Formulation development of liposomal coffee extracts and investigation of their antioxidant capacities

Macit, Meltem; Eyüpoğlu, Ozan Emre; Macit, Çağlar; Duman, Gülengül

doi:10.1016/j.jddst.2021.102605

Cited by 10 publications

(5 citation statements)

References 29 publications

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“…Silymarin is one of the most effective hepatoprotective compounds found in Silybum marianum (Milk thistle), belonging to the Asteraceae family. Silymarin is a mixture of seven flavonoids, which are called silybin A, silybin B, isosilybin A and isosilybin B, silydianin, silychristin and taxifolin [ 81 , 82 ]. They can reverse hepatic fibrosis in vivo by downregulating TGF-β and inhibiting the secretion of α-SMA and CoI-l [ 38 ].…”

Section: Dietary Polyphenols Affect Hepatic Fibrosis Through Multiple...mentioning

confidence: 99%

“…They can reverse hepatic fibrosis in vivo by downregulating TGF-β and inhibiting the secretion of α-SMA and CoI-l [ 38 ]. The data aggregated from this study clearly demonstrate that the nanoparticle formulation of silymarin is more effective than the pure silymarin formulation, including controlled release, minimal cytotoxicity, lower dose, targeted entry into hepatic stellate cells for the treatment of hepatic fibrosis [ 82 , 83 , 84 ]. Curcumin, a polyphenol present in the roots of curcumin spp., reduces the phosphorylation levels of JNK and Smad3 and can reverse Smad7 levels [ 33 ].…”

Section: Dietary Polyphenols Affect Hepatic Fibrosis Through Multiple...mentioning

confidence: 99%

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Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

Chang,

Huang,

et al. 2023

Molecules

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The development of liver fibrosis is a result of chronic liver injuries may progress to liver cirrhosis and liver cancer. In recent years, liver fibrosis has become a major global problem, and the incidence rate and mortality are increasing year by year. However, there are currently no approved treatments. Research on anti-liver-fibrosis drugs is a top priority. Dietary polyphenols, such as plant secondary metabolites, have remarkable abilities to reduce lipid metabolism, insulin resistance and inflammation, and are attracting more and more attention as potential drugs for the treatment of liver diseases. Gradually, dietary polyphenols are becoming the focus for providing an improvement in the treatment of liver fibrosis. The impact of dietary polyphenols on the composition of intestinal microbiota and the subsequent production of intestinal microbial metabolites has been observed to indirectly modulate signaling pathways in the liver, thereby exerting regulatory effects on liver disease. In conclusion, there is evidence that dietary polyphenols can be therapeutically useful in preventing and treating liver fibrosis, and we highlight new perspectives and key questions for future drug development.

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Section: Dietary Polyphenols Affect Hepatic Fibrosis Through Multiple...mentioning

confidence: 99%

Section: Dietary Polyphenols Affect Hepatic Fibrosis Through Multiple...mentioning

confidence: 99%

Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

Chang,

Huang,

et al. 2023

Molecules

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“…The high-pressure homogenizer microfluidizer (M-110EH-30 Microfluidizer High Pressure Homogenizer, Westwood, USA) was used to mechanically prepare liposomes as secondary homogenization. The microfluidization technique was applied on this mixture for three cycles, under a 15000 psi pressure (Macit et al, 2021). After that, to improve its stability and eligibility for encapsulation, the resultant liposome dispersion was lyophilized (Christ Alpha 1-4 LSC Freeze-Dryer, Harz, Germany).…”

Section: Preparation Of Terebinth Extracts and Their Nanoliposomal Formsmentioning

confidence: 99%

The preparation, characterization, and antibacterial activity evaluation of nanoliposomes incorporated with terebinth extract

YILMAZ,

NİZAM,

MACİT

et al. 2023

Biotech Studies

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Nanoliposomes are drug release systems that increase bioavailability and are used for encapsulation of therapeutic active ingredients. Terebinth, which is a medicinal plant that grows in many parts of Türkiye, has antibacterial, antioxidant, and anti-inflammatory activity. The antibacterial activity of nanoliposomes incorporated with ethanol extract of terebinth leaves (TLE) was investigated to determine the effects of formulation. The nanoliposome formulation was prepared in two steps which were high pressure and high intensity homogenization techniques. Characterization parameters (zeta potential, particle size and distribution, polydispersity index, and encapsulation efficiency) were determined. After third cycle of microfluidization, the zeta potential charge of nanoliposome dispersion was measured -66.6 mV and 91.13 nm in size. The PDI was 0.231. Also, the nanoliposome encapsulation efficiency was calculated as 91.90%. The TLE was encapsulated with nanoliposomes and their antibacterial activity was examined by disk diffusion and minimum inhibition concentration tests against Escherichia coli ATTC 25922 and Staphylococcus aureus ATTC 25923. Nanoliposome encapsulated TLE (NLTLE) has antibacterial activity against S. aureus ATTC 25923. While NLTLE has less active substance, it displays the same antibacterial activity as TLE.

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“…The primary steroid typically employed in liposome synthesis is cholesterol, which has the effect of decreasing membranous permeability towards hydrophilic molecules, enhancing the fluidity of the phospholipid bilayer, and increasing the stability of the bilayer in the biological environment [23,24]. Liposomes of green coffee and medium-roasted coffee extracts have been separately prepared and have strong antioxidant properties [25]. In another study, spent coffee grounds maintained their antioxidant activity through the supercritical assisted liposome production method [26].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Anti-Aging Effect of Coffee Berry Nanoliposomes

Saewan,

Jimtaisong,

Panyachariwat

et al. 2023

Molecules

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Encapsulation of bioactive compounds in the liposome system provides several advantages, such as enhancing the stability and lowering the toxicity of active compounds. Coffee berry extract (CBE) has previously been established to have in vitro anti-aging properties and to retard the aging of human skin. The purposes of this study were to encapsulate CBE in nanoliposomes and to assess its stability and in vitro anti-aging potential in human dermal fibroblasts (HDF), as well as in healthy human skin. In the HDF model, anti-aging potential was determined by nitric oxide (NO) and collagenase inhibition assays and a superoxide dismutase (SOD) activity assay, whereas in healthy human skin (in vivo), the skin elasticity and brightness were examined. First, liposomal CBE (L-CBE) was created with a particle size of 117.33 ± 2.91 nm, a polydispersity index (PDI) of 0.36 ± 0.03, and a zeta potential of −56.13 ± 1.87 mV. The percentages of encapsulation efficacy (%EE) and loading efficacy (%LE) were 71.26 ± 3.12% and 2.18 ± 0.18%, respectively. After undergoing a 12-week stability test, the L-CBE retained more phenolic content than the free CBE when stored at 4 °C, room temperature, and 45 °C. Compared to free CBE, the L-CBE demonstrated a more consistent, elevated, and prolonged release of phenolics from the lipid system. In human dermal fibroblasts, L-CBE showed lower toxicity, and at its maximum nontoxic concentration (10 mg/mL), it exhibited slightly higher anti-aging effects than CBE, including NO inhibition, enhanced SOD activity, and anti-collagenase activities. In clinical trials (30 volunteer subjects), none of the participants’ skin was irritated when the L-CBE, the CBE, or base creams were applied. After 2 weeks of application, the L-CBE and CBE creams both demonstrated an improvement in skin elasticity and a reduction in melanin levels, and after 4 weeks, L-CBE cream showed a significantly greater improvement in skin elasticity and lightening. The results demonstrate that the encapsulation of the CBE in liposomal systems could increase its stability and skin penetration, reduce its toxicity, and maintain its anti-aging effect, which is powerful enough to be exploited in anti-aging and whitening agents for application in cosmetics and cosmeceuticals.

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Formulation development of liposomal coffee extracts and investigation of their antioxidant capacities

Cited by 10 publications

References 29 publications

Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

The preparation, characterization, and antibacterial activity evaluation of nanoliposomes incorporated with terebinth extract

In Vitro and In Vivo Anti-Aging Effect of Coffee Berry Nanoliposomes

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