Formulation and Evaluation of Cat Fish Slim Mucin Ointment for Wound Healing

Momoh, Mumuni A.; Sa, Brown; Muogbo, CC

doi:10.4314/tjpr.v12i6.4

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…The protein content of albumin ointment which has the highest value is 0.8% collagen concentration of 1.34%, and the lowest result is 0.4% concentration of 0.96%. The protein content of the albumin ointment produced was lower when compared to the protein content of the ointment in the study of Momoh, et al, (2013), which was 8.5%. The value of protein content in albumin ointment increased along with the increase in collagen concentration.…”

Section: Figure 2 the Results Of Viscositymentioning

confidence: 59%

“…The fat content of albumin ointment which has the highest value is 0.4% collagen concentration of 93.45%, and the lowest result is 0.8% concentration of 88.29%. The fat content of the albumin ointment produced was higher when compared to the fat content of the ointment in the study of Momoh, et al, (2013), amounting to 13.4%. www.ijsrp.org…”

Section: Figure 4 the Results Of Fat Contentmentioning

confidence: 67%

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Effect of Addition of Tiger Grouper (Epinephelus fuscoguttatus) Skin Collagen to Cork Fish (Channa striata) Albumin Ointment on Closure of Cuts

Gunawan¹,

Suprayitno²

2021

IJSRP

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Ointments are semisolid preparations intended for topical application to the skin or mucous membranes. The ointment formulation requires the presence of an ointment base, the ointment base itself is an inactive carrier substance from topical preparations that can be in the form of liquid or solid which brings the active ingredient to contact with the skin. The ointment base used in an ointment formulation must be inert in other words not to damage or reduce the therapeutic effect of the drug it contains. The results of the first study showed that differences in collagen concentrations affected the quality of albumin ointment, namely pH, viscosity, protein content, fat content, and water content. The best albumin ointment was obtained at 0.8% collagen concentration with the following results pH 6.8, viscosity 27980 cP, protein content 1.34%, fat content 88.29%, and water content 2.24%. The results of the amino acid profile test showed that the highest result was Glycine 5618.18 mg/kg and the lowest was L-Tyrosine <66.93 mg/kg. Then continued in the second study, namely amino acid profile testing, zinc levels and experimental mice, the results of observations on day 3, day 5, and day 7 showed that the best concentration of albumin ointment treatment underwent a wound closure process. 75% on the 7th day.

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Section: Figure 2 the Results Of Viscositymentioning

confidence: 59%

Section: Figure 4 the Results Of Fat Contentmentioning

confidence: 67%

Effect of Addition of Tiger Grouper (Epinephelus fuscoguttatus) Skin Collagen to Cork Fish (Channa striata) Albumin Ointment on Closure of Cuts

Gunawan¹,

Suprayitno²

2021

IJSRP

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“…The specific amino acids are glycine, while the fatty acids are arachidonic acid (Wahab et Clarias gariepinus Catfish 5% of catfish mucin ointment showed 100 % wound healing properties on the 12 th day. The ointment showed a significant higher tensile strength and hydroxyproline in the skin, with no record of toxicity Momoh et al, 2013 Channa striatus snakehead murrel…”

Section: Freshwater Fin Fishes With Wound Healing Potentialsmentioning

confidence: 96%

Wound Healing Potentials of some Fin Fishes

2018

International Journal of Research Studies in Biosciences

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Fish is an important source of animal protein. Fish have been widely been exploited by human as food and pharmaceutical sector. Fin fish are distinguished from other fishes (shellfish) by the presence of distinctive anatomical features such as fins and gills. Fishes have been reported to confer several medicinal properties. This study reviewed fin fishes with wound healing potentials. The study showed that fresh water fishes like Channa striatus, Clarias gariepinus, Oncorhynchus mykiss and Cyprinus carpio has mucilaginous compounds that helps as laxative and in healing wounds. Specifically, slime coat of Clariasgariepinus contain mucin that possess antimicrobial properties. Marine fin fish such as Otolithes ruber, Magalaspis cordyla and Oreochromis niloticus possess different forms of collagens that play essential role in wound healing. Therefore, there is the need for research to focus on the isolation and purification of the exact constituents of the fishes that possesses wound healing potentials.

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“…[12] Recently, mucin as a naturally derived macromolecule having such a unique structure and properties has been regarded as a building block of biomaterials, [10] as represented by coating for cell-repellent [13] or cell-selective [14] surfaces, and a component of therapeutic agent for wound healing. [15] Animal mucus forms through the interaction of mucin and nonmucin proteins via dynamic bonds, forming hydrogel having shear moduli in the order of 1-100 Pa. [6,7,16] Similarly, interactions between mucin and various macromolecules including cationic or mucoadhesive proteins, [17,18] polysaccharides, [19][20][21][22] and lectins [23,24] have been extensively studied. Generally, chemical modification is needed for mucins to be used as building blocks of bio-synthetic hybrid materials.…”

mentioning

confidence: 99%

A Bio‐synthetic Hybrid Hydrogel Formed under Physiological Conditions Consisting of Mucin and a Synthetic Polymer Carrying Boronic Acid

Nakahata

Tominaga

Saito

et al. 2022

Macromolecular Bioscience

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Mucin-containing bio-synthetic hybrid hydrogel is successfully formed under physiological conditions upon mixing aqueous solutions of native mucin and synthetic polymers carrying boronic acids. The mechanical properties and stability of the hydrogel in physiological solutions, e.g., cell culture media, are tunable depending on the boronic acid content of polymers. The hydrogel dissolved in the physiological solutions releases native mucin and boronic acid-containing polymer, which can control the adhesion of mammalian cells to the surface. IntroductionBiomacromolecules exert sophisticated functions such as the formation of higher-order structures, biochemical reactions, and intra-and intercellular communications. Alternatively, synthetic polymers have high robustness and functional properties arising from tailor-made molecular design. Hence, bio-synthetic hybrid polymeric materials have attracted much attention due to the sophisticated functions of biopolymers tunable by design freedom of synthetic polymers. [1][2][3][4] Most biopolymers, e.g., proteins, polysaccharides, and nucleic acids, are sensitive to the external environment and easily be denatured under harsh conditions. [5] Thus, bio-synthetic hybrid materials should be used under mild

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Formulation and Evaluation of Cat Fish Slim Mucin Ointment for Wound Healing

Cited by 4 publications

References 14 publications

Effect of Addition of Tiger Grouper (Epinephelus fuscoguttatus) Skin Collagen to Cork Fish (Channa striata) Albumin Ointment on Closure of Cuts

Effect of Addition of Tiger Grouper (Epinephelus fuscoguttatus) Skin Collagen to Cork Fish (Channa striata) Albumin Ointment on Closure of Cuts

Wound Healing Potentials of some Fin Fishes

A Bio‐synthetic Hybrid Hydrogel Formed under Physiological Conditions Consisting of Mucin and a Synthetic Polymer Carrying Boronic Acid

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