Formulated antidiabetic preparation Syndrex® has a strong antioxidant activity

Dixit, Priyanjali; Devasagayam, T.P.A.; Ghaskadbi, Surendra

doi:10.1016/j.ejphar.2007.11.052

Cited by 16 publications

(9 citation statements)

References 38 publications

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“…122 This has been further confirmed in our laboratory by checking the ability of Syndrex, a formulated anti-diabetic drug with strong antioxidant capacity to improve the functionality and viability of islet cells in vitro by conferring them better protection against oxidative damage. 123 In addition to oral administration of antioxidants, overexpression of genes responsible for antioxidant enzymes in islets also exhibit better protection against damage caused by free radicals and this strategy could possibly serve as a valuable pharmacological approach towards treating diabetes. Adenoviral based overexpression of glutathione peroxidase in human islets increased GPx activity and protected islets against ribose induced oxidative stress 124,125 and also enhanced the resistance of rat β-cell line to both ROS and RNS cytotoxicity.…”

Section: Poor Defense Mechanism Of Islets: Boon or Bane?mentioning

confidence: 99%

Islets and their antioxidant defense

Acharya¹,

Ghaskadbi²

2010

Islets

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Pancreatic β-cells secrete insulin in response to changes in extracellular glucose concentration. Persistent hyperglycemia during diabetes exerts toxic effects on islets by creating redox imbalance arising from overproduction of reactive oxygen species (ROS). ROS accumulation disturbs the integrity and physiological function of cellular biomolecules impairing viability and functionality of cells. Susceptibility of an organ to oxidative stress (OS) is determined by its defense mechanism and ability to repair DNA damage caused by ROS. Weak defense status of islets along with its inefficiency to repair oxidative DNA damage as compared to other tissues renders it extraordinarily sensitive to OS. Realizing the vulnerability of islet cells to oxidative damage, several efforts to boost their defense mechanism in the form of oral administration of antioxidants and overexpression of genes responsible for antioxidant enzymes have proven successful. Recently accountability for this low antioxidant defense of islets have been given by correlating it with its metabolic evolution.

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Section: Poor Defense Mechanism Of Islets: Boon or Bane?mentioning

confidence: 99%

Islets and their antioxidant defense

Acharya¹,

Ghaskadbi²

2010

Islets

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“…Most of the currently used chemotherapy drugs for cancers are known to develop resistance, exhibit non-selective toxicity against normal cells and restrict by dose-limiting side effects (Rao et al, 2007;Carr et al, 2008). In addition, the commercially available drugs for diabetes (such as acarbose) are restricted by demonstrated to slow the disease progression by retarding glucoseauto-oxidative radicals (Dixit et al, 2008;Kim et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth.

Ooi

Muhammad

Tan

et al. 2011

Journal of Ethnopharmacology

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“…The plates were incubated at 37° for 20 min and the absorbance of each solution was measured at 490 nm using ELISA reader against the corresponding test and standard and the remaining DPPH was calculated. IC 50 is the concentration of the sample required to scavenge 50% of DPPH free radical[10]. Percentage of inhibition is calculated by subtracting the absorbance of the sample from the absorbance of the control divided by absorbance of the control.…”

mentioning

confidence: 99%

Antioxidant and antimicrobial activity ofalpinia officinarum

Srividya¹,

Dhanabal²,

Misra³

et al. 2010

Indian J Pharm Sci

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Alpinia officinarum is a rhizome belonging to the family zingeberaeceae. Hydro alcoholic extract by hot and cold maceration and methanol extract by percolation process Qualitative phytochemical analysis of extract of Alpinia officinarum rhizome showed a majority of the compound including tannins, alkaloids, flavonoids and saponins. Hydroalcoholic extract prepared by hot maceration process was found to contain more phenol and flavonol and it was measured as 50.1 mg/g and 54.02 mg/g, respectively. All the three extracts showed moderate to potent antimicrobial activity against the Bacillus cereus, Staphylococcus aureas, Pseudomonas auroginosa, Escherichia coli. None of the extracts showed antifungal activity against Aspergillus niger and Candida albicans. All the three extracts showed a concentration dependent radical scavenging activity by inhibiting diphenylpicrylhydrazyl free radical at the same time hydroalcoholic extract prepared by hot maceration process showed better reducing and total antioxidant activity.

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Formulated antidiabetic preparation Syndrex® has a strong antioxidant activity

Cited by 16 publications

References 38 publications

Islets and their antioxidant defense

Islets and their antioxidant defense

Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth.

Antioxidant and antimicrobial activity ofalpinia officinarum

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