Formulation development and in vitro evaluation of transferrin-conjugated liposomes as a carrier of ganciclovir targeting the retina

Asasutjarit, Rathapon; Managit, Chittima; Phanaksri, Teva; Treesuppharat, Worapapar; Fuongfuchat, Asira

doi:10.1016/j.ijpharm.2020.119084

Cited by 41 publications

(20 citation statements)

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“…The characteristic bands at a wavenumber of 1740 cm −1 was assigned for the C=O stretch of the ester bond between the fatty acid and the head group of phospholipids consisting of lecithin. The strong bands at wavenumbers of 2853 cm −1 and 2920 cm −1 also responded to the CH 2 symmetric and symmetric stretch mode, respectively, in such phospholipid molecules [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

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Optimization of Production Parameters for Andrographolide-Loaded Nanoemulsion Preparation by Microfluidization and Evaluations of Its Bioactivities in Skin Cancer Cells and UVB Radiation-Exposed Skin

et al. 2021

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Andrographolide (AG) is an active compound isolated from Andrographis paniculata (Family Acanthaceae). Although it possesses beneficial bioactivities to the skin, there is insufficient information of its applications for treatment of skin disorders due to low water solubility leading to complications in product development. To overcome the problem, an AG-loaded nanoemulsion (AG-NE) was formulated and prepared using a microfluidization technique. This study aimed to investigate the effect of pressure and the number of homogenization cycles (factors) on droplet size, polydispersity index and zeta potential of AG-NE (responses) and to determine the effect of AG-NE on skin cancer cells and UVB irradiation-induced skin disorders in rats. Relationships between factors versus responses obtained from the face-centered central composite design were described by quadratic models. The optimum value of parameters for the production of optimized AG-NE (Op-AG-NE) were 20,000 psi of pressure and 5 homogenization cycles. Op-AG-NE showed promising cytotoxicity effects on the human malignant melanoma- (A375 cells) and non-melanoma cells (A-431 cells) via apoptosis induction with a high selectivity index and also inhibited intracellular tyrosinase activity in the A375 cells. Op-AG-NE could reduce melanin index and healed UVB irradiation exposed skin. Op-AG-NE thus had potential for treatment of skin cancers and skin disorders from exposure to UVB radiation.

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Section: Resultsmentioning

confidence: 99%

“…Figure 5 a shows that the higher the equivalent concentrations of the test samples, the lower the CV of the HFF-1 cells. Since the CV of the HFF-1 cells incubated with Blank NE was more than 70% at entire equivalent concentrations (1–100 μg/mL), the Blank NE used in this study was not toxic to the HFF-1 cells [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Optimization of Production Parameters for Andrographolide-Loaded Nanoemulsion Preparation by Microfluidization and Evaluations of Its Bioactivities in Skin Cancer Cells and UVB Radiation-Exposed Skin

et al. 2021

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“…This design enables active liposome targeting to cells in the retina. The liposome is capable of safely delivering antiviral to human retinal pigment epithelial cells with inhibitory effect against cytomegalovirus [36].…”

Section: Cell-and Tissue-targeted Antiviral Nanoparticlesmentioning

confidence: 99%

Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control

Yang

Lin

Tsai

et al. 2021

Drug Deliv. and Transl. Res.

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The COVID-19 pandemic's high mortality rate and severe socioeconomic impact serve as a reminder of the urgent need for effective countermeasures against viral pandemic threats. In particular, effective antiviral therapeutics capable of stopping infections in its tracks is critical to reducing infection fatality rate and healthcare burden. With the field of drug delivery witnessing tremendous advancement in the last two decades owing to a panoply of nanotechnology advances, the present review summarizes and expounds on the research and development of therapeutic nanoformulations against various infectious viral pathogens, including HIV, influenza, and coronaviruses. Specifically, nanotechnology advances towards improving pathogen-and host-targeted antiviral drug delivery are reviewed, and the prospect of achieving effective viral eradication, broad-spectrum antiviral effect, and resisting viral mutations are discussed. As several COVID-19 antiviral clinical trials are met with lackluster treatment efficacy, nanocarrier strategies aimed at improving drug pharmacokinetics, biodistributions, and synergism are expected to not only contribute to the current disease treatment efforts but also expand the antiviral arsenal against other emerging viral diseases.

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“…developed transferrin (Tf)‐conjugated liposomes to deliver GCV via intravitreal injection and topical instillation. After Tf receptors‐mediated endocytosis, the drug‐loaded liposomes effectively inhibited the expression of CMV glycoprotein B, serving as a promising antiviral agent in the CMV retinitis therapy . Tahara et al.…”

Section: Detailed Description Of Various Antiviral Materialsmentioning

confidence: 99%

Advances in Antiviral Material Development

Liang

Ahamed

et al. 2020

ChemPlusChem

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His current research interests include Environmental Impact Assessment, Toxicity, Waste Management, and Electrochemical applications. He has worked in various government-funded and consulting projects at NTU. He is trained in Life Cycle Assessment tools such as GaBi and SimaPro, Nanotools such as AFM, Ellipsometry, ATR-FTIR and QCMD, USEtox® 2.0-Characterization fact. Liya Ge obtained her B.Eng. in chemical engineering from Zhejiang University, China in 1999. From 1999-2002, she worked as an Engineer in State Oceanic Administration, China. She subsequently completed her PhD study in analytical chemistry from Nanyang Technological University (NTU), Singapore in 2005. Since then, Dr. Ge has been working as a researcher and later a senior researcher in NTU. Her current research interests cover analytical chemistry including the development of sensors, biosensors and micro total analysis systems for rapid on-site detection and point-of-care diagnosis. Xiaoxu Fu is currently a PhD student at the School of Civil and Environmental Engineering at Nanyang Technological University (NTU), Singapore. He got his master degree in the same school in NTU and his bachelor degree in Shanghai Jiao Tong university in China. His scienfic research and interest is focused on conducting polymers and their application on biomedical, analytical and environmental applications. Grzegorz Lisak obtained his M.Sc. (Chem. Eng.) in physical chemistry in 2007 from Poznań University of Technology, Poland. He obtained his D.Sc. (Tech.

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Formulation development and in vitro evaluation of transferrin-conjugated liposomes as a carrier of ganciclovir targeting the retina

Cited by 41 publications

References 40 publications

Optimization of Production Parameters for Andrographolide-Loaded Nanoemulsion Preparation by Microfluidization and Evaluations of Its Bioactivities in Skin Cancer Cells and UVB Radiation-Exposed Skin

Optimization of Production Parameters for Andrographolide-Loaded Nanoemulsion Preparation by Microfluidization and Evaluations of Its Bioactivities in Skin Cancer Cells and UVB Radiation-Exposed Skin

Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control

Advances in Antiviral Material Development

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