Formulation and evaluation of miglitol matrix tablets by using Hibiscus rosa sinensis leaves mucilage

Deepika, B; Sujatha, K.; Thirupathi, Anand; Chamundeeswari, D.

doi:10.5958/0974-360x.2021.00043.3

Cited by 1 publication

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“…The mucilage was separated, dried in an oven at a temperature less than 50°C, collected, dried, powdered, passed through sieve no. 80, and stored for further use in desiccator [10,11].…”

Section: Extraction Of Hibiscus Rosa Sinensis Leaf Mucilagementioning

confidence: 99%

Formulation and Evaluation of Ciprofloxacin Hydrochloride Sustained Release Tablets Using Hibiscus Rosa Sinensis Mucilage

Sahu¹,

Chouksey²,

Ganju³

2022

JASR

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Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Delivery systems extended release or controlled release rate can achieve predictable and reproducible, the extended duration of activity for the short time of life - drugs, reduced toxicity, and dose reduction request, the optimized therapy and better patient compliance. It is controlled primarily by the type and the proportion of the polymers used in the preparation. Ciprofloxacin hydrochloride is an extremely potent antibacterial agent with potent activity against most gram +ve and gram -ve bacteria. The objective of present work was to develop and evaluated oral sustained release matrix tablet of ciprofloxacin hydrochloride prepared by the method of wet granulation, using hydroxy propyl methyl cellulose (HPMC) and hibiscus rosa sinensis mucilage polymer alone and in combination at various concentrations. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight, friability and In vitro release studies. No interactions were observed between ciprofloxacin hydrochloride and excipients from the Fourier transform infrared spectroscopy. The quantity of ciprofloxacin hydrochloride present in the tablets and the release medium were estimated by a simple, rapid and validated UV method. The swelling of the mixture of polymers was higher than that of any of the individual polymer containing formulations. The swelling index ranged from 51-211 % at the end of 10 h of study. It was observed that of all the formulations F1 and F4 could not sustain the release of ciprofloxacin up to 10 h. All other formulations were able to sustain the release of ciprofloxacin for 24 h duration. The formulations F5 and F7 exhibited almost similar release profiles with 64.96 and 67.18% drug release at 24 h. The results obtained from the study conclusively indicate that use of HPMC and hibiscus rosa sinensis leaf mucilage as the matrix forming substance could help in achieving sustained release over a longer duration and help in reducing the dose as well as frequency of administration of the medicaments.

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“…The mucilage was separated, dried in an oven at a temperature less than 50°C, collected, dried, powdered, passed through sieve no. 80, and stored for further use in desiccator [10,11].…”

Section: Extraction Of Hibiscus Rosa Sinensis Leaf Mucilagementioning

confidence: 99%