EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN-β-CYCLODEXTRIN INCLUSION COMPLEX

Purnamasari, Nur Aini Dewi; Saputra, Pratama Anggi

doi:10.22159/ijap.2020v12i2.34848

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…FTIR, HPLC, DSC, PXRD [25] Ibuprofen β-cyclodextrin No detailed information provided. FTIR, DSC, UV-VIS [58] Aceclofenac β-cyclodextrin A dose of ASTMGA equal to 100 mg of aceclofenac was applied to the tongues of three healthy male volunteers while not drinking any water. After 1 min, the participants were asked to record the amount of bitterness, which served as the basis for taste rating.…”

Section: Uv-vis [54]mentioning

confidence: 99%

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Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes

Adamkiewicz,

Szeleszczuk

2023

Molecules

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It is widely recognized that many active pharmaceutical ingredients (APIs) have a disagreeable taste that affects patient acceptability, particularly in children. Consequently, developing dosage forms with a masked taste has attracted a lot of interest. The application of cyclodextrins as pharmaceutical excipients is highly appreciated and well established, including their roles as drug delivery systems, solubilizers and absorption promoters, agents that improve drug stability, or even APIs. The first work describing the application of the taste-masking properties of CDs as pharmaceutical excipients was published in 2001. Since then, numerous studies have shown that these cyclic oligosaccharides can be effectively used for such purposes. Therefore, the aim of this review is to provide insight into studies in this area. To achieve this aim, a systematic evaluation was conducted, which resulted in the selection of 67 works representing both successful and unsuccessful works describing the application of CDs as taste-masking excipients. Particular attention has been given to the methods of evaluation of the taste-masking properties and the factors affecting the outcomes, such as the choice of the proper cyclodextrin or guest–host molar ratio. The conclusions of this review reveal that the application of CDs is not straightforward; nevertheless, this solution can be an effective, safe, and inexpensive method of taste masking for pharmaceutical purposes.

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Section: Uv-vis [54]mentioning

confidence: 99%

“…Ibuprofen: In [58], ibuprofen (IB)-β-CD inclusion complex was prepared by spray drying technique with a 1:1 molar ratio. ODTs were created using the direct compression technique and different superdisintegrant ratios of Ac-Di-Sol ® and Kollidon ® CL.…”

Section: Musculo-skeletal System Drugs (M)mentioning

confidence: 99%

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes

Adamkiewicz,

Szeleszczuk

2023

Molecules

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“…10 These include acetyl salicylic acid, 11 piroxicam, 12 ketoconazole, 13 ibuprofen, 14 ketoprofen, 15 tolbutamide, 16 ALB. 17,18 Nanosponges (NS) are biocompatible and nanoporous carriers made from CD using crosslinkers such as DPC, Pyromellitic Dianhydride (PMDA), Carbonyl Diimidazole (CDI) and hexamethylene diisocynate. 19,20 These carriers have the ability to form inclusion complexes and non-inclusion complexes with both hydrophilic and lipophilic drugs.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Solubility of Albendazole by Inclusion Complexation with Nanosponges and β-Cyclodextrin

Rao,

Sakharwade

2024

Ind. J. Pharm. Edu. Res

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Aim: Objective of work was to compare role of β-Cyclodextrin (β-CD) and Nanosponges (NS) prepared with different cross-linking ratios and different drug loading ratios to enhance solubility and dissolution rate of Albendazole (ALB). Materials and Methods: Diphenyl Carbonate (DPC) was used as cross-linker for preparing NS with various β-CD and DPC ratios (1:2 and 1:4). Solvent evaporation was used to make binary complex. ALB and NS were dissolved in Dichloromethane (DCM) in 1:1 and 1:2 ratios and triturated until solvent evaporated. Phase solubility, saturation solubility and in vitro dissolution studies were performed. Solid state characterization as well as spectral and thermal analyses was done. Results: Stability constant for complexes ALB-β-CD, ALB-NS (1:2 ratios) and ALB-NS (1:4 ratios) were found to be 1715M -1 ±18.3, 1902M -1 ±29.5 and 1945M -1 ±30.1 respectively. Maximum solubility of all complexes was observed in fed state simulated intestinal fluid (FeSSIF). The increase was to the tune of 3-8 folds for all binary complexes at 1:1 and 1: 2 drug loading ratios. Dissolution rate increased by 47%-67% for drug loading ratio 1:1 and 55-71% for drug loading ratio 1:2 in FeSSIF in 150 min. Conclusion: β-CD based NS improved solubility of ALB. Presence of drug in molecular form in nanochannels and amorphization were responsible for increase in solubility. Nanosponges prepared in ratio 1:4 and drug loading in ratio 1:2 showed highest increase in solubility and dissolution rate.

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“…Organic cyclodextrin cyclic oligosaccharide with 6-(α-cyclodextrin), 7-(βcyclodextrin) either 8-glucopyranose unit attached to the macrocycle by α-1 4-glycoside bonds. It has an outer layer of hydrophilic and a hydrophobic cavity [5].…”

Section: Introductionmentioning

confidence: 99%

IMPROVEMENT AND ESTIMATION OF ORALLY DISINTEGRATING TABLETS CONTAINING PILOCARPINE 2-Hydroxy PROPYL Β-Cyclodextrin INCLUSION COMPLEX BY RESPONSE SURFACE METHODOLOGY

et al. 2021

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Objective: The study aimed to develop and evaluate an orally disintegrating tablet that contains pilocarpine and 2-hydroxy propyl β-cyclodextrin as an inclusion complex that is prepared by lyophilization used for treatment for dry mouth. Pilocarpine is utilized to treat dry mouth disorder. The inclusion complex lowers the taste of pilocarpine through the oral mucosa by the use of 2-hydroxy propyl β-cyclodextrin. Methods: The in vitro release from the insertion complex is also been studied. The parameters like differential scanning calorimetry (DSC), Fourier transformer infrared spectroscopy (FTIR), X-ray diffraction (XRD), and morphological study have been evaluated. The design of an experiment is carried out based on the concentration of croscarmellose sodium (CCS) and microcrystalline cellulose (MCC). Evaluation of the prepared orally disintegrating tablets have been carried out by different test methods like weight variation, thickness, drug content, disintegration, and in vitro dissolution study. Results: Orally disintegrating tablets are studied by utilizing the immediate pressure technique. Pilocarpine indicates the anhydrous crystalline medication, displaying sharp endothermic top at 120.2 °C, bend of 2-HPβCD demonstrates an exceptionally wide endothermal wonder among 55-100 °C for DSC. In pilocarpine spectra, characteristic band of aromatic C-H stretch at 3277 cm-1, C=C stretching at 1608 cm-1, C-N stretching at 1445 cm-1 and methoxy (CH3-O-) stretch at 2921 cm-1 was observed. The investigation shows that tablet hardness of 4.3N, breaking downtime of 12 sec and mean disintegration time is 1.562 min. Conclusion: The different diluents and super disintegrating have been applied for the quick elevation of dry mouth that helps us for patient compliance.

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EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN-β-CYCLODEXTRIN INCLUSION COMPLEX

Cited by 4 publications

References 24 publications

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes

Enhancement of Solubility of Albendazole by Inclusion Complexation with Nanosponges and β-Cyclodextrin

IMPROVEMENT AND ESTIMATION OF ORALLY DISINTEGRATING TABLETS CONTAINING PILOCARPINE 2-Hydroxy PROPYL Β-Cyclodextrin INCLUSION COMPLEX BY RESPONSE SURFACE METHODOLOGY

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