Formulation and Evaluation of Lansoprazole Loaded Nanosponges

Penjuri, Subhash Chandra Bose; Nagaraju, R.; Saritha, Damineni; Bns, Sailakshmi; Poreddy, Srikanth Reddy

doi:10.4274/tjps.2016.04

Cited by 43 publications

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“…In-vitro release of drug from enteric-coated tablet follows zero-order and showed controlled release behavior for a period of 24 h. The data obtained in this study suggest that nanosponges of lansoprazole are promising for controlled drug delivery, which can reduce dosing frequency 45 .…”

Section: Characteristics Of Drugs Suitable Formentioning

confidence: 62%

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2020

IJPSR

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The contemporary development in the drug delivery system is a seamless process. Any delivery system targeting a molecule to a particular site is always been appreciated. This requirement can be fulfilled through a specialized drug delivery system that can easily target the drug at the site of action without compromising its efficacy and quality. Few new drugs typically cannot be effectually delivered by conventional dosage form. Hence, benefits from targeted, localized delivery of therapeutic agents are other driving forces for the current scenario. Nanosponge technology has been introduced to assist the release of drug in a controlled manner over time to reduce systemic toxicity and severe reactions. Nanosponges are tiny sponges with a size of about a virus (250 nm-1 μm), which consist of cavities that can be filled with a wide variety of hydrophilic as well as hydrophobic drugs, which can be further incorporated into a pharmaceutical dosage form such as oral, parenteral, topical or inhalation. The sighting of nanosponge has become a noteworthy step in overcoming certain problems such as drug toxicity, poor bioavailability, physiochemical instability , and patient non-acceptability. INTRODUCTION: Authentic targeted drug delivery systems have been a fantasy for always in the past and today as well. But it has been mainly unsatisfied by the difficult chemistry that is involved in the new development systems. Targeting drug delivery has long been problematic for medical investigators, i.e., how to get them to the right place in the body and how to control the release of the drug to prevent overdoses.

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Section: Characteristics Of Drugs Suitable Formentioning

confidence: 62%

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2020

IJPSR

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“…The SEM web structure may be due to the pervasion of the dissolvent from the nano-sponge surface (Penjuri et al, 2016;Tejashri et al, 2013). In addition, to the crosslinking effect of (DPC) that, acted like teeny grappling clasps to join various portions of the polymer together, in order to achieve spheroidal shaped particles fraught with chambers (cavities), where the drug molecules could be hoarded (Penjuri et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The in-vitro release study on the blank and NAC loaded nano-sponge ratios was done in triplicates in phosphate buffer (pH=7.4), using a cellulose dialysis-membrane, with a cut off 12,000 Dalton, at 37±1°C under 100 rpm rotation for 288 hours continuously. Samples were withdrawn at pre-determined intervals with maintaining sink condition and analyzed spectrophotometrically (Torne et al, 2013;Penjuri et al, 2016).…”

Section: In-vitro Release Of Nac Nano-spongesmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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This study centered on the ability of the cross-linked nano-sponge system to load the drug and to improve its physicochemical and dissolution properties. A spectrophotometric method was used to determine the wavelength of maximum absorbance of the drug. The ultrasonic-assisted synthesis method was used for nano-sponge preparation. Solution-state interactions, encapsulation efficiency and production yield, and in-vitro release were also investigated. Nano-sponges were characterized by Transmission Electron-Microscopy (TEM), Scanning Electron-Microscopy (SEM), Fourier Transform-Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and X-Ray Diffractometry (X-RD) studies. The maximum absorption wavelength of N-acetyl-L-carnosine was found to be at 210 nm. Solutionstate interaction studies revealed a bathochromic shift. The production yield of nano-sponges ranged from 59.58% to 72.54%. In-vitro release study showed a sustained drug release for 228 hours. TEM images showed regular spherical shapes and sizes of nano-sponges. Their average particle size ranged from 28 nm to 79.2 nm. DSC data documented the drug-polymer interactions. FT-IR determined the presence of functional groups. X-RD showed the physicochemical characteristics of nano-sponges. Proving successful development of N-acetyl-L-carnosine polymeric nano-sponge system with a suitable drug delivery over an extended period beside a noticeable improvement in the physicochemical characterization.

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“…They have the ability to solubilize poorly soluble drugs and extend the release of drugs by increasing their bioavailability. Due to the internal hydrophobic cavity and external hydrophilic branches, both hydrophilic and lipophilic drug molecules can be loaded into the nanosponge 16 . Now, targeted drug delivery has always been a long-term problem for medical researchers.…”

Section: Nanosponges As Protective Agent Against Photomentioning

confidence: 99%

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2021

IJPSR

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Formulation and Evaluation of Lansoprazole Loaded Nanosponges

Cited by 43 publications

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