Formulation and stabilization of norfloxacin in liposomal preparations

Ahmad, Iqbal; Arsalan, Adeel; Ali, Syed Abid; Bano, Raheela; Munir, Iqra; Sabah, Arif

doi:10.1016/j.ejps.2016.05.017

Cited by 15 publications

(23 citation statements)

References 77 publications

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“…Another mechanism of drug stabilization is its interaction with capsule material. The interactions of drugs with mesoporous silica [4], cyclodextrins [32], liposomal phosphatidylcholine [33] and polysaccharide microparticles [34] led to their increasing photo stability. Thermal stability of drugs was enhanced by complex formation with β-cyclodexrin [26,35] and amylose [26].…”

Section: Introductionmentioning

confidence: 99%

Development of Novel Silica-Based Formulation of α-Lipoic Acid: Evaluation of Photo and Thermal Stability of the Encapsulated Drug

2020

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Powerful antioxidant α-lipoic acid (LA) is easily degraded under light and heating. This creates difficulties in its manufacture, storage and reduces efficiency and safety of the drug. The purpose of this work was to synthesize novel silica-based composites of LA and evaluate their ability to increase photo and thermal stability of the drug. It was assumed that the drug stabilization can be achieved due to LA-silica interactions. Therefore, the composites of LA with unmodified and organomodified silica matrixes were synthesized by sol-gel method at the synthesis pH below or above the pKa of the drug. The effects of silica matrix modification and the synthesis pH on the LA-silica interactions and kinetics of photo and thermal degradation of LA in the composites were studied. The nature of the interactions was revealed by FTIR spectroscopy. It was found that the rate of thermal degradation of the drug in the composites was significantly lower compared to free LA and mainly determined by the LA-silica interactions. However, photodegradation of LA in the composites under UV irradiation was either close to that for free drug or significantly more rapid. It was shown that kinetics of photodegradation was independent of the interactions and likely determined by physical properties of surface of the composite particles (porosity and reflectivity). The most promising composites for further development of novel silica-based formulations were identified.

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Section: Introductionmentioning

confidence: 99%

Development of Novel Silica-Based Formulation of α-Lipoic Acid: Evaluation of Photo and Thermal Stability of the Encapsulated Drug

2020

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“…Also, in preparation methods like microfluidization, the use of high pressures or high shear forces during liposome synthesis, cause harmful effects on the structure of the product (Douer 2016. So, to overcome these kinds of obstacles, it would be better to apply substitute preparation methods like heating method which does not use potentially toxic solvents (Ahmad et al 2016, Kurd et al 2016, Meisel and Gokel 2016. This method is explained in the following steps:…”

Section: Heating Methodsmentioning

confidence: 99%

“…Although, light scattering methods regarding to ability to measure the size of large number of vesicles in an aqueous phase and statistically expressive analysis of size distribution of the lipid vesicles, are more fitting than microscopic techniques. To create an encyclopedic and dependable characterization of the liposomal formulations, these two procedures should be used accompanied by other low-cost and usual laboratory methods like gel permeation chromatography (Ahmad et al 2016). As an advantage of light scattering method, it provides accumulative average information of the size of a large number of nanoliposomes concurrently and as a disadvantage it does not create info on the figure of the lipidic system and it presumes any accumulation of more than one vesicle as one solitary particle.…”

Section: Size Designation Techniquesmentioning

confidence: 99%

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Panahi

Farshbaf

Mohammadhosseini

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

192

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Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability; accompanied by their nanosize they have potential applications in nanomedicine, cosmetics, and food industry. Nanoliposome technology offers thrilling chances for food technologists in fields including encapsulation and controlled release of food ingredients, also improved bioavailability and stability of sensitive materials. Amid numerous brilliant new drug and gene delivery systems, liposomes provide an advanced technology to carry active molecules to the specific site of action, and now days, various formulations are in clinical use. In this paper, we provide review of the main physicochemical properties of liposomes, current methods of the manufacturing and introduce some of their usage in food nanotechnology as carrier vehicles of nutrients, enzymes, and food antimicrobials and their applications as drug carriers and gene delivery agents in biomedicine.

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“…Previous studies have shown evidences of NOR interaction with the lipid phase of model membranes, such as protection of NOR photodegradation when encapsulated in liposomes [8] or the increase in membrane fluidity in the presence of NOR [32]. However, the partition coefficient of NOR is low (0.46) [33], probably given by its amphoteric behavior at physiologic pH.…”

Section: Discussionmentioning

confidence: 99%

“…The incorporation of the antibiotic molecule in the vesicle may occur in the lipid bilayer and/or in its inner aqueous compartment, so that the drug gets protected from degradation, prolongs its release kinetics and produces less side effects [6]. Several classes of antibiotics have been successfully encapsulated in liposomes (LIP) for multiapplication [7], including NOR, pefloxacin and ofloxacin [8,9].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains

et al. 2020

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This work describes the development of a gastroresistant antimicrobial formulation composed of two carriers, pectin and liposomes, intended to improve the efficiency of norfloxacin (NOR) against multi-resistant bacterial strains. The formulations showed physicochemical stability for 180 days (4 °C) in terms of size, polydispersity, and zeta potential of the vesicles, prolonging the in vitro release of NOR for 11 h. The hybrid nanocarriers improved the in vitro antimicrobial activity against different multidrug-resistant bacterial strains, such as Salmonella sp., Pseudomonasaeruginosa, E. coli and Campylobacterjejuni, in comparison to commercial NOR and liposomal suspensions. The in vivo toxicity assay in chicken embryos revealed that the hybrid systems were not toxic in any of the different parameters analyzed, a result also corroborated by the analyses of biochemical biomarkers of the chicken-embryos liver function.

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Formulation and stabilization of norfloxacin in liposomal preparations

Cited by 15 publications

References 77 publications

Development of Novel Silica-Based Formulation of α-Lipoic Acid: Evaluation of Photo and Thermal Stability of the Encapsulated Drug

Development of Novel Silica-Based Formulation of α-Lipoic Acid: Evaluation of Photo and Thermal Stability of the Encapsulated Drug

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains

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