Formulation of Dihydroartemisinin-Piperaquine (DHP) Generic Tablet  as Antimalarials Drug

Yunarto, Nanang; Isnawati, Ani; Aini, Nurul; Kurniatri, Arifayu Addiena; Adelina, Rosa; Setyorini, Herni Asih

doi:10.22435/jki.v6i1.5414.8-15

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“…A good tablet has a friability of no more than 1%. 23 The disintegration time of film-coated tablets needs to be determined to ensure that the tablet disintegrates swiftly enough to facilitate its dissolution in the gastrointestinal tract.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb

2024

TJNPR

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Catechins from gambir leaves have high antioxidant activity. 4 They can inhibit the activity of the HMG-CoA reductase and lipase enzymes. The inhibitory activity of catechins increases with their concentration, lowering total cholesterol levels. 5 The development of raw materials in the form of the ethyl acetate fraction of gambir leaf extract will improve the quality of raw materials due to the high catechin content in the ethyl acetate fraction of gambir (EAFG), cleaner physical appearance, lower water, and ash content. Catechin compounds are less stable in the presence of humidity and water, making them more easily oxidized. 6 Also, catechins are less stable to UV light and visible light. 7 One effort to increase the stability of catechins in EAFG is by formulating them in film-coated tablet dosage forms. Film-coated tablets can increase product stability by containing active substances sensitive to moisture and light and easily oxidized. 8 The present study aimed to produce and evaluate film-coated tablets made from the ethyl acetate fraction of gambir leaves. The quality of film-coated tablets was assessed based on their physicochemical properties, drug release, and stability during storage. Materials and Methods Preparation of gambir leaf extractThe extract of gambir leaves was prepared from plants obtained from Mungka District,

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Section: Resultsmentioning

confidence: 99%

Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb

2024

TJNPR

View full text Add to dashboard Cite

show abstract

Formulation of Dihydroartemisinin-Piperaquine (DHP) Generic Tablet as Antimalarials Drug

Cited by 1 publication

References 0 publications

Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb

Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb

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