Formulation and Characterization of Hydrophilic Ointment Bases with Carvacrol and Magnolol for Periodontal Application

Cicalău, Georgiana Ioana Potra; Miere, Florina; Mandal, Amit; Ganea, Mariana; Scrobotă, Ioana; Ciavoi, Gabriela; Jurcă, Claudia

doi:10.51847/a7vnt1hx00

Cited by 5 publications

(3 citation statements)

References 37 publications

(38 reference statements)

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“…Magnolol hydrogels are also prepared in the same way. The preparation formulas are shown in Table 1, as we previously mentioned in another article [35]. Table 1.…”

Section: Preparation Of Hydrogelsmentioning

confidence: 99%

“…Each receptor chamber has a diffusion surface of 1.767 cm 2 and a volume Table 1. The quantities of substances used for the preparation of hydrogels and their role [35].…”

Section: Release Of Carvacrol and Magnolol From Hydrogelsmentioning

confidence: 99%

“…After diabetes and periodontitis were installed, 400 µg/mL of carvacrol and 25 µg/mL of magnolol incorporated in bioadhesive hydrogels using carbopol 1% [35] were topically applied in the gingival sulcus and the adjacent oral mucosa. A syringe with a blunt tip was used at the level of the dental package of the molar with ligature, then dispersed evenly with a spatula on the vestibular and lingual surfaces of the tooth [53,54].…”

Section: Experimental Designmentioning

confidence: 99%

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Assessing the Antioxidant Benefits of Topical Carvacrol and Magnolol Periodontal Hydrogel Therapy in Periodontitis Associated with Diabetes in Wistar Rats

Potra Cicalău,

Ciavoi,

Scrobotă

et al. 2023

Dentistry Journal

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It is well recognized that oxidative stress contributes to chronic stress-induced cytotoxicity, which is a major factor in the progression of many diseases, including periodontitis and diabetes. Formulas based on natural extracts with antioxidant properties are alternative treatment perspectives in the management of such diseases. The aim of our study was to assess how carvacrol and magnolol influence periodontitis associated with diabetes in Wistar rats. Ninety Wistar rats were distributed in nine groups: I—control group; II—diabetes group (D); III—periodontitis group (P); IV—periodontitis and diabetes group (PD); V—periodontitis and diabetes with vehicle alone (PDV); VI—periodontitis and diabetes treated with carvacrol (PDC); VII—periodontitis and diabetes treated with magnolol (PDM); VIII—periodontitis and diabetes treated with carvacrol and magnolol (PDCM); IX—healthy group with vehicle alone (CV). Blood malondialdehyde (MDA) levels and catalase activity levels (CAT) were measured as indicators of oxidative stress and antioxidant capacity, respectively. Where diabetes and periodontitis were induced, MDA was augmented and CAT was depleted significantly. Whether given alone (PDM) or in combination with carvacrol (PDCM), magnolol significantly decreased MDA. Between the PDM group and the PDCM group, there were no notable differences. In Wistar rats with periodontitis related to diabetes, topical use of hydrogels containing magnolol, either alone or in combination with carvacrol, may reduce oxidative stress.

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“…Magnolol hydrogels are also prepared in the same way. The preparation formulas are shown in Table 1, as we previously mentioned in another article [35]. Table 1.…”

Section: Preparation Of Hydrogelsmentioning

confidence: 99%

“…Each receptor chamber has a diffusion surface of 1.767 cm 2 and a volume Table 1. The quantities of substances used for the preparation of hydrogels and their role [35].…”

Section: Release Of Carvacrol and Magnolol From Hydrogelsmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

See 1 more Smart Citation

Assessing the Antioxidant Benefits of Topical Carvacrol and Magnolol Periodontal Hydrogel Therapy in Periodontitis Associated with Diabetes in Wistar Rats

Potra Cicalău,

Ciavoi,

Scrobotă

et al. 2023

Dentistry Journal

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Study of Periodontal Bacteria in Diabetic Wistar Rats: Assessing the Anti-Inflammatory Effects of Carvacrol and Magnolol Hydrogels

Potra Cicalău,

Marcu,

Ghitea

et al. 2024

Biomedicines

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Periodontal disease and diabetes often co-occur; both are characterized by chronic inflammation. This study aimed to investigate the anti-inflammatory effects of carvacrol and magnolol when incorporated into a periodontal hydrogel and topically applied to Wistar rats with diabetes-associated periodontal disease. Forty male albino Wistar rats were divided into four groups: PD (induced diabetes and periodontitis), PDC (induced diabetes and periodontitis treated with carvacrol), PDM (induced diabetes and periodontitis treated with magnolol), and PDCM (induced diabetes and periodontitis treated with both carvacrol and magnolol). Post treatment, gingival tissue samples were collected to measure levels of the pro-inflammatory cytokines IL-6 and TNF-α. The PDCM group exhibited significantly lower levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) compared to the PD group. The combined application of a periodontal hydrogel containing carvacrol and magnolol may significantly reduce gingival inflammation in rats with diabetes-associated periodontal disease.

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Novel Topical Formulations Based on O. Basilicum and T. Pratense: Antioxidant, Antimicrobial, and Anti-Inflammatory Effect

Antonescu¹,

Antonescu²,

Miere³

et al. 2022

Pharmacophore

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This study aimed to highlight the importance of phytochemical-based formulations in the treatment of wounds with different etiologies, avoiding the possible side effects generated by conventional treatments. We present the preparation method of novel topical formulations (cream, ointment, and hydrogel) based on mixed extracts of Ocimum basilicum and Tifolium pratense along with evidence of their antimicrobial and antioxidant effect in vitro. The anti-inflammatory and wound healing properties of the new formulations were evaluated against different chronic inflammatory processes by presenting three clinical cases of chronic skin diseases. The clinical cases presented in our study revealed good outcomes of the cream formulation in the case of dyshidrotic eczema, ointment formulation in the case of hypertrophic scar, and hydrogel formulation in the case of psoriasis lesions. The best effect was noticed after 6 days of topical application of hydrogel on psoriatic plaques, resulting in a significant reduction of erythematous plaques.

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Formulation and Characterization of Hydrophilic Ointment Bases with Carvacrol and Magnolol for Periodontal Application

Cited by 5 publications

References 37 publications

Assessing the Antioxidant Benefits of Topical Carvacrol and Magnolol Periodontal Hydrogel Therapy in Periodontitis Associated with Diabetes in Wistar Rats

Assessing the Antioxidant Benefits of Topical Carvacrol and Magnolol Periodontal Hydrogel Therapy in Periodontitis Associated with Diabetes in Wistar Rats

Study of Periodontal Bacteria in Diabetic Wistar Rats: Assessing the Anti-Inflammatory Effects of Carvacrol and Magnolol Hydrogels

Novel Topical Formulations Based on O. Basilicum and T. Pratense: Antioxidant, Antimicrobial, and Anti-Inflammatory Effect

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