Formulation of cashew nut shell liquid (CSNL) nanoemulsion, a potent inhibitor of human MCF-7 breast cancer cell proliferation

Abstract

Cashew nut shell liquid (CSNL) nanoemulsion has been formulated and its cytotoxic activity was determined using human breast cancer cells (MCF-7) adopting MTT assay and established staining techniques. MCF-7 cells treated with CSNL nanoemulsion suffered loss of viability and death mostly through apoptosis and/or necrosis as evidenced by the changes in the nuclear morphology and cytoplasmic features. The IC 50 value of 48-h treatment groups fall in the range of 88 ± 14.2 ll/ml. In conclusion, the antiproliferative and morphological effects of CSNL nanoemulsion appear to be target-specific killing of cells which gives further lead to study apoptotic pathways as target for breast cancer therapy. This study has provided a scientific basis for the anti-tumor property of CSNL nanoemulsion with respect to breast cancer.

A green method for the production of an efficient bioimaging nanotool

“…Several data proved that CNSL and its derivatives possess interesting in vitro and in vivo biological functions, including antioxidant, antimicrobial, anti-cancer and larvicidal activities. [16][17][18][19][20][21] CA is able to form a stable nanovesicle dispersion upon combination with cholesterol, 22,23 showing good antioxidant and cytotoxic properties, 24 and a potential stabilization capability towards the encapsulated molecules. 25 A new challenge nowadays is, hence, the possibility of creating a biocompatible drug delivery system starting from waste materials, which can also be potentially used as a bioimaging tool.…”

Cardanol-based green nanovesicles with antioxidant and cytotoxic activities

“…[11À14] Apart from current industrial uses, it has been demonstrated that the cashew nut deriving oils may exert antioxidant,[15À17] antifungal, [18] antibacterial [19] and larvicidal [20,21] activities. Moreover, recent studies showed the antitumour efficacy of CNSL-nanoemulsions towards breast cancer [22] as well as the biological activities of CA itself, as acetylcholinesterase inhibition against Alzheimer disease [23] and antiproliferative/cytotoxic activity [24] on cancer cell lines, were also studied.…”

Valorization of Native Nuts from Brazil and Their Coproducts

“…Nanoemulsions prepared from cashew nut shell liquid showed cytotoxicity against human breast cancer cell line MCF-7. The cells treated with the nanoemulsion presented reduced viability, primarily through apoptosis or necrosis [46]. Cashew nut has also demonstrated a positive impact on cholesterol levels and systolic blood pressure.…”