Formulation and Evaluation of Carbamazepine Liquisolid Compacts Using Novel Carriers

Dias, Remeth J.; Mali, Kailas K.; Ghorpade, Vishwajeet Sampatrao; Havaldar, Vijay D.; Mohite, Vishal Ramesh

doi:10.5530/ijper.51.2s.52

Cited by 25 publications

(16 citation statements)

References 25 publications

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“…9 and 10, there is a reduction in intensity of the characteristic absorption bands of drug in liquisolid formulations which might be attributed to the hydrogen bonding interaction of the amin group of lacidipine with the hydroxyl group of the PEG 200. This resulted in drug dissolution enhancement as shown by dissolution data [34]. …”

Section: Fourier-transform Infrared Spectroscopy (Ftir)mentioning

confidence: 89%

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Preparation and in Vitro Evaluation of Lacidipine Oral Liquid Solid Tablet as an Approach of Solubility and Dissolution Rate Enhancement

Rajab

2018

Int J App Pharm

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Objective: The aim of the present study was to prepare a new liquid-solid tablet to enhance the dissolution and bioavailability of a poor water soluble calcium channel blocker lacidipine.Methods: Firstly, solubility study of lacidipine in different media of water-miscible non-volatile solvents as tween 20, tween 80, propylene glycol, liquid paraffin, PEG200, PEG400, and PEG600 was investigated to select the most suitable solvent. A mathematical model was applied to calculate the appropriate amount of carrier and coating material.Four liquid-solid tablets of 6 mg lacidipine were prepared by dissolving the drug in the previously chosen water miscible non-volatile solvents, then a binary mixture of the carrier (Avicel PH 102) and coating material (Aerosil 200) at a ratio of 45:1 was used in all preparation since it gave the optimal flow property. Croscarmellose and magnesium stearate were incorporated in all prepared formulas as super disintegrant and lubricant respectively. On the other hand, directly compressed lacidipine tablet of the same previous composition without the addition of any non-volatile solvent was prepared for comparism study. Both characterizations of powder mixture and post-compression tablet evaluations were done. Differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy (FTIR) were investigated for the pure drug, physical mixture, and selected liquid-solid tablet to exclude any drug-excipients interaction. Results:The obtained results indicated that PEG 200 was the most suitable solvent with lacidipine solubility of 2.81 mg/ml. Flowability of all the prepared formulas was found to be within the specification limits. The liquid-solid tablet formula with PEG 200 at 10% w/w lacidipine was the most suitable one in the term of disintegration time (21±0.2 second), 100% of drug release within 10 min, and with accepted other tablet properties.DSC thermograms for both physical mixture of selected liquisolid system and its tablets illustrated the formation of lacidipine amorphous solid solution. The absence of chemical interaction between drug and other formula components was confirmed by remaining all characteristic peaks of lacidipine in all investigated FTIR spectra. Conclusion:Liquid-solid tablet was considered as a promising system to enhance solubility and dissolution rate of poor-water soluble lacidipine.

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Section: Fourier-transform Infrared Spectroscopy (Ftir)mentioning

confidence: 89%

“…From the result, it is concluded that concentration of drug in liquid medication is an important factor in drug release [33]. A decrease in concentration of drug in PEG 200 increases the dispersion of drug at molecular level which may further enhance the dissolution rate of the drug [34].…”

Section: In Vitro Drug Dissolution Studiesmentioning

confidence: 99%

Preparation and in Vitro Evaluation of Lacidipine Oral Liquid Solid Tablet as an Approach of Solubility and Dissolution Rate Enhancement

Rajab

2018

Int J App Pharm

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“…The drug concentration in each solution was analyzed by UV spectrophotometer at 210 nm. 15 Preparation of Liquisolid Compacts: Ramipril liquisolid systems were prepared and compressed into tablets of 20 mg strength each, using a single punching machine with the aim of the desired hardness of 3-6 kg/cm 2 . All liquisolid formulations contained microcrystalline cellulose as the carrier powder and silica as the coating material at a fixed powder excipient ratio (R) of 20.…”

Section: Methodsmentioning

confidence: 99%

Untitled

2019

IJPSR

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The aim of the present investigation was to enhance the dissolution of poorly water-soluble drug Ramipril (BCS-II) drug through Liquisolid compact. The liquisolid compacts were prepared with a varied quantity of liquid and powder ingredients using microcrystalline cellulose as a carrier, Aerosil 200 as a coating material, polyethylene glycol 400, propylene glycol and tween-80 as liquid vehicles, HPMC as additives to increase loading capacity. The required quantities of ingredients for the compressible admixture were calculated using various mathematical models. The in-vitro release characteristics of different dissolution conditions were performed. All formulated systems were assessed for precompression parameters like flow properties, FTIR analysis, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and post-compression parameters like content uniformity, weight variation, hardness, friability, disintegration test, wetting time and in-vitro dissolution studies. As liquisolid compacts demonstrated significantly higher drug release rates, thereby indicating a promising strategy in improving the dissolution of poorly water-soluble drugs and formulating immediate release solid dosage forms.

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“…Thus, there is no undesired interaction between the drug and excipients. It can be noticed a reduction in intensity of the characteristic absorption bands of the drug in liquisolid formulations which might be attributed to the hydrogen bonding interaction of the amino and carboxyl group of furosemide with the hydroxyl group of the liquid vehicles PEG 400 [45].…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Formulation and Evaluation of Furosemide Liquisolid Compact

Jassim

2017

Int J App Pharm

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Objective: The purpose of this study was to enhance the dissolution pattern of the practically water-insoluble diuretic drug, furosemide through its formulation into liquisolid tablets.Methods: A mathematical model was used to formulate four liquisolid powder systems using polyethylene glycol 400 as a non-volatile water miscible liquid vehicle. The liquid loading factors of the vehicle were used to calculate the optimum quantities of carrier (Avicel PH 102) and coating materials (Aerosil 200) needed to prepare acceptably flowing and compactible powder mixtures and (R) ratio used was 25. The liquisolid tablets were evaluated for weight variation, percent friability, hardness, content uniformity, disintegration time and in vitro drug release profile. Drug and the prepared systems were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder xray diffraction (PXRD) studies. Results:The enhanced dissolution rate due to the increased wetting properties and the large available surface areas for dissolution were obtained in case of the liquisolid tablets. The selected optimal formulation (F2) of 50% drug concentration released 90% of its content during the first 10 min compared to 65% of DCT. FTIR studies revealed that there was no interaction between drug and polymers. DSC and PXRD indicated conversion of crystalline to amorphous form of furosemide. Conclusion:The dissolution rate of furosemide can be enhanced to a great extent by liquisolid technique.

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Formulation and Evaluation of Carbamazepine Liquisolid Compacts Using Novel Carriers

Cited by 25 publications

References 25 publications

Preparation and in Vitro Evaluation of Lacidipine Oral Liquid Solid Tablet as an Approach of Solubility and Dissolution Rate Enhancement

Preparation and in Vitro Evaluation of Lacidipine Oral Liquid Solid Tablet as an Approach of Solubility and Dissolution Rate Enhancement

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Formulation and Evaluation of Furosemide Liquisolid Compact

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