Formulation and Evaluation of Ketoconazole Polymeric Films for Topical Application

Abstract

The objective of the current paper was to prepare and evaluate various polymeric films for fungal infection treatment and its impact on volunteer patients. Different Eudragit polymeric films containing Ketoconazole as antifungal drug were prepared by solvent casting technique. The prepared films were tested for their physicomechanical properties as tensile strength, physical endurance, elasticity, water vapor permeation and water loss. The release of ketoconazole from the prepared medicated films was examined. It is involved 20 volunteers suffering from legs fungal infection. Ten of the patients used the films and a follow up study was carried out for 14 days, in comparison with other patients who applied ketoconazole medicated ointment, cream gel and Emulgel. The results revealed that films prepared with Eudragit RL 100 containing glyceryl triacetate produced maximum release of ketoconazole both In vitro and In vivo as compared with other topical dosage forms as ointment, cream, gel and Emulgel. Moreover, the films constitute a simple and convenient method for treatment of various fungal infections. As conclusion, the use of antifungal drugs such as Ketoconazole incorporated in polymeric films, the output results provided promised evidence in the treatment of dermatophytosis.

Design, Development and in Vitro Characterization of Emulgels Loaded with Fluconazole Solid Dispersion and Various Oils for Synergestic Anti-Fungal Effect

“…The viscosity of various formulation is done with the spindle PF in different shear rate (2,5,10,15,20,25) and approx. all the formulation have good viscosity which is decreasing with respect to increasing of shear rate.…”

Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs

“…Serving as a local (isolated) drug depot and providing a mechanism for controlled release, such systems can deliver high topical concentrations of drugs without pronounced systemic spread [54]. Thus, systems such as polymeric films [55], nano- and microemulsions [56], vesicular carriers [57] (including liposomes [58], ethosomes [59], transethosomes [60], and niosomes [61]), solid lipid [62] and polymeric particles [63], and porous inorganic carriers [64, 65] were proposed and investigated for antifungal agents’ penetration promotion.…”