Formulation and evaluation of Taste Masked Mouth Dissolving Tablet of Levocetrizine dihydrochloride by using Ion-Exchange Resin

Mishra, Rosaline; Barman, Moumita; Singh, Monika; Snigdha, Snigdha; Bhardwaj, Bhardwaj; Saxena, Prasoon Kumar; Sahu, Smriti

doi:10.21276/ijrdpl.2278-0238.2018.7(5).3104-3109

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is the active R-enantiomer of cetirizine, which is used to relieve the symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis, and chronic urticarial with no sedation. Since the effects last for 24 hours, just one dose of 5 mg film-coated tablets or oral solution (0.5 mg/mL) is indicated every day [10,11]. It was found during our investigation of this medication at Aden's private pharmacies that it is marketed by various different pharmaceutical brands and companies.…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Some Brands of Levocetirizine Dihydrochloride Film-Coated Tablets for Quality and Equivalence Sold in Aden, Yemen

Al-Kubati

Ahmed

Saif

2022

Electron. J. Univ. Aden Basic Appl. Sci.

View full text Add to dashboard Cite

Generic drugs are less expensive than innovator drugs, and their proliferation has become a problem in low-income countries. They need to be therapeutically and pharmaceutically equivalent to the innovator. Levocetirizine dihydrochloride is an effective drug for relieving the signs of chronic urticaria, perennial allergic rhinitis, and seasonal allergic rhinitis. Our investigation into this drug in private pharmacies in Aden, Yemen, revealed that it is sold under the names of 28 brands from different countries of origin. Because of this, it is difficult for medical professionals and patients who use this medication without a prescription to select a suitable, safe, and cost-effective drug product. We assessed the quality and equivalency of six different brands of levocetirizine dihydrochloride film-coated tablets and assigned codes A, B, C, D, E, and F, with Brand A serving as the reference. The UV analytical method was evaluated for quantifying the drug from the tablets. The results indicated that it was accurate and precise. The tablets were evaluated for weight variation, thickness, hardness, friability, drug content, disintegration time, and dissolution. In order to compare the drug's dissolving profiles, the difference factor (f1) and similarity factor (f2) were used. For all six brands, the physicochemical parameter results met the acceptable limits. All six brands showed evidence of dissolving within 15 minutes, with values ranging from 80.05 ±0.81 to 103.83 ±0.90 which were within the recommended value of 80% within 30 minutes for oral solid dosage forms intended for immediate release. According to the f1 and f2 results, only brands B, D, and E were comparable to brand A and could be used interchangeably. In conclusion, four of the six brands are interchangeable. For high-quality public health, a thorough analysis and ongoing monitoring are needed to ascertain the quality and equivalency of the medications marketed under various brands.

show abstract

Section: Introductionmentioning

confidence: 99%

The Evaluation of Some Brands of Levocetirizine Dihydrochloride Film-Coated Tablets for Quality and Equivalence Sold in Aden, Yemen

Al-Kubati

Ahmed

Saif

2022

Electron. J. Univ. Aden Basic Appl. Sci.

View full text Add to dashboard Cite

show abstract

Formulation Optimization and Evaluation of Taste Masked Oro-dispersible Tablet of Levocetrizine Dihydrochloride by Ion Exchange Resin

P¹,

Ashwini²,

Bari³

et al. 2022

RJPDFT

View full text Add to dashboard Cite

The aim of this study was to prepare ODT of taste masked levocetrizine dihydrochloride by using ion exchange resin. Levocetrizine Dihydrochloride is bitter in taste, Kyron T-134 a weak cationic exchange resin was used to mask the bitter taste of the drug. The ODTs were prepared by using drug-resin (DRC) complex using batch process. Compression of ODTs was done by using direct compression method with the technique of addition of superdisintegrants. Central composite design (CCD) was applied as an optimization technique. FTIR and DSC studies indicated drug and excipients were compatible with each other. The prepared orodispersible tablet blend and tablets were evaluated for various pre-compression and post-compression parameters. The Batch LH3 was given as optimized batch by central composite design. This optimized batch LH3 was passed all the pre-compression and post- compression parameters. The prepared ODTS showed successfully rapid onset of action with decrease in disintegration time 26 sec and %drug released was found to be 98.26%. It was concluded that levocetrizine dihydrochloride ODTs were prepared successfully by taste masking method using Kyron T-134 ion exchange resin and croscarmellose sodium as Superdisintegrant using CCD. AS per CDER guidelines, it shows DT within 5-30 sec.

show abstract

Formulation and evaluation of Taste Masked Mouth Dissolving Tablet of Levocetrizine dihydrochloride by using Ion-Exchange Resin

Cited by 2 publications

References 0 publications

The Evaluation of Some Brands of Levocetirizine Dihydrochloride Film-Coated Tablets for Quality and Equivalence Sold in Aden, Yemen

The Evaluation of Some Brands of Levocetirizine Dihydrochloride Film-Coated Tablets for Quality and Equivalence Sold in Aden, Yemen

Formulation Optimization and Evaluation of Taste Masked Oro-dispersible Tablet of Levocetrizine Dihydrochloride by Ion Exchange Resin

Contact Info

Product

Resources

About