Formulation of acyclovir (core)-dexpanthenol (sheath) nanofibrous patches for the treatment of herpes labialis

Kazsoki, Adrienn; Palcsó, Barnabás; Alpár, Alán; Snoeck, Robert; Andrei, Gracíela; Zelkó, Romána

doi:10.1016/j.ijpharm.2021.121354

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…Successful drug delivery needs supports from both pharmaceutical excipients, pharmaceutical techniques, and their effective combinations [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. To a certain extent, the fields of pharmaceutics and drug delivery rely heavily on the inputs of materials sciences (new excipients) and engineering (new techniques) [ 8 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

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One of the most important trends in developments in electrospinning is to combine itself with traditional materials production and transformation methods to take advantage of the unique properties of nanofibers. In this research, the single-fluid blending electrospinning process was combined with the casting film method to fabricate a medicated double-layer hybrid to provide a dual-phase drug controlled release profile, with ibuprofen (IBU) as a common model of a poorly water-soluble drug and ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) K60 as the polymeric excipients. Electrospun medicated IBU-PVP nanofibers (F7), casting IBU-EC films (F8) and the double-layer hybrid films (DHFs, F9) with one layer of electrospun nanofibers containing IBU and PVP and the other layer of casting films containing IBU, EC and PVP, were prepared successfully. The SEM assessments demonstrated that F7 were in linear morphologies without beads or spindles, F8 were solid films, and F9 were composed of one porous fibrous layer and one solid layer. XRD and FTIR results verified that both EC and PVP were compatible with IBU. In vitro dissolution tests indicated that F7 were able to provide a pulsatile IBU release, F8 offered a typical drug sustained release, whereas F9 were able to exhibit a dual-phase controlled release with 40.3 ± 5.1% in the first phase for a pulsatile manner and the residues were released in an extended manner in the second phase. The DHFs from a combination of electrospinning and the casting method pave a new way for developing novel functional materials.

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Section: Introductionmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

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“…In the related study of Kazsoki et al, the core/shell nanofibers of PVA/PVP and hypromellose were used just to obtain this effect. 46 The control sample of CA/acyclovir nanofibers released just 7.2 ± 1.4% and 7.6 ± 0.7% of drug molecules at pH 7.4 and 5.4, respectively, in 30 min (Figure 7C) and reached the maximum released amount of 38.1 ± 1.4% and 29.3 ± 4.9% in 1−2 days (Figure 7B). In comparison with HPβCD/acyclovir nanofibers, acyclovir existed in the crystal state in CA/acyclovir, which was also confirmed by XRD and DSC findings (Figure 4).…”

Section: Dissolution/swelling and In Vitro Releasementioning

confidence: 99%

Green Synthesis of Polycyclodextrin/Drug Inclusion Complex Nanofibrous Hydrogels: pH-Dependent Release of Acyclovir

Celebioglu,

Uyar

2023

ACS Appl. Bio Mater.

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The development of an approach or a material for wound healing treatments has drawn a lot of attention for decades and has been an important portion of the research in the medical industry. Especially, there is growing interest and demand for the generation of wound care products using eco-friendly conditions. Electrospinning is one of these methods that enables the production of nanofibrous materials with attractive properties for wound healing under mild conditions and by using sustainable sources. In this study, starch-derived cyclodextrin (hydroxypropyl-β-cyclodextrin (HPβCD)) was used both for forming an inclusion complex (IC) with acyclovir, a well-known antiviral drug, and for electrospinning of free-standing nanofibers. The nanofibers were produced in an aqueous system, without using a carrier polymer matrix and toxic solvent/chemical. The ultimate HPβCD/acyclovir-IC nanofibers were thermally cross-linked by using citric acid, listed in the generally regarded as safe (GRAS) category by the US Food and Drug Administration (FDA). The cross-linked HPβCD/acyclovir-IC nanofibers displayed stability in aqueous medium. The hydrogel-forming feature of nanofibers was confirmed with their high swelling profile in water in the range of ∼610–810%. Cellulose acetate (CA)/acyclovir nanofibers were also produced as the control sample. Due to inclusion complexation with HPβCD, the solubility of acyclovir was improved, so cross-linked HPβCD/acyclovir-IC nanofibrous hydrogels displayed a better release performance compared to CA/acyclovir nanofibers. Here, a pH-dependent release profile was obtained (pH 5.4 and pH 7.4) besides their attractive swelling features. Therefore, the cross-linked HPβCD/acyclovir-IC nanofibrous hydrogel can be a promising candidate as a wound healing dressing for the administration of antiviral drugs by holding the unique properties of CD and electrospun nanofibers.

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“…To favor the inclusion and to preserve and tune at the same time the release of the loaded drugs or bioactive molecules, the electrospinning set-up can be implemented using coaxial needles, − which allow to produce fibers characterized by a radial and concentric alignment along the transversal section of the fiber, thus defined “core–shell”. , The miscibility of the polymers employed is of pivotal importance since in the presence of immiscible or semi-miscible solutions a more stable Taylor cone is created; moreover, the compatibility of the solutions, the polymer ratio, and the differential flow rate between the core and shell are relevant parameters in the production of well-defined coaxial fibers. − The core–shell structure can enable a sustained and/or two-stage release, avoiding the burst and rapid release of the drugs. Moreover, multiple drugs and bioactive moieties can be differentially incorporated into the core or shell layer, depending on the stability of the selected compound and on the desired release kinetics. ,− …”

Section: Introductionmentioning

confidence: 99%

“…Moreover, multiple drugs and bioactive moieties can be differentially incorporated into the core or shell layer, depending on the stability of the selected compound and on the desired release kinetics. 13 , 30 − 32 …”

Section: Introductionmentioning

confidence: 99%

Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core–Shell Electrospun Membranes: A Proof of Concept

Gruppuso

Guagnini

Musciacchio

et al. 2022

ACS Appl. Mater. Interfaces

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The employment of coaxial fibers for guided tissue regeneration can be extremely advantageous since they allow the functionalization with bioactive compounds to be preserved and released with a long-term efficacy. Antibacterial coaxial membranes based on poly-ε-caprolactone (PCL) and rifampicin (Rif) were synthesized here, by analyzing the effects of loading the drug within the core or on the shell layer with respect to non-coaxial matrices. The membranes were, therefore, characterized for their surface properties in addition to analyzing drug release, antibacterial efficacy, and biocompatibility. The results showed that the lower drug surface density in coaxial fibers hinders the interaction with serum proteins, resulting in a hydrophobic behavior compared to non-coaxial mats. The air-plasma treatment increased their hydrophilicity, although it induced rifampicin degradation. Moreover, the substantially lower release of coaxial fibers influenced the antibacterial efficacy, tested against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Indeed, the coaxial matrices were inhibitory and bactericidal only against S. aureus, while the higher release from non-coaxial mats rendered them active even against E. coli. The biocompatibility of the released rifampicin was assessed too on murine fibroblasts, revealing no cytotoxic effects. Hence, the presented coaxial system should be further optimized to tune the drug release according to the antibacterial effectiveness.

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Formulation of acyclovir (core)-dexpanthenol (sheath) nanofibrous patches for the treatment of herpes labialis

Cited by 16 publications

References 27 publications

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Green Synthesis of Polycyclodextrin/Drug Inclusion Complex Nanofibrous Hydrogels: pH-Dependent Release of Acyclovir

Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core–Shell Electrospun Membranes: A Proof of Concept

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