Formulation and Optimization of Gastric Bioadhesive Tablets of Diltiazem Hydrochloride using Central Composite Design

Sharma, Saurabh; Nanda, Arun; Singh, Lalit

doi:10.4314/tjpr.v12i6.1

Cited by 5 publications

(2 citation statements)

References 16 publications

(20 reference statements)

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“…This problem can be resolved by making the floating system that adheres to the wall of the stomach when the fluid level depletes. The use of synthetic polymers such as carbopol, polymethacrylic acid, polyacrylic acid [7,8] and natural polymers such as xanthan gum and guar gum [9] as bioadhesive agents in the floating matrix tablets is reported in literatures.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Mali

2016

AJP

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Aim: The present investigation deals with the formulation of floating-bioadhesive matrix tablets of verapamil hydrochloride (VH). The main objective of this work was to overcome the limitations of the conventional floating matrix tablets. Materials and Methods: Hydroxypropyl methylcellulose (HPMC) K15M was used as a matrixforming agent whereas carboxymethyl tamarind gum (CMTG) was used to promote bioadhesion. Systematic optimization was performed using a central composite design with two independent variables and six dependent variables. Tablets were prepared by using the wet granulation method. The effect of polymer ratio (HPMC:CMTG) and sodium bicarbonate (SB) concentration on the total floating time (TFT), floating lag time (FLT), bioadhesion, swelling, and drug release (DR) was studied and optimized. Results and Discussion: Floating-bioadhesive matrix tablets of VH showed good physicochemical properties. The FLT was within the range of 2.87-14.41 min and TFT was more than 12 h. The tablets showed 17-30% of burst release in the 1 st h and controlled release over a period of 12-h. DR and swelling were significantly (P < 0.05) affected by polymer ratio and concentration of SB in formulation. The polynomial mathematical models, generated for various response variables using multiple regression analysis, were found to be statistically significant (P < 0.05). Optimized batch showed FLT of 6.14 min, bioadhesion of 17.23 g, swelling of 74.83% at 5 h, and DR of 75.48% at 10 h, with anomalous release mechanism. The observed values were near to the predicted values obtained by the experimental design. Conclusion: The floating-bioadhesive tablets of VH prepared using HPMC and CMTG exhibited a potential to retain and control the release of drug in stomach for more than 12 h and may be used as an alternative to the conventional floating tablets of VH.

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Section: Introductionmentioning

confidence: 99%

Untitled

Mali

2016

AJP

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“…It is a highly soluble, highly permeable drug with extensive and highly variable hepatic first pass metabolism following oral administration. The development of sustained release formulation of Diltiazem hydrochloride is therefore therapeutic relevance and can be used to provide a consistent dosage through sustaining an appropriate level of the drug over time [1][2]. Hydrophilic polymer matrix systems are widely used in oral sustained drug delivery because of their flexibility to obtain a desirable drug release profile, cost effectiveness, and broad regulatory acceptance.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Sustained Release Drug Delivery of Diltiazem Hydrochloride.

Deshmukh¹,

Shete²,

Deshmukh³

et al. 2016

JCPR

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Matrix tablets using PEC as matrix and Diltiazem HCl as a model drug were formulated by wet granulation technique. The matrix tablets were evaluated for physical properties, in vitro release and release data analysis The maximal yield was obtained when the ratio of guar gum: pectin was 3:7 (w/w).Release kinetic was evaluated by using USP XXIV dissolution apparatus type II was 89.54 %. It was concluded from the study that guar-pectin binary polymeric matrix system is an interesting alternative for preparing sustained release tablets.

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Fabrication of Famotidine Loaded Sepiolite/Pectin Bionanocomposite Hydrogels for Controlled Drug Delivery

Yasin,

Ahmad,

Imran

2024

ChemistrySelect

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Development of drug delivery systems is an extensively researched area in the biomedical field. In recent years, there has been an increasing interest in fabrication of biocompatible nanofibrous drug delivery systems. The present study describes the fabrication of calcium chloride‐crosslinked bionanocomposite hydrogels based on pectin for the use of gastro‐retentive delivery system. Sepiolite/famotidine/pectin nanocomposite hydrogel was fabricated by using Ionotropic gelation process. The thermal, structural and morphological properties were evaluated via different experimental techniques such as TGA‐DSC, FTIR, and SEM. The prepared hydrogels showed a pH sensitive swelling profile with maximum water absorption at pH 1.2. Analysis of in‐vitro drug release data revealed that the sepiolite/famotidine/pectin nanocomposite hydrogels exhibited a slight initial burst release, followed by a sustained release over a 24 h period. This was observed both in simulated gastric fluid and in phosphate‐buffered saline, suggesting that these hydrogels are well‐suited for prolonged drug delivery. To investigate the drug release kinetics, various models were applied. The release of famotidine was predominantly governed by diffusion, as described by the Korsmeyer‐Peppas model.

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Formulation and Optimization of Gastric Bioadhesive Tablets of Diltiazem Hydrochloride using Central Composite Design

Cited by 5 publications

References 16 publications

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Preparation and Evaluation of Sustained Release Drug Delivery of Diltiazem Hydrochloride.

Fabrication of Famotidine Loaded Sepiolite/Pectin Bionanocomposite Hydrogels for Controlled Drug Delivery

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