Formulation design, statistical optimization and in vitro biological activities of nano-emulsion containing essential oil from cotton-lavender (Santolina chamaecyparissus L.)

Nanoemulsification of soybean oil using ultrasonic microreactor: Process optimization, scale-up and numbering-up in series

“…Obviously, the high heat accumulation triggered by the high ultrasonic power and long residence time accelerates the collision and aggregation of emulsion droplets. In addition, the polar groups of nonionic surfactants were dehydrated at high temperatures, and the nonionic surfactants without amphiphilic properties were separated from nanoemulsions, resulting in the severe aggregation of oil droplets [41] .…”

Development of Chincho (Tagetes elliptica Sm.) Essential Oil Organogel Nanoparticles through Ionic Gelation and Process Optimization with Box–Behnken Design

“…To optimize all factors and variables that can affect ionic gelation microencapsulation, the applied experimental designs can be programmed utilizing the Response Surface Methodology (RSM) and the Box–Behnken Design (BBD). RSM is an excellent tool that is very useful for detecting the influence of different formulation factors on response variables [ 39 , 40 ], while BBD is applied to establish the optimal experimental conditions, with optimal polynomial equations for the evaluated response variables [ 41 , 42 ].…”