Formulation and characterization of curcumin loaded polymeric micelles produced via continuous processing

Gupta, Anand; Costa, António Pedro; Xu, Xiaoming; Su-Lin, Lee; Cruz, Celia N.; Bao, Quanying; Burgess, Diane J.

doi:10.1016/j.ijpharm.2020.119340

Cited by 42 publications

(32 citation statements)

References 29 publications

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“…This intensity begins to increase linearly above its CMC, as the number of micelles in solution linearly increases with concentration, scattering light monotonically. Therefore, the intersection of the straight lines that best matched the data obtained corresponds to the CMC of the polymeric dispersion [49,50].…”

Section: Dynamic Light Scattering (Dls)mentioning

confidence: 77%

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Interaction between mucoadhesive cellulose derivatives and Pluronic F127: Investigation on the micelle structure and mucoadhesive performance

Silva

Santos

Silva

et al. 2021

Materials Science and Engineering: C

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Section: Dynamic Light Scattering (Dls)mentioning

confidence: 77%

“…Micelle formation and critical micelle concentration (CMC) were studied using a Zetasizer Nano ZS (Malvern, UK) [49,50]. Samples were diluted in purified water.…”

Section: Dynamic Light Scattering (Dls)mentioning

confidence: 99%

Interaction between mucoadhesive cellulose derivatives and Pluronic F127: Investigation on the micelle structure and mucoadhesive performance

Silva

Santos

Silva

et al. 2021

Materials Science and Engineering: C

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“…A high-performance formulation of curcumin phospholipid complex, which can improve the flow, solubility, and oral bioavailability of curcumin, was developed by Wang et al [ 108 ]. Polymer micelles made using block copolymer methoxy-poly(ethylene glycol) (mPEG)-poly(caprolactone) (PCL) enable delayed release of curcumin [ 109 ].…”

Section: Formulationsmentioning

confidence: 99%

Curcumin: Biological Activities and Modern Pharmaceutical Forms

et al. 2022

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Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action. Numerous studies have identified and characterised the pharmacokinetic, pharmacodynamic, and clinical properties of curcumin. Curcumin has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, and it is used as a wound-healing agent. However, poor curcumin absorption in the small intestine, fast metabolism, and fast systemic elimination cause poor bioavailability of curcumin in human beings. In order to overcome these problems, a number of curcumin formulations have been developed. The aim of this paper is to provide an overview of recent research in biological and pharmaceutical aspects of curcumin, methods of sample preparation for its isolation (Soxhlet extraction, ultrasound extraction, pressurised fluid extraction, microwave extraction, enzyme-assisted aided extraction), analytical methods (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) for identification and quantification of curcumin in different matrices, and different techniques for developing formulations. The optimal sample preparation and use of an appropriate analytical method will significantly improve the evaluation of formulations and the biological activity of curcumin.

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“…[110][111][112][113] Efficient synthesis of welldefined block copolymers is a critical application of anionic polymerization in a microreactor. [114][115][116][117][118] Tanaka and co-workers synthesized PS-b-PMMA (M n = 92.4 kg mol −1 , Đ M = 1.03) by using an anionic coupling method and microreactor technology (Fig. 5).…”

Section: Synthesis Of Block Copolymersmentioning

confidence: 99%