Formulation and investigation of crushed puffed rice-chitosan-HPMC based polymeric blends as carrier for sustained stomach specific drug delivery of piroxicam using 3(2) Taguchi mathematical design studies

Abstract

In the present experimental investigation an attempt has been made to assess the utility of Crushed Puffed Rice (CPR)-High Molecular Weight Chitosan (HMWCH)-Hydroxypropyl Methylcellulose K15M (HPMC K15M) as a polymeric carrier for the sustained stomach delivery of Piroxicam (PRX). A total of nine formulations were prepared by using 3 (2) Taguchi factorial design, physically blending drug and polymer(s) followed by encapsulation into hard gelatin capsules size 1. The prepared capsules were evaluated for various performance such as weight variation, drug contents, in vitro buoyancy and drug release in 0.1 M HCl. The effect of drug loading on in vitro performance of the formulations was also determined. Crushed puffed rice (CPR) remained buoyant for up to average time span of 06 hr as an unwetted irregular mass in 0.1 M HCl. However, when combined with HMWCH or HPMC K15M or HPMC K15M + HMWCH a low -density cylindrical raft type hydrogel was formed which remained buoyant for up to 12 hr and released up to 99% drug in a sustained manner from 8 to 12 hr following zero order release kinetics. It was also observed that drug release from drug + CPR matrices followed Fickian mechanism. Combination of CPR + HMWCH or HMWCH + HPMC K15M also follows Fickian mechanism. Obtained data from the research work suggests that CPR in combination with HMWCH or HPMC K15M or HPMC has sufficient potential to be used as a carrier for stomach specific delivery of gastric irritant drug like PRX.Soni et al., International Current Pharmaceutical Journal, April 2018, 6(11): 61-80http://www.icpjonline.com/documents/Vol6Issue11/01.pdf

An Innovative Mucoadhesive Thermosensitive In situ Gelling Liquid Suppository of Metoclopramide Hydrocloride for Treatment of Nausea and Vomiting Associated with Diseases

“…Besides, the FT-IR spectrum of HPMC K15M was represented by stretching of alkyl C-H and phenolic O-H at 2930.54 cm -1 and 3462.75 cm -1 respectively, the absorption peak at 1317.43 cm -1 that represented stretching of C-O-ether linkage. It also shows the stretching of the alcohol C-O group at 1062.81 cm -1 [32,72] .…”

Processing, characteristics and applications of expanded grains

“…It gives a new scope to use puffed grains as a fortification medium for its affordability and wide utility (Paraman et al, 2012). Being porous in nature, puffed grains are researched for its potential to act as a matrix to deliver drugs and bio-functional compounds to the body (Soni et al, 2018). The puffed grain can also be pulverized and made into flour.…”

Puffed rice: A materialistic understanding of rice puffing and its associated changes in physicochemical and nutritional characteristics

“…Being a porous matrix, it may aid in resolving gastrointestinal disorders by being an absorbent (Kulkarni, Kunte, Sonawane, & Pandit, 2011). This porous matrix can further be considered as a delivery matrix for various drugs and bioactive compounds (Soni, Ram, & Verma, 2018) and micronutrients, thereby opening new areas of application based research. Fortified puffed rice containing micronutrients like vitamin B12 has been developed based on extrusion technology.…”