Evaluation of wound healing activity of polyherbal and Euphorbia hirta formulations was done. The study aimed at preparing a polyherbal formulation containing equal proportions of ethanolic extract of Tridax procumbens, Euphorbia hirta, Eclipta alba, dried rhizome of Curcuma longa and gel of Aloe barbadensis. Excision wound, incision wound and granulaoma wound models were studied. In excision wound model it was observed that 100% wound healing was found on 12th day of the experiment on application of 10% polyherbal ointment and 100% wound contraction was found on 16th day of application of 10% ointment of E. hirta. The results were statistically compared with control and found significant. Similarly, period of epithelilization, biochemical parameters and weight of granuloma tissues showed better results in the treated groups when compared with control in the studied wound models. Thus it is concluded that topical and oral formulations were found to contain significant wound healing activity.
The main objective is to study the importance of liposome in drug targeting in cancer cells andgo through various research work going through on liposome. The importance of liposomes to study the flexibility to couple with the specific ligands toachieve active targeting. Cancer can be treated by surgery, radiation, chemotherapy, gene therapy, immunotherapy, hormone therapy. Cancer is the uncontrolled growth of abnormal cell anywhere in a body. The abnormal cells aretermed cancer cells, malignant cells, or tumor cells. There were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer (within 5 years of diagnosis) in 2018 worldwide. 57% (8 million) of new cancer cases, 65% (5.3 million) of the cancer deaths and 48% (15.6 million) of the 5-year prevalent cancer cases occurred in the less developed regions.
Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Delivery systems extended release or controlled release rate can achieve predictable and reproducible, the extended duration of activity for the short time of life - drugs, reduced toxicity, and dose reduction request, the optimized therapy and better patient compliance. It is controlled primarily by the type and the proportion of the polymers used in the preparation. Ciprofloxacin hydrochloride is an extremely potent antibacterial agent with potent activity against most gram +ve and gram -ve bacteria. The objective of present work was to develop and evaluated oral sustained release matrix tablet of ciprofloxacin hydrochloride prepared by the method of wet granulation, using hydroxy propyl methyl cellulose (HPMC) and hibiscus rosa sinensis mucilage polymer alone and in combination at various concentrations. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight, friability and In vitro release studies. No interactions were observed between ciprofloxacin hydrochloride and excipients from the Fourier transform infrared spectroscopy. The quantity of ciprofloxacin hydrochloride present in the tablets and the release medium were estimated by a simple, rapid and validated UV method. The swelling of the mixture of polymers was higher than that of any of the individual polymer containing formulations. The swelling index ranged from 51-211 % at the end of 10 h of study. It was observed that of all the formulations F1 and F4 could not sustain the release of ciprofloxacin up to 10 h. All other formulations were able to sustain the release of ciprofloxacin for 24 h duration. The formulations F5 and F7 exhibited almost similar release profiles with 64.96 and 67.18% drug release at 24 h. The results obtained from the study conclusively indicate that use of HPMC and hibiscus rosa sinensis leaf mucilage as the matrix forming substance could help in achieving sustained release over a longer duration and help in reducing the dose as well as frequency of administration of the medicaments.
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