Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate

Satpute, Mangesh Machhindranath; Tour, Nagesh Shivaji

doi:10.1590/s1984-82502013000400018

Cited by 13 publications

(12 citation statements)

References 6 publications

(6 reference statements)

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“…These results are in line with the previous study conducted by Satpute et al, SSG, CCS, and CP were in use as super disintegrants for Metoprolol orally disintegration tablets formulation. In this previous study by satpute et al, the crospovidone (6.6 %) containing formulation show a better disintegration time [18]. showed comparatively better dispersion time.…”

Section: Evaluation Parameter Of Formulated Tabletsmentioning

confidence: 77%

Formulation and Evaluation of Orally Disintegrating Tablet of Metoclopramide Hydrochloride

Dawadi

Pandey

Nepal

et al. 2020

World Journal of Current Med and Pharm Research

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Orally disintegrating drug delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the fastest, safest, convenient, and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets. The goal of this study was to formulate and evaluate oral disintegrating tablets (ODTs) of Metoclopramide hydrochloride to overcome swallowing difficulties. The key to developing successful ODT formulation by direct compression method is to select the right super disintegrant. Nine formulations were prepared using different super disintegrants such as sodium starch glycolate (SSG), croscarmellose sodium (CCS), and crospovidone (CP) at three concentrations i.e. 2.8 %, 4 %, and 4.8 %. The formulation was evaluate for pre and post-compression parameters like angle of repose, compressibility index, Hausner's ratio, uniformity of content, thickness, hardness, friability, drug content, wetting time, water absorption ratio, dispersion time, in-vitro disintegration time etc. Results revealed that among the 9 formulations, the formulation MHF9 containing 4.8 % of crospovidone was selected as the best formulation as its wetting time 28 second, disintegration and dispersion time 7 second and 18 seconds, percentage drug release after 15 minutes was 102.52 %.

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Section: Evaluation Parameter Of Formulated Tabletsmentioning

confidence: 77%

Formulation and Evaluation of Orally Disintegrating Tablet of Metoclopramide Hydrochloride

Dawadi

Pandey

Nepal

et al. 2020

World Journal of Current Med and Pharm Research

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“…for tablets produced at different compression forces, respectively. The Carr's Index and the Hausner ratio are the indication of powder or granule flowability relevant to compressibility 2,3 . According to the Carr's Index (Table 1), granules of mesh 14, 30 and 40 having excellent flowability, whereas granules of mesh 18 and 60 contain good and fair flowability, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…corresponds to the mesh screen size of a sieve, and the powder or granule flow ability and compressibility, can be measured by using the Carr's Index that is evaluated by the ratio of the difference between the tapped bulk density and the aerated bulk density to the tapped bulk density 2 . It can also be measured by using Hausner ratio which evaluated by the ratio of the tapped bulk density to the aerated bulk density 3 .…”

mentioning

confidence: 99%

Untitled

2014

IJPSR

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By using five different sieve sizes of ascorbic acid granules, affects of granule sizes on tablet properties, i.e. tablet weight and hardness have been studied with standard methods. Affects of lubricant types and concentrations on tablet properties, i.e. tablet hardness and disintegration time have also been studied by using magnesium stearate and sodium stearyl fumarate as the lubricants for producing tablets from mixed sizes granules of ascorbic acid. Moreover, affects of high, moderate or medium and low compression forces on tablet hardness and disintegration time have been studied by using the mixed sizes granules of ascorbic acid. The result reveals that medium sized granules are better than smaller or larger granules to produce tablets within the specificity. Tablet weight variation has been found as higher during the production of tablets from smaller or larger granules. Production of tablets without lubricants has been complicated due to the difficulties in tablet ejection, resulting in picking, sticking, capping and cracking of tablets, higher tablet hardness and lower disintegration time. With increasing concentration of lubricants, tablet hardness has been found to be decreased, whereas disintegration time has been observed to be increased. The order of sensitivity of the granules has been found as 3% > 5% > 0.25% for magnesium stearate and 5% > 0.25 > 3% for sodium stearyl fumarate. Increased tablet hardness and disintegration time have been observed for the increase in compression forces.

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“…The prepared drug pellet was scanned between 4000 to 400 cm -1 at a resolution of 4 cm -1 . The spectrum was recorded and interpreted for the confirmation of the drug purity [11,12].…”

Section: Compatibility Studiesmentioning

confidence: 99%

Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study

Kumar¹,

Pandit²

2020

Int J Pharm Pharm Sci

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Objective: In the present investigation, fast dissolving tablets of cefpodoxime proxetil were formulated using superdisintegrants to impart fast disintegration. Methods: In the current study, 12 formulations of fast dissolving tablets of cefpodoxime proxetil were formulated using two different approaches viz., direct compression and sublimation. Three different superdisintegrants viz., croscarmellose sodium, sodium starch glycolate, and crospovidone were used in a different concentration in all the respective formulations. The final powder blend was subjected for the pre-compression evaluation and all the formulations were evaluated for post-compression parameters. Stability studies were also evaluated for the best formulations as per ICH guidelines. Finally, results were statistically analyzed by the application of one way ANOVA test and t-test. Results: Among all the formulations of different approaches, formulation cefpodoxime proxetil 4 (CP4) containing 6% crospovidone as a super disintegrant was showed the best results. In vitro dissolution data revealed that formulation CP4 prepared by direct compression method showed 99.387±0.270% drug release within 15 min whereas the percentage release by formulation prepared by using sublimation showed 83.927±0.735% release. The optimized formulation was further subjected to comparative in vitro study with two marketed formulation of different brands. Conclusion: All the data of all formulations is shows that direct compression approach is the best approach for developing the fast dissolving tablets to enhance the onset of action and bioavailability.

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Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate

Cited by 13 publications

References 6 publications

Formulation and Evaluation of Orally Disintegrating Tablet of Metoclopramide Hydrochloride

Formulation and Evaluation of Orally Disintegrating Tablet of Metoclopramide Hydrochloride

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Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study

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