The purpose of this investigation was to design and develop trilayer matrix tablets of Nelfinavir prepared by
direct compression method and consisted of middle active layer with different grades of hydroxypropyl
methylcellulose (HPMC), PVK K 30 and MCC. Barrier layers are prepared with Polyox WSR 303, Xanthan gum,
microcrystalline cellulose and magnesium stearate. Based on the evaluation parameters, drug dissolution profile
and release drug kinetics DF8 was found to be optimized formulation. The developed drug delivery system
provided prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation
(DF8) was described by the Zero-order and best fitted to Higuchi model. From in vivo bioavailability studies the
extended release of Nelfinavir from trilayer matrix tablets also provides for higher plasma drug content and
improved bioavailability. The results indicate that the approach used could lead to a successful development of
low biological half life Nelfinavir with controlled drug release in the effective management of AIDS.