Formulation and Development of Sustained Release Matrix Tablets of Lornoxicam

Abstract

The aim of the present study was to prepare sustained release matrix tablets of lornoxicam to make drug in sustained form so as to prolong its elimination time for the effective treatment of rheumatoid arthritis, and also in the management of ankylosing spondylitis, acute sciatica and low back pain. The present investigation demonstrates that, use of hydrophilic and hydrophobic polymers could be successfully employed for formulating sustained release matrix tablets of Lornoxicam. Optimized formulation containing HPMC K100M and Ethyl cellulose at optimum ratio had successfully sustained the drug release for 24 h. Matrix tablets of optimized batch had in vitro drug release. It was observed that the optimized matrix tablets of optimized batch shows better flow property by studying various pre-compression parameters. Thus, sustained release matrix tablets of Lornoxicam using biocompatible polymers were successfully formulated, evaluated and found to be suitable candidates in extending the release of the drug from the matrix tablets.

Development, characterization and in VIVO evaluation of diffusion controlled transdermal matrix patches of a model anti-Inflammatory drug

“…A blank was prepared in the same manner using drug free patches to neglect the absorption of formulation components. After filtration, the drug content was determined spectrophotometrically at 378 nm [1,12] .…”

“…Lornoxicam is an extremely potent NSAID that is commonly used for effective control of arthritic pain and inflammation, also in relieving the pre/post operative pain associated with different surgeries [1] . The drug requires frequent oral administration due to its rapid elimination and thus modulates well known gastrointestinal side effects of NSAIDs ranging from mild dyspepsia, heartburn to ulcer and bleeding [2] .…”

Development of lornoxicam multiparticulate sustained release drug delivery system using copal gum-pectin and optimization by applying central composite design

“…A series sieve of no. 8,10,16,22,36,44, and 44 were arranged in order of decreasing aperture size. An accurately weighed amount of pellets from each batch was placed on the uppermost sieve.…”

“…Sustained release film coated and matrix tablets are available in market, but there are possibilities of dose dumping which leads to poor bioavailability due to small intestine absorption site [7][8]. Therefore considering various advantages of multiparticulate drug delivery system over tablets helps to better drug distribution, less irritation, more stability and unique release pattern for increase bioavailability.…”

Formulation And Evaluation Of Sustain Release Matrix Based Tablet Of Ketorolac Tromethamine Using Tamarind Gum And Tapioca Starch Natural Polymers As Release Modifiers

“…The preparation of sustained release matrix tablets involves the direct compression of blend powder mixture of drug, retardant material and other additives to formulate a tablet in which the drug is dispersed in a matrix of the tablet. These systems continuously releases the drug by dissolution-controlled and diffusion-controlled mechanisms [9].…”