Formulation and Evaluation of Orodispersible Tablet of Domperidone

Ma, Islam; Haider, Syed Shabbir; Reza, Selim

doi:10.3329/dujps.v10i2.11791

Cited by 5 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The three formulations containing Cop–CM and low strength drugs (montelukast and domperidone) were investigated. Different reported ODT formulations for these two drugs using almost DC technique are summarized in Table 4 [ 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. In these formulations, several excipients were used to obtain fast disintegrating tablets.…”

Section: Resultsmentioning

confidence: 99%

Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets

et al. 2015

View full text Add to dashboard Cite

This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop–CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll compaction (RC). Differential scanning calorimetry (DSC), Fourier transform-Infrared (FT-IR), X-ray powder diffraction (XRPD) and scanning electron microscope (SEM) techniques were used to characterize Cop–CM, in addition to characterization of its powder and ODT dosage form. The effect of particle size distribution of Cop–CM was investigated and found to have no significant influence on the overall tablet physical properties. The compressibility parameter (a) for Cop–CM was calculated from a Kawakita plot and found to be higher (0.661) than that of mannitol (0.576) due to the presence of the highly compressible chitin (0.818). Montelukast sodium and domperidone ODTs produced, using Cop–CM, displayed excellent physicochemical properties. The exceptional binding, fast wetting and superdisintegration properties of Cop–CM, in comparison with commercially available co-processed ODT excipients, results in a unique multifunctional base which can successfully be used in the formulation of oro-dispersible and fast immediate release tablets.

show abstract

Section: Resultsmentioning

confidence: 99%

Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The time interval between evaluations of each test formulation in the same volunteer was 30 min, at after evaluated each formulation, one half of a bread slice was given to each volunteer followed by half glass of water and cocoa powder for neutralizing the taste buds. After completion of the study, data was compiled and evaluated the formulations and allotted the rank for all formulation, based on the average value of the each formulation 29 .…”

Section: Taste Evaluationmentioning

confidence: 99%

Formulation and Evaluation of Taste Masked Orodispersible Tablets of Amlodipine Besylate by Direct Compression

Prasad¹,

Gupta²,

Devanna³

et al. 2013

Int. Res. J. Pharm.

View full text Add to dashboard Cite

The purpose of this investigation was undertaken to design a simple, rapid, cost effective and highly efficient process to fabricate intensely bitter taste of Amlodipine Besylate by complexing drug with Aminoalkyl methacrylate copolymer (Eudragit EPO) in different ratios by Hot-Melt Extrusion method. Taste masked complex were analyzed with FTIR, DSC and XRD. DCP were tested for Hardness, Thickness, Weight Variation, Drug Content, Water absorption and In vitro Dispersion Test in Simulated Salivary Fluid pH 6.8. Taste masked granules were directly compressed into tablets using Kollodion CL and Croscarmellose Sodium (Ac-Di-Sol) as superdisintegrants. Tablets of batch F6 containing mannitol and 6% wt/wt of Kollodion CL showed faster disintegration with in 24 sec and drug release (t90, 180sec) at Phosphate Buffer pH 6.8. The observed polymer interaction and reduced crystallinity may be reason for increased dissolution rate. Thus results conclusively demonstrate successful masking of taste, disintegration and dissolution of the formulated tablets.

show abstract

“…Its low water solubility is the reason of the low bioavailability. [ 13 14 ] To increase the dissolution rate of this drug, some techniques have been used such as melt granulation technique,[ 15 ] orodispersible tablet,[ 16 ] solid lipid nanoparticles,[ 17 ] self-microemulsifying systems,[ 18 ] inclusion complex with cyclodextrins,[ 19 ] and solid dispersion[ 14 ] technique.…”

Section: Introductionmentioning

confidence: 99%

Solubility Enhancement of Domperidone by Solvent Change In situ Micronization Technique

Enteshari

Varshosaz

2018

Adv Biomed Res

View full text Add to dashboard Cite

Background:Domperidone (DOM), a dopamine receptor antagonist, is used as antiemetic for the treatment of gastroparesis, vomiting, and nausea. The low water solubility of DOM leads to a low dissolution rate and variable bioavailability. The aim of this study was to enhance the solubility of DOM by the preparation of micron-sized particles.Materials and Methods:The in situ micronization process was carried out using solvent change method in the presence of Soluplus® or PEG6000 as stabilizing agents. DOM was dissolved in appropriate solvent (acetone and methanol 1:1 v/v), and the stabilizing agent was dissolved in water (as nonsolvent). The nonsolvent was poured rapidly into the drug solution under stirring by a homogenizer, and the resultant was freeze dried. The crystalline shape and particle size of DOM and interaction of DOM with stabilizers were investigated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC), and then, dissolution test was carried out.Results:Optimum formulation was composed of DOM (0.5%) and PEG6000 (0.1%) with the lowest particle size (3 μm) and the highest DE60% (95.95%) as compared to pure DOM (particle size of 13.4 μm and DE60% 52.18%).Conclusion:SEM micrographs showed uniform and spherical shape of microcrystals. FTIR, XRD, and DSC studies indicated the micron size of the microcrystals and no interference between the drug and the stabilizer.

show abstract

Formulation and Evaluation of Orodispersible Tablet of Domperidone

Cited by 5 publications

References 7 publications

Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets

Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets

Formulation and Evaluation of Taste Masked Orodispersible Tablets of Amlodipine Besylate by Direct Compression

Solubility Enhancement of Domperidone by Solvent Change In situ Micronization Technique

Contact Info

Product

Resources

About