Formulation and evaluation of a pulsatile drug delivery system using time- and pH-dependant polymers

Kadam, Vinayak D.; Gattani, Surendra G.

doi:10.3109/10837450902980254

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…There was practically no release if RS100 was used. This phenomenon was explained by a reduced ability of the copolymer mixture to swell [30].…”

Section: Film Coatings Using Solutions Of Copolymers In Non-aqueous Smentioning

confidence: 95%

“…It was shown [30] that pulsed delivery of tabletted theophylline into the colon could be achieved by using a monolayer coating that varied in thickness (5 -10%) and contained a mixture of Eudragit ® grades S100/RS100 in 2:3, 1:1, and 4:1 ratios and S100/RS100 in a 3:1 ratio that were prepared from a CH 2 Cl 2 :i-PrOH (3:7) solvent mixture. As it turned out, increasing the S100 content slowed significantly the drug release.…”

Section: Film Coatings Using Solutions Of Copolymers In Non-aqueous Smentioning

confidence: 99%

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Interpolymer combinations of chemically complementary grades of Eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (review)

Mustafin

2011

Pharm Chem J

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Principles of the combination of chemically complementary grades of Eudragit ® copolymers in peroral, matrix, and reservoir types of solid dosage forms with modified release [tablets, microspheres, (micro)pellets] and their manufacturing technology (including film coatings) are considered. Modified drug release is achieved due to the interaction between reactive groups of copolymer pairs, which controls the drug release process both inside matrices and within multilayers or combined coatings. Analysis of these processes has key significance for developing (meth)acrylate polycomplexes, which could be synthesized in both aqueous and organic media, as new classes of drug carriers for constructing modern peroral drug delivery systems.

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“…There was practically no release if RS100 was used. This phenomenon was explained by a reduced ability of the copolymer mixture to swell [30].…”

Section: Film Coatings Using Solutions Of Copolymers In Non-aqueous Smentioning

confidence: 95%

Section: Film Coatings Using Solutions Of Copolymers In Non-aqueous Smentioning

confidence: 99%

Interpolymer combinations of chemically complementary grades of Eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (review)

Mustafin

2011

Pharm Chem J

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“…Programmable pulsatile, colon-specific release was achieved from a capsule device over a 2-24 h period, consistent with the demands of chronotherapeutic drug delivery. Kadam and Gattani (2009) formulated and evaluated fast release enteric-coated tablets for pulsatile drug release to the colon. The novelty of this work was the combination of pH-and time-dependant enteric polymers as a single coating agent.…”

Section: Chemical Stimuli Induced Systemmentioning

confidence: 99%

Chronopharmaceutics: As a clinically relevant drug delivery system

Gandhi¹,

Mundada²,

Gandhi³

2010

Drug Delivery

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“…The problem with this approach is that the intestinal pH may vary because it is affected by diet, disease, presence of fatty acids and other fermentation products. Moreover, there is a considerable difference in inter-and intraindividual gastrointestinal tract pH, and this causes a major problem in reproducible drug delivery to the large intestine 10 . The most commonly used pH dependent polymers are derivatives of acrylic acid and cellulose 11 .…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of a Colon Drug Delivery System Containing Diflunisal

Din

Maghraby

Donia

et al. 2014

Bulletin of Pharmaceutical Sciences. Assiut

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EgyptOral drug delivery is the most desirable and preferred method of administering therapeutic agents for providing both systemic and local effects in various parts of the gastrointestinal tract. Recently, greater emphasis has been placed on controlling the site and/or rate of drug release from oral formulations to improve treatment efficacy and patient compliance. Many novel oral drug therapeutic systems have been invented like fast release, targeted release and colon specific drug delivery systems etc.. During the last decade there has been an interest in developing site specific formulations for targeting to the colon. The delivery of drugs to the colon has a number of therapeutic implications in the field of drug delivery. Localized delivery of the drugs in the colon is possible only when the drug is protected from the hostile environment of upper GIT. The various approaches that can be exploited to target the release of drug to colon include prodrugs, coating with pH sensitive polymers, coating with biodegradable, timed release systems, osmotic and bioadhesive polymers.In the present study, solid dispersions of pH-dependent, time dependent and combined pHand time-dependent systems were formulated using Eudragit RS100, Eudragit S100, Eudragit L100 and ethylcellulose, with different drug-to-polymer ratios. They were evaluated for their in-vitro release characteristics in an attempt to develop a colon-specific delivery system containing Diflunisal. Release studies of Diflunisal and Diflunisal solid dispersion systems with different polymers were employed using Release apparatus, USP (paddle type) (copley, England) showed that, the combination of pH-and time-dependent systems provided better results than the pH-dependent or the time dependent system alone. Using Eudragit S100 and Eudragit RS100 with Diflunisalin a ratio 2:3:1, respectively for preparing a solid dispersion used for developing a colon-specific delivery system of Diflunisal was the most successful formula. This formula released 0.22±0.03% of the drug included in it in the stomach pH and 26.29±0.91% of the drug in the intestine pH and 77.59±1.79% of the drug in the colon pH.

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Formulation and evaluation of a pulsatile drug delivery system using time- and pH-dependant polymers

Cited by 9 publications

References 14 publications

Interpolymer combinations of chemically complementary grades of Eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (review)

Interpolymer combinations of chemically complementary grades of Eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (review)

Chronopharmaceutics: As a clinically relevant drug delivery system

Formulation and Evaluation of a Colon Drug Delivery System Containing Diflunisal

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