β-cyclodextrin complexes is a promising topical formulation for further studies directed at wound therapy.

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Getting Drugs Across Biological Barriers

et al. 2017

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The delivery of drugs to a target site frequently involves crossing biological barriers. The degree and nature of the impediment to flux, as well as the potential approaches to overcoming it, depend on the tissue, the drug, and numerous other factors. Here we present an overview of approaches that have been taken to crossing biological barriers, with special attention to transdermal drug delivery. Technology and knowledge pertaining to addressing these issues in a variety of organs could have a significant clinical impact.

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Formulation of Drug-Cyclodextrin Complexes

Cited by 9 publications

References 86 publications

In Vitro Enhanced Skin Permeation and Retention of Imiquimod Loaded in β-Cyclodextrin Nanosponge Hydrogel

In Vitro Enhanced Skin Permeation and Retention of Imiquimod Loaded in β-Cyclodextrin Nanosponge Hydrogel

Incorporation of Resveratrol-Hydroxypropyl-β-Cyclodextrin Complexes into Hydrogel Formulation for Wound Treatment

Getting Drugs Across Biological Barriers

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