FORMULASI ORALLY DISINTEGRATING TABLET (ODT) EKSTRAK ETANOL DAUN TAHONGAI (Kleinhovia hospita L.) DENGAN VARIASI KONSENTRASI EXPLOTAB®

Abstract

Tahongai leaves (Kleinhovia hospita L.) is a medicinal plant that has antioxidant activity which is almost equivalent to vitamin C. The development of the dosage form to improve the utilization of these plants. Therefore Tahongai leaves made in the form Orally Disintegrating Tablets (ODT), which has several advantages such as more practical use because it can be consumed without the use of water and can be used by people who are hard to swallow capsules or tablets as well as having good taste in the mouth. This study was carried out experimentally using four formulas with various concentrations Explotab® ie; formula 1 (2%); formula 2 (4%); Formula 3 (6%) and the formula 4 (8%). The evaluation of ODT are uniformity of weight, hardness, friability and disintegration time.The results showed that the concentration Explotab® influence on the physical properties of ODT ie hardness, friability and disintegration time. Explotab® concentration of 4% is the best concentration that meets the requirements of the physical properties ODT Tahongai leaf extract.
 
 Keywords: Formulation, Orally Disintegrating Tablets (ODT), Explotab, Tahongai
 (Kleinhovia hospita L.)

Orally Disintegrating Tablet Formulation of Avicennia Fruit Ethanol Extract (Avicennia marina)

“…The flowability test result showed that in Formula II when Crosspovidone was higher, the flow time was also long. In the research of Sa'adah and Fudholi (2011) [12], the higher the specific gravity of a powder, the faster its flowability. It is known that Starch 1500 has a specific gravity of 0.88 g/mL and Crosspovidone has a specific gravity of 0.273 g/ml [13].…”

“…Wicking is the ability of the tablet to absorb water when placed into a liquid so that it will make the particle bonds loosen and causing it to break [19]. Ethanol Extracts (Kleinhovia hospita L.) with Explotab as superdisintegrant [12].…”