Formulation and in vivo study of the solid effervescent system as a new strategy for oral glutamine delivery

Ferrari, Bruna Juliana Wanczinski; Pelegrini, Bruna Luíza; Silva, Jéssica Bassi da; Pereira, Omar Cléo Neves; Lima, Marli Miriam de Souza; Bruschi, Marcos Luciano; Bazotte, Roberto Barbosa

doi:10.1016/j.jddst.2021.102516

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Each sachet contained 12.5 g of glutamine (Ajinomoto North America, USA), combined with 3.90 g of sodium bicarbonate as the effervescent base (Arbros Industria Pharma e Alimentícia Ltda., Brazil), as well as 1.30 g citric acid and 2.60 g of tartaric acid (SM Pharmaceutical Enterprises, Brazil), which release carbon dioxide when dissolved in water to initiate effervescence ( 32 ).…”

Section: Methodsmentioning

confidence: 99%

Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial

Nóbrega,

Silva,

Rampani

et al. 2024

Braz J Med Biol Res

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In this double-blind placebo-controlled randomized investigation, we assessed the tolerability of glutamine in older adults recruited from three daycare centers. The relevance of studying glutamine supplementation in elderly patients lies in its potential to provide a well-tolerated intervention. Glutamine, a crucial amino acid, plays a vital role in various physiological processes, including immune function and protein synthesis. Understanding its impact on older adults is essential, given the potential implications for their health and well-being. Participants received a daily dose of 12.4 g of oral effervescent glutamine (EGln group) or maltodextrin (placebo group) for 60 days. Fifteen patients from each group completed the study. The mean ages were 77.0±9.1 and 79.0±6.9 years for the EGln and placebo groups, respectively. We evaluated body mass index, aminogram, hemogram, plasma levels of glucose, prealbumin, albumin, urea, creatinine, uric acid, C-reactive protein, vitamin D, calcium, sodium, potassium, and the plasma activities of aspartate aminotransferase and alanine aminotransferase. Notably, we quantified a broad array of inflammatory markers and growth factors providing a holistic understanding of the potential effects of glutamine supplementation. The results demonstrated that oral glutamine did not induce significant changes in any evaluated parameters, and no adverse effects were reported. This finding suggested that the dosage of glutamine used in this study was well-tolerated and safe. This information contributes to the broader understanding of glutamine supplementation, emphasizing its safety and supporting its potential as a viable intervention for maintaining health in aging individuals.

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Section: Methodsmentioning

confidence: 99%

Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial

Nóbrega,

Silva,

Rampani

et al. 2024

Braz J Med Biol Res

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“…The higher solubility of the amorphous BCs is due to their higher lattice‐free energy, requiring less energy for dissolution (Babu and Nangia, 2011; Brittain et al., 2009). Reduced crystallinity has been shown to improve water solubility, bioaccessibility, and/or bioavailability of various BCs and drugs, including phytosterols (Ubeyitogullari & Ciftci, 2016b), curcumin (Ubeyitogullari & Ciftci, 2019b), glutamine (Wanczinski Ferrari et al., 2021), ketoprofen (Lovskaya & Menshutina, 2020), and gallic acid (Y. Zhang et al., 2019).…”

Section: Bioaccessibility and Bioavailabilitymentioning

confidence: 99%

Polysaccharide‐based porous biopolymers for enhanced bioaccessibility and bioavailability of bioactive food compounds: Challenges, advances, and opportunities

Ubeyitogullari

Ahmadzadeh

Kandhola

et al. 2022

Comp Rev Food Sci Food Safe

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Bioactive food compounds, such as lycopene, curcumin, phytosterols, and resveratrol, have received great attention due to their potential health benefits.However, these bioactive compounds (BCs) have poor chemical stability during processing and low bioavailability after consumption. Several delivery systems have been proposed for enhancing their stability and bioavailability. Among these methods, porous biopolymers have emerged as alternative encapsulation materials, as they have superior properties like high surface area, porosity, and tunable surface chemistry to entrap BCs. This reduces the crystallinity (especially for the lipophilic ones) and particle size, and in turn, increases solubilization and bioavailability. Also, loading BCs into the porous matrix can protect them against environmental stresses such as light, heat, oxygen, and pH. This review introduces polysaccharide-based porous biopolymers for improving the bioaccessibility/bioavailability of bioactive food compounds and discusses their recent applications in the food industry. First, bioaccessibility and bioavailability are described with a special emphasis on the factors affecting them. Then, porous biopolymer fabrication methods, including supercritical carbon dioxide

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Metabolite variations in the sera of HIV+ patients after an oral administration of effervescent glutamine and in comparison to non-HIV individuals by NMR

et al. 2023

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Formulation and in vivo study of the solid effervescent system as a new strategy for oral glutamine delivery

Cited by 5 publications

References 49 publications

Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial

Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial

Polysaccharide‐based porous biopolymers for enhanced bioaccessibility and bioavailability of bioactive food compounds: Challenges, advances, and opportunities

Metabolite variations in the sera of HIV+ patients after an oral administration of effervescent glutamine and in comparison to non-HIV individuals by NMR

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