Formulation of chloroaluminum phthalocyanine incorporated into PS-b-PAA diblock copolymer nanomicelles

Vilsinski, Bruno H.; Witt, Maria Alice; Barbosa, Patrícia Magalhães; Montanha, Maiara Camotti; Nunes, Cátia S.; Bellettini, Ismael C.; Castro, Lidiane Vizioli de; Sato, Francielle; Baesso, Mauro Luciano; Muniz, Edvani C.; Caetano, Wilker

doi:10.1016/j.molliq.2018.09.034

Cited by 18 publications

(19 citation statements)

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“…There are several studies in the literature on the PS–PAA morphologies in dispersions; however, most of them were performed in organic solvent/water mixtures. Vilsinski et al showed, using conventional TEM microscopy, that the PS–PAA 70.500:13.000 copolymer can form monodisperse micelle-like nanostructures with an average size of less than 50 nm, 11 which is consistent with our observations. Self-aggregation of PS–PAA copolymers into micelles with the formation of the PS core and the PAA corona was also demonstrated using molecular dynamics (MD) simulations, 37 which showed that the corona-forming PAA blocks in the protonated state adopt coiled conformations while in the fully dissociated states have extended conformations.…”

Section: Results and Discussionsupporting

confidence: 92%

“…In addition, a recent study has shown that PS–PAA NPs are a promising nanostructured carrier of hydrophobic photosensitizers used in photodynamic therapy (PDT). 11 The authors showed that PS- b -PAA NPs are not only biocompatible but also have the ability to permeate the superficial layer of the dermis and therefore are suitable for both topical and intravenous administration of PDT photosensitizers. All these studies demonstrate a significant potential of using PS–PAA NPs in drug delivery and the need for in-depth research of the interactions between PS–PAA and hydrophobic biologically active agents.…”

Section: Introductionmentioning

confidence: 99%

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Encapsulation of Curcumin in Polystyrene-Based Nanoparticles—Drug Loading Capacity and Cytotoxicity

et al. 2021

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Nanoparticles made of amphiphilic block copolymers are commonly used in the preparation of nano-sized drug delivery systems. Poly(styrene)– block – poly(acrylic acid) (PS–PAA) copolymers have been proposed for drug delivery purposes; however, the drug loading capacity and cytotoxicity of PS–PAA nanoparticles are still not fully recognized. Herein, we investigated the accumulation of a model hydrophobic drug, curcumin, and its spatial distribution inside the PS–PAA nanoparticles. Experimental methods and atomistic molecular dynamics simulations were used to understand the molecular structure of the PS core and how curcumin molecules interact and organize within the PS matrix. The hydrophobic core of the PS–PAA nanoparticles consists of adhering individually coiled polymeric chains and is compact enough to prevent post-incorporation of curcumin. However, the drug has a good affinity for the PS matrix and can be efficiently enclosed in the PS–PAA nanoparticles at the formation stage. At low concentrations, curcumin is evenly distributed in the PS core, while its aggregates were observed above ca. 2 wt %. The nanoparticles were found to have relatively low cytotoxicity to human skin fibroblasts, and the presence of curcumin further increased their biocompatibility. Our work provides a detailed description of the interactions between a hydrophobic drug and PS–PAA nanoparticles and information on the biocompatibility of these anionic nanostructures which may be relevant to the development of amphiphilic copolymer-based drug delivery systems.

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Section: Results and Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Encapsulation of Curcumin in Polystyrene-Based Nanoparticles—Drug Loading Capacity and Cytotoxicity

et al. 2021

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“…In vitro tests using the Caco-2 human colon carcinoma cell line incubated with ClAlPc diblock nanomicelles at different Pc concentrations showed cellular damage after 30 min of LED radiation (663 nm, fluence of 1.62 μJ cm -2 ), but no cytotoxicity in the dark assays. Thus, the ClAlPc diblock copolymer produced promising nanomicelles suitable for incorporating the hydrophobic ClAlPc photosensitizer and subsequent use in the PDT [ 71 ]. Even more exciting, Almeida et al developed a ClAlPc-loaded Nanostructured Lipid Carrier (NLC), a mixture of solid and liquid lipids dispersed in an aqueous surfactant solution, composed of 40% of oleic acid that resulted in approximately 99% reduction in BF16-F10 melanoma cell viability after light radiation.…”

Section: Chemical Approaches For Transdermal Deliverymentioning

confidence: 99%

Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies

et al. 2021

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Photodynamic therapy is one of the more unique cancer treatment options available in today’s arsenal against this devastating disease. It has historically been explored in cutaneous lesions due to the possibility of focal/specific effects and minimization of adverse events. Advances in drug delivery have mostly been based on biomaterials, such as liposomal and hybrid lipoidal vesicles, nanoemulsions, microneedling, and laser-assisted photosensitizer delivery systems. This review summarizes the most promising approaches to enhancing the photosensitizers’ transdermal delivery efficacy for the photodynamic treatment for cutaneous pre-cancerous lesions and skin cancers. Additionally, discussions on strategies and advantages in these approaches, as well as summarized challenges, perspectives, and translational potential for future applications, will be discussed.

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“…Block copolymer nanoassemblies offer the unique possibility to protect the photosensitizer in a hydrophobic environment (as described in Figure 3) and to prevent the aggregation. At the same time, they improve the biodistribution, pharmacokinetics and photochemi- [30,[32][33][34][35]57] poly(ethylene oxide)-block-poly [2-(methylacryloyl)ethylnicotinate] -osteosarcoma in vitro and in vivo [43] poly(styrene)-block-poly(acrylic acid) -adenocarcinoma in vitro [58] cal reactivity of the photosensitizer. Thus, typical PDT side effects, i.e., patient skin photosensitivity, can be avoided.…”

Section: Block Copolymers Used For Vectorization Of Photosensitizersmentioning

confidence: 99%

“…In a recent study, Vilsinki et al [58] used polyacrylate as a hydrophilic block, effectively rendering the self-assemblies highly negatively charged at physiological pH values. Indeed, negatively charged nanoparticles are known to be capable of evading the mononuclear phagocyte system and enjoy prolonged blood circulation [58,110].…”

Section: The Hydrophilic Blocksmentioning

confidence: 99%

Rational design of block copolymer self-assemblies in photodynamic therapy

Demazeau¹,

Gibot²,

Mingotaud³

et al. 2020

Beilstein J. Nanotechnol.

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Photodynamic therapy is a technique already used in ophthalmology or oncology. It is based on the local production of reactive oxygen species through an energy transfer from an excited photosensitizer to oxygen present in the biological tissue. This review first presents an update, mainly covering the last five years, regarding the block copolymers used as nanovectors for the delivery of the photosensitizer. In particular, we describe the chemical nature and structure of the block copolymers showing a very large range of existing systems, spanning from natural polymers such as proteins or polysaccharides to synthetic ones such as polyesters or polyacrylates. A second part focuses on important parameters for their design and the improvement of their efficiency. Finally, particular attention has been paid to the question of nanocarrier internalization and interaction with membranes (both biomimetic and cellular), and the importance of intracellular targeting has been addressed.

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Formulation of chloroaluminum phthalocyanine incorporated into PS-b-PAA diblock copolymer nanomicelles

Cited by 18 publications

References 50 publications

Encapsulation of Curcumin in Polystyrene-Based Nanoparticles—Drug Loading Capacity and Cytotoxicity

Encapsulation of Curcumin in Polystyrene-Based Nanoparticles—Drug Loading Capacity and Cytotoxicity

Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies

Rational design of block copolymer self-assemblies in photodynamic therapy

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