Formulation and Evaluation of Glutaraldehyde-Crosslinked Chitosan Microparticles for the Delivery of Ibuprofen

Ofokansi, KC; Kenechukwu, Franklin Chimaobi; Isah, AB; Okigbo, EL

doi:10.4314/tjpr.v12i1.4

Cited by 17 publications

(21 citation statements)

References 22 publications

(26 reference statements)

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“…Many researches were devoted to the development and characterization of microparticles for the delivery of ibuprofen [17,[35][36][37][38][39][40]. For instance, Zhang et al [36] concluded that trehalose and glucose are effective cryoprotectants and mannitol and sucrose are not very good cryoprotectants for the ibuprofen-loaded solid lipid microparticles as they crystallize during the freeze-drying process.…”

Section: Discussionmentioning

confidence: 99%

Development and Characterization of Buccal Bilayer Tablets containing Microparticles with Ibuprofen

Conceição

Estanqueiro²,

Amaral³

et al. 2014

AJMSM

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The aim of this study was to develop and characterize buccal bilayer tablets containing ibuprofen microparticles, prepared through emulsion/chilling method, to obtain a sustained release. In this way, three formulations of bilayer tablets containing three bioadhesive polymers, namely Noveon ® AA-1 Polycarbophil USP, Carbopol ® 974 and Carbopol ® 980 were prepared. Weight uniformity, friability, hardness and in vitro drug release studies, by two different methods, were evaluated in the manufactured tablets. The calculation of similarity factor (f 2 ) was also carried out. In addition, three gels (0.5%, w/w) with the same polymers were prepared and textural analysis (firmness and adhesiveness) were assessed in comparison with the bioadhesive layer of tablets. Buccal bilayer tablets with suitable physical properties (weight uniformity, hardness and friability) were produced. In vitro dissolution tests, performed during 8 hours, have demonstrated a sustained release of ibuprofen (maximum drug released: 30.0 -45.1%). According to f 2 , both dissolution methods and the three studied polymers showed similar dissolution profiles (f 2 > 50). Tablets containing Carbopol ® 974 showed higher values of firmness and adhesiveness after 6 h of hydration in phosphate buffer pH 7.4. On the other hand, it was not possible to verify a relationship between the textural parameters of the gels and the bioadhesive layer of tablets containing the same polymers.

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Section: Discussionmentioning

confidence: 99%

Development and Characterization of Buccal Bilayer Tablets containing Microparticles with Ibuprofen

Conceição

Estanqueiro²,

Amaral³

et al. 2014

AJMSM

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“…Then, the mixture was poured into a separatory funnel and allowed to stabilize. After 15 hours, the upper toluene layer saturated with glutaraldehyde was decanted and used as the glutaraldehyde saturated toluene solution [24].…”

Section: Preparation Of Microparticlesmentioning

confidence: 99%

Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg²⁺ for Delayed Drug Release in the Digestive System

Hwang

Shin

2018

International Journal of Polymer Science

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Curcumin-loaded chitosan-pectin microparticles based on polymeric microencapsulation were prepared by two methods to delay the release of curcumin in the digestive system, employing Mg2+ as a pectin-crosslinking agent for the first time. Pectin-coated curcumin-chitosan microparticles (C-g-PMg) and curcumin-loaded chitosan-pectin composite microparticles (C-PMg-g) were formulated, and their release profiles at pH 1.2 and at pH 6.8 were tested. The former (C-g-PMg) showed slower curcumin release profiles than the latter (C-PMg-g) because the C-g-PMg are composed of two layers, a chitosan-glutaraldehyde layer and a pectin-Mg2+ layer, which together hold the curcumin for a longer duration. Of the pectin-coated microparticles, those crosslinked with Mg2+ showed a slower release rate than those crosslinked with Ca2+, but the former showed a faster release rate at pH 6.8 in the presence of pectinase, acting as a promising drug delivery carrier for treating a colonic disease. The pectin layer and the pectin-crosslinking agent play a vital role in prolonging the release of curcumin until pectin is degraded by pectinase.

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“…The complex coacervation technique requires anionic materials that are used for the ionic interaction with protonated chitosan such as vanillin [83], carrageenan [82], alginate [86], gelatine [87,88], gum Arabic [89], etc. Besides, the addition of crosslinking agent improves the mechanical property of chitosan microcapsules such as sodium tripolyphosphate [90][91][92], sodium hydroxide [93,94], genipin [87,88,95] glutaraldehyde [96], tannic acid [97], etc. In the processing of microcapsule with chitosan, a soluble chitosan is prepared in solvent such as acetic acid [89], citric acid [83], etc.…”

Section: Microencapsulation Processesmentioning

confidence: 99%

Chitosan-Based Sustainable Textile Technology: Process, Mechanism, Innovation, and Safety

Roy¹,

Salaün²,

Giraud³

et al. 2017

Biological Activities and Application of Marine Polysaccharides

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This chapter reviews relevant findings regarding the activities and contributions of chitosan in different textile processing following the varieties of process, mechanism, and applications. Chitosan is a better candidate in both aspects of biodegradability and efficiency instead of synthetic polymers. The technical and scientific discussions behind the role of chitosan in all the processes and treatments have been explored in the chapter. Over the last few years, enormous efforts and challenges are being practiced in research and industry to design and development of eco-friendly and sustainable technologies. Therefore, the chapter emphasizes on chitosan-based formulations of fibers, fabrics, coatings, and functional textiles.

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Formulation and Evaluation of Glutaraldehyde-Crosslinked Chitosan Microparticles for the Delivery of Ibuprofen

Abstract: Abstract

Cited by 17 publications

References 22 publications

Development and Characterization of Buccal Bilayer Tablets containing Microparticles with Ibuprofen

Development and Characterization of Buccal Bilayer Tablets containing Microparticles with Ibuprofen

Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg²⁺ for Delayed Drug Release in the Digestive System

Chitosan-Based Sustainable Textile Technology: Process, Mechanism, Innovation, and Safety

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Formulation and Evaluation of Glutaraldehyde-Crosslinked Chitosan Microparticles for the Delivery of Ibuprofen

Abstract: Abstract

Cited by 17 publications

References 22 publications

Development and Characterization of Buccal Bilayer Tablets containing Microparticles with Ibuprofen

Development and Characterization of Buccal Bilayer Tablets containing Microparticles with Ibuprofen

Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System

Chitosan-Based Sustainable Textile Technology: Process, Mechanism, Innovation, and Safety

Contact Info

Product

Resources

About

Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg²⁺ for Delayed Drug Release in the Digestive System