Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin

Abstract

The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy.

Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles

“…The absorbance was recorded using an ELISA reader at 570 nm. This colorimetric assay focused on the reduction of MTT to purple formazan by the mitochondrial enzymes of the metabolically active cancer cells 64 . The IC 50 was calculated from the concentration of drug that inhibits 50% of cell growth.…”

Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity

“…Sodium alginate has been commonly used as an anionic polysaccharide due to its physicochemical, biocompatibility, and nontoxicity properties. Also, nanoparticle formulations containing alginate, which are known as bioactive agents, are suitable as a functional system in pharmaceutical properties [ 58 ]. Research has demonstrated that sodium alginate improved the selectivity of therapeutic agents release such as paclitaxel or doxorubicin in a certain area with enhancing safety.…”

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

“…Parenteral [194] Arabic gum Curcumin Parenteral [182] Hyaluronic acid-folic acid Oxaliplatin Oral [184] Artemisia ciniformis extract Paclitaxel Parenteral [181] Catechol Garcinia mangostana L. extract Parenteral [183] Gold nanoparticles Cisplatin Parenteral [195] Graphene oxide nanoplatelets Doxorubicin Parenteral [196] Iron oxide nanoparticles Doxorubicin Parenteral [198] Polyelectrolyte complexation Chitosan Doxorubicin Parenteral [186] Doxorubicin-paclitaxel Pulmonal [188] Cysteamine-disulphide-poly(allylamine hydrochloride) -poly(4-styrenesulfonic acid-co-maleic acid) sodium salt Paclitaxel Oral [191] Hair keratin Doxorubicin hydrochloride Parenteral [192] Chitosan-iron oxide nanoparticles Curcumin Parenteral [199] Gelation method/polyelectrolyte complexation…”

“…NPs embedding curcumin were studied for their growth inhibition capacity and anticancer activity against liver, colon, lung, and breast cancer. [182] Also, catechol-functionalized alginate NPs loaded with Garcinia mangostana L. extract were explored in the treatment of bladder cancer. [183] Remarkably, the surface functionalization with catechol guaranteed both excellent mucoadhesive properties and could prolong residence on the mucous tissues compared with unmodified Alg-NPs, thereby increasing the drug therapeutic effect.…”