Novel Topical Formulations Based on O. Basilicum and T. Pratense: Antioxidant, Antimicrobial, and Anti-Inflammatory Effect

Abstract

This study aimed to highlight the importance of phytochemical-based formulations in the treatment of wounds with different etiologies, avoiding the possible side effects generated by conventional treatments. We present the preparation method of novel topical formulations (cream, ointment, and hydrogel) based on mixed extracts of Ocimum basilicum and Tifolium pratense along with evidence of their antimicrobial and antioxidant effect in vitro. The anti-inflammatory and wound healing properties of the new formulations were evaluated against different chronic inflammatory processes by presenting three clinical cases of chronic skin diseases. The clinical cases presented in our study revealed good outcomes of the cream formulation in the case of dyshidrotic eczema, ointment formulation in the case of hypertrophic scar, and hydrogel formulation in the case of psoriasis lesions. The best effect was noticed after 6 days of topical application of hydrogel on psoriatic plaques, resulting in a significant reduction of erythematous plaques.

Characterization in Terms of Phytochemical Content and Medicinal Potential of the Stellaria media Plant Extract

“…Briefly, 60 grams of the dry plant for each extraction method were crushed and 70% ethanol was added to them in a ratio of 1:20 (w/v) respectively distilled water in the same volume to obtain the aqueous extract. The mixture was kept in the dark under continuous stirring for 24 hours, then filtered [16,17].…”