Formulation of cyclodextrin inclusion complex-based orally disintegrating tablet of eslicarbazepine acetate for improved oral bioavailability

Desai, S. J.; Poddar, Aditi; Sawant, Krutika

doi:10.1016/j.msec.2015.09.019

Cited by 39 publications

(15 citation statements)

References 29 publications

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“…Lafutidine taste-masking granules were prepared by coating lafutidine granules with a taste-masking layer prepared by combining ethylcellulose (water-insoluble polymer) and hypromellose (water-soluble polymer), and ODTs were prepared by direct compression method using mannitol as a diluent, low-substituted hydroxypropyl cellulose as a disintegrant and sodium stearyl fumarate as a water-soluble lubricant. Desai et al [111] developed β-cyclodextrin (β-CD) solid dispersion-based ODTs of eslicarbazepine acetate (ESL), for improving the dissolution and providing rapid anti-epileptic action. ESL-β-CD solid dispersion was prepared by solvent evaporation method and then compressed into ODTs by direct compression, using superdisintegrants as crosspovidone, sodium starch glycolate, pregelatinzed starch and croscarmellose.…”

Section: Novel Formulations Of Oral Disintegrating Tabletsmentioning

confidence: 99%

Insights Into Formulation Technologies and Novel Strategies for the Design of Orally Disintegrating Dosage Forms: A Comprehensive Industrial Review

Agiba¹,

Eldin²

2019

Int J Pharm Pharm Sci

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Among the various routes of administration, the oral route remains the most convenient and commonly employed route for drug delivery. The oral conventional drug delivery systems have some drawbacks, such as possibility of gastrointestinal destruction of labile molecules, low absorption of macromolecules, slow onset of action, and unavoidable fluctuation in the concentration of drugs which can either lead to under-or over medication with concomitant adverse effects, especially for drugs with small therapeutic index. Therefore, it became essential to design novel oral drug delivery systems to achieve quick dissolution, absorption, rapid onset of action and reduction of drug dose. Among those novel drug delivery systems are oral disintegrating tablets (ODTs). The purpose of this review article is to report the recent advances in ODT systems with emphasis on their preparations, characterizations and applications. Also, it highlights future prospects and possible challenges in the development of an ideal ODT system.

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Section: Novel Formulations Of Oral Disintegrating Tabletsmentioning

confidence: 99%

Insights Into Formulation Technologies and Novel Strategies for the Design of Orally Disintegrating Dosage Forms: A Comprehensive Industrial Review

Agiba¹,

Eldin²

2019

Int J Pharm Pharm Sci

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“…[68] Desai et al formulated the cyclodextrin inclusion complex based orally disintegrating tablets of eslicarbazepine acetate and in-vivo studies showed 2 times higher bioavailability than marketed formulations. [69] Higher stability against hydrolysis and thermal Stability is the main parameter which should be kept in the mind of the researchers during the development of pharmaceutical formulations. Various types of stability studies of need to be determined which would modulate the shelf life of the formulation.…”

Section: Bioavailability Enhancementmentioning

confidence: 99%

“…[76] The formation of inclusion complexes of catechin with β-CD s showed the higher storage stability and provided more protection against temperature, oxygen, and light. [51] Sulfamethoxazole β-CD Enhance bioavailability and dissolution rate [67] Eslicarbazepine acetate β-CD Faster onset of action and higher bioavailability [69] Polylactic acid β-CD Improve the thermal expansion stability [72] Chimonanthus praecox β-CD Enhancement of antioxidant activity and thermal stability [73] Famotidine Carboxymethyl β-CD Improvement of chemical stability, oral bioavailability, and bitter taste [75] Astaxanthin HP-β-CD Storage stability and antioxidant activity [76] Catechin β-CD Protection of antioxidants, higher storage stability against temperature, oxygen, and light [51] α-tocopherol β-CD Higher antioxidant activity and better UV-light stability.…”

Section: Storage Stabilitymentioning

confidence: 99%

Untitled

Budhwar¹

2018

AJP

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Inclusion complexes have various applications in different fields of drug delivery and pharmaceutical industry due to their ability of complexation with guest molecules and enhancement of the physicochemical properties of guest molecules. Cyclodextrins and their derivatives have the ability to encapsulate the bioactive compounds into its cavity and protect these from the environmental conditions, improve the solubility, bioavailability, and other properties also. The aim of this review is to highlight the advantages of cyclodextrins in the enhancement of physicochemical properties of drugs (such as solubility, stability, bioavailability, permeability, and others), different methods for production and various characterization techniques used for evaluation of complexes. Applications of cyclodextrin complexes in pharmaceutical and other fields are also explained here with examples. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems accompanied with the delivery of different novel drugs through various delivery routes.

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“…This is suitable for people with swallowing difficulties. Moreover, ODTs can give rapid onset of action, improve bioavailability due to rapid dissolution and pre-gastric absorption, which reduced the number of drugs that undergo first-pass metabolism [13].…”

Section: Introductionmentioning

confidence: 99%

EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN-β-CYCLODEXTRIN INCLUSION COMPLEX

Purnamasari

Saputra

2020

Int J App Pharm

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Objective: This study aims to determine the effect of the inclusion complex formation of ibuprofen (IB) with β-cyclodextrin (β-CD) in improving water solubility and taste masking as well as to study the effect of the combined use of super disintegrants in IB-β-CD ODT (Orally disintegrating tablet). Methods: IB-β-CD inclusion complex was prepared by spray drying technique with a 1:1 molar ratio. ODTs were prepared by the direct compression method using various ratios of Ac-Di-Sol® and Kollidon® CL as super disintegrant. The inclusion complex was characterized using spectroscopy FT-IR (Fourier-transform infrared) and DSC (Differential Scanning Calorimetry). The physical properties and dissolution rate of ODTs were evaluated. Dissolved drug concentration at 60 min (Q60) and Dissolution Efficiency (DE60) was calculated using the dissolution test result. Results: The unpleasant taste of IB had been successfully masked by IB-β-CD. Formula 1 was observed having 14.5 sec of disintegration, fastest compared to the other formulas. Moreover DE60 value of formula I was higher than the other formulas (113.45). Conclusion: IB-β-CD Inclusion complex prepared by spray drying method (1: 1) increased the water solubility and masked the unpleasant taste compared to IB moreover combination of Ac-Di-Sol® and Kollidon® CL increased ODT dissolution rate.

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Formulation of cyclodextrin inclusion complex-based orally disintegrating tablet of eslicarbazepine acetate for improved oral bioavailability

Cited by 39 publications

References 29 publications

Insights Into Formulation Technologies and Novel Strategies for the Design of Orally Disintegrating Dosage Forms: A Comprehensive Industrial Review

Insights Into Formulation Technologies and Novel Strategies for the Design of Orally Disintegrating Dosage Forms: A Comprehensive Industrial Review

Untitled

EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN-β-CYCLODEXTRIN INCLUSION COMPLEX

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