Formulation and Evaluation of Ibuprofen Controlled Release Matrix Tablets Using Its Solid Dispersion

Abstract

Objective: The aim of the present work was to prepare solid dispersion of ibuprofen with PEG 6000 to increase the aqueous solubility of the drug and to develop the solid dispersed ibuprofen into tablet formulation with the combination of a hydrophilic and hydrophobic polymer to attain controlled release of ibuprofen.
 Methods: Solid dispersion of ibuprofen was prepared by melting-solvent method by varying the ratio of drug and PEG 6000. The solid dispersed ibuprofen was subjected to tablet formulation by using a hydrophilic swellable polymer-carbopol and hydrophobic non-swellable polymer-ethyl cellulose. The release of the drug from the polymer matrix was studied as the polymer ratio changes.
 Results: Compatibility between drug and polymers was established from FT-IR study. The saturated solubility was found to increase in the solid dispersed formulation. The swelling index was found within the range of 90±5.43 to 137±6.41. SEM image of swollen tablet confirmed the presence of irregular and porous surface. The cumulative drug release was found to vary within the range of 68.76±3.04 to 95.33±2.34 % after 8 h of dissolution.
 Conclusion: The combination of solid dispersion and application of hydrophilic and hydrophobic polymers in matrix formation can facilitate better dissolution and absorption profile with greater patient compliance.

Formulation Development and in Vitro Characterization of Ternary Hydrotropic Solid Dispersions of Aceclofenac

“…The optimized formulation, U2, possessing ACF: SKM: U in the ratio of 1:5:0.75 demonstrated highest percentage of solubility enhancement of 75% and 36.51% in double-distilled water and phosphate buffer. Urea is reported to promote reduction in crystallinity and to accumulate on hydrophobic surfaces of drug particles, thereby weakening interactions between hydrophobic particles [53][54][55][56]. Urea may have impacted entropy and shifted the dissolution equilibrium of ACF in buffer as well as water by interacting favorably with drug and SKM [57].…”

Development of Extended-Release Formulation of Ibuprofen Using Blends of Calcium Silicate and Polyvinyl Pyrrolidone as Tablet Matrix

“…Despite the many synonyms used to explain delivery strategies that maintain plasma steady-state, ER (extended release) is one of such nomenclatures that accurately describe drug delivery systems that help to achieve these intentions by continuously releasing the therapeutic actives over an extended period of time on single dosing, thereby giving a prolonged therapeutic effect. In the matrix system, an active pharmaceutical ingredient is embedded throughout the polymer matrix of insoluble/hydrophilic substance [3]. Matrix tablets are the type of controlled drug delivery system which releases the drug in continuous manner.…”

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

“…In various drug combinations, biomaterials like fulvic and humic acid, augment solubility, permeability, and dissolution [1]. Greater patient compliance of drugs with ease drug dissolution and absorption profile can facilitate through combinations of potent biomaterial carrier in matrix formation [2]. Range of formulation components and processing methods can contribute significantly in the dissolution rate of pure drugs [3].…”