Formulation, Characterization, and Determination of the Diffusion Rate Study of Antioxidant Serum Containing Astaxanthin Nanoemulsion

Nurdianti, Lusi; CLARA, RISNA; Suhendy, Hendy; Setiawan, Fajar; Idacahyati, Keni

doi:10.22159/ijap.2021.v13s4.43859

Cited by 2 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The test results show that the radiance dispersion of serum is in the range of 4.57-5.13 cm and this meets the requirements of the required value of 5-7 cm [21]. The value of dispersion is strongly influenced by the value of viscosity, where preparations that have a low viscosity value will have greater dispersion and vice versa.…”

Section: Discussionmentioning

confidence: 65%

“…The results of the radiance evaluation of zeaxanthin nanoemulsion serum seen from organoleptic tests include color, odor and form in the form of a transparent yellow liquid preparation that is odorless so that from an aesthetic point of view, it is very attractive to be produced on an industrial scale. Likewise, from the results of homogeneity to see the mixing of solid materials that are combined so that it becomes a homogeneous mixture with no microscopic fine solid particles visible [21].…”

Section: Discussionmentioning

confidence: 99%

“…The pH test is carried out of knowing the level of acidity or alkalinity of a preparation, where if the preparation is too acidic it will cause irritation to the skin and will cause a burning sensation on the skin so the pH of the preparation is expected to be in accordance with the pH of the skin, which is in the range of 4-7 [21].…”

Section: Discussionmentioning

confidence: 99%

“…Organoleptic testing was carried out by visually observing the radiance of the zeaxanthin nanoemulsion serum produced, including color, odor, clarity. Then the pH test of the serum radiance was carried out by measuring the pH using a calibrated pH meter [21].…”

Section: Organoleptic and Ph Testmentioning

confidence: 99%

See 3 more Smart Citations

Formulation and Characterization of Zeaxanthin Nanoemulsion Radiance Serum as Antioxidant

Setiawan

Rusdiana²,

Sopyan³

et al. 2022

Int J App Pharm

Self Cite

View full text Add to dashboard Cite

Objective: This study aimed to increase the effectiveness of using zeaxanthin by developed nanoemulsion containing zeaxanthin which was then formulated into radiance serum for topical use. Methods: Nanoemulsions are made using spontaneous nano emulsification methods/techniques, which are relatively simple technologically because they rely on the right combination of selected surfactants and co-surfactants. The optimization of the formula was carried out starting from determining the oil: surfactant: co-surfactant phase ratio and concentration of zeaxanthin. Nanoemulsion characterization in the form of physical characterization includes organoleptic tests, globule size and polydispersity index, zeta potential, pH and entrapment efficiency tests. The best results from nanoemulsion were then combined into serum preparations which were then tested for evaluation of the preparations, including organoleptic, homogeneity, viscosity, pH, spreadability, and antioxidant test. Results: The results showed that the developed zeaxanthin nanoemulsion had a globule size in the range of 20-24 nm (with a normal globule size distribution curve), polydispersity index value of less than 0.3, zeta potential greater than (-20) mV and entrapment efficiency ranging from 80-85%. Conclusion: The results of the evaluation showed that the serum radiance of zeaxanthin nanoemulsion had good physical, chemical and stability properties during storage with an IC50 value of zeaxanthin less than 50 ppm.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Organoleptic and Ph Testmentioning

confidence: 99%

See 2 more Smart Citations

Formulation and Characterization of Zeaxanthin Nanoemulsion Radiance Serum as Antioxidant

Setiawan

Rusdiana²,

Sopyan³

et al. 2022

Int J App Pharm

Self Cite

View full text Add to dashboard Cite

show abstract

Physical and Chemical Evaluations of Topical Radiance Serum Containing Nanoemulsion Combination of Astaxanthin and Zeaxanthin: Designed as Anti-Wrinkle and Skin-Brightening Serum

NURDIANTI,

SETIAWAN,

RUSDIANA

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

Objective: The present study was conducted to formulate and evaluate the radiance serum containing the combination of astaxanthin and zeaxanthin nanoemulsion designed for anti-wrinkle and skin brightening serum by topical route of administration. Methods: The nanoemulsion containing astaxanthin and zeaxanthin was prepared using the self-nano emulsifying method, followed by incorporation into the radiance serum by the conventional mixing method. The quantity and ratio of surfactant, co-surfactant, and oil phase have been optimized in the previous study, as well as the radiance serum formula. The evaluation of the nanoemulsion and radiance serum was carried out by physical and chemical characterization. At the end of the study, an antioxidant activity of the serum containing nanoemulsion of astaxanthin and zeaxanthin was performed by DPPH method and the antioxidant activity was compared to its pure forms. The evaluation of the ex vivo permeation study was carried out to evaluate its possibility as an anti-wrinkle and skin brightener. Results: An astaxanthin and zeaxanthin nanoemulsion had a good physical properties with a globule size around of 20 nm (narrow particle size distribution), an entrapment efficiency range greater than 85%, and had a spherical morphology. The radiance serum had a good organoleptic and spreadability with the semifluid characteristic. Based on the result of antioxidant activity, the radiance serum had a highly active antioxidant activity. The radiance serum contained of astaxanthin and zeaxanthin nanoemulsion of 1% concentration, astaxanthin had a 2-6 times cumulative released compared than zeaxanthin (p<0.05) and all of the formulations exhibited a high skin permeation significantly. Conclusion: A formulation of nanoemulsion-based serum containing astaxanthin and zeaxanthin for topical delivery has been successfully developed. Based on the results of physical evaluation and especially from the permeation study, it seems that radiance serum containing astaxanthin and zeaxanthin nanoemulsion was potential to be used as an anti-wrinkle and skin brightening, however this function must be proven in further research.

show abstract

Formulation, Characterization, and Determination of the Diffusion Rate Study of Antioxidant Serum Containing Astaxanthin Nanoemulsion

Cited by 2 publications

References 18 publications

Formulation and Characterization of Zeaxanthin Nanoemulsion Radiance Serum as Antioxidant

Formulation and Characterization of Zeaxanthin Nanoemulsion Radiance Serum as Antioxidant

Physical and Chemical Evaluations of Topical Radiance Serum Containing Nanoemulsion Combination of Astaxanthin and Zeaxanthin: Designed as Anti-Wrinkle and Skin-Brightening Serum

Contact Info

Product

Resources

About